Home Search for your polling place in Virginia, and find out what's on the ballot for the next upcoming election.

Polls are open until 7pm for the VA referendum today 4/21. Find your polling place here, and dont forget to bring your ID! #vote www.elections.virginia.gov/casting-a-ba...

A nice depiction of the problem.

Anthropic secretly installs spyware when you install Claude Desktop — That Privacy Guy! Anthropic's Claude Desktop silently installs a Native Messaging bridge into seven Chromium browsers, including browsers Anthropic's own documentation says it does not support, and browsers the user ha...

#oopsie
Anthropic secretly installs spyware when you install Claude Desktop
www.thatprivacyguy.com/blog/anthrop...

schematic artwork

Schematic of our model of abscission failures in neuroepithelium. 6/6.

Abnormal cells are extra large, outlined in red, with multiple green cilia and multiple nuclei in white

When #abscission fails AND #apoptosis fails, we see weird monster cells with XL apical membranes, extra #cilia, and extra nuclei!...So, completion of cytokinetic abscission maintains epithelial structure, and p53 is the "guardian of epithelial structure" when abscission fails. 5/6

double knockout epithelium shows extra large apical membranes outlined in red

What happens if we block apoptosis in this epithelium having #abscission failures? Does that rescue the enlarged apical membranes back to normal size? No! Now, we see extra-large apical membranes! Some double-XL! (Normally, #p53 mediates apoptosis of cells that fail abscission, but we KO'd p53.) 4/6

Control epithelium has red honeycomb pattern. Knockout epithelium has irregular red honeycomb pattern with some cells too large.

If some cells fail to complete #abscission, the apical membranes are enlarged. Why? Is it because they fill in the empty space leftover when neighbor cells die? No. We did the experiment. 3/6

a single neural stem cell is labeled with red lipophilic dye showing it's spindly shape

How does a tall skinny cell in an epithelium divide??
What happens if it fails to complete cytokinesis? 2/6

Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia | Molecular Biology of the Cell Cytokinetic abscission genes are linked to cancers and developmental disorders, but the consequences of disrupted abscission in vivo remain under-explored. Previously we showed that in the forebrain o...

Our latest #abscission paper is online at MBoC www.molbiolcell.org/doi/10.1091/... . We looked at what happens when there are stochastic abscission failures in a polarized epithelium in vivo. 1/6

Reposting today since Bluesky was weird yesterday. Also for #fluorescencefriday image of green cilia on apical membranes of neural stem cells. See our new preprint for details! www.biorxiv.org/content/10.6...

😂

From MBoC…

Now accepting submissions for the Cell Biology of the Nervous System special issue. Share your research on nervous system cell biology with the community: https://www.molbiolcell.org/nervous-system/

Our preprint about Togaram1 mouse knockout brain phenotypes is on bioRxiv! This is a model of Joubert Syndrome ciliopathy caused by loss of Togaram1 (aka Crescerin1 aka FAM179B). Primary #cilia defects in neural stem cells. Neurogenesis, mitotis, apoptosis, morphogenesis phenotypes! #cellbio

Dear SDB Members, I am writing to clarify how to fully comply with the 2024 NIH Public Access Policy without paying the current $3,910 Article Processing Fee for Open Access for your paper accepted in Developmental Biology. Attached is a diagram showing the process. Once you receive the letter of acceptance for your paper in Developmental Biology, upload the accepted and unformatted version of your manuscript to the NIH Manuscript Submission system, NIHMS (nihms.nih.gov). Select “0 months” for the embargo. Once approved, you will receive a PCMID number for your manuscript. Your manuscript will then be publicly accessible, satisfying the NIH Public Access Policy requirement. If you choose the “Open Access” option, you will pay the $3,910 Article Processing Fee. If you choose the “Subscription” option, you do not pay any fee. Developmental Biology has traditionally not charged authors for any fees as it was subsidized by institutional subscriptions. Royalties from Developmental Biology's institutional subscriptions also support SDB’s programs. SDB encourages you to ask your library to subscribe to Developmental Biology. Save your funds and support the SDB, while also fully complying with the NIH Public Access Policy! Yours truly, Richard Behringer, PhD

Another Society journal doing the right thing! @socdevbio.bsky.social confirms that upon acceptance in @devbiol.bsky.social authors can upload the accepted and unformatted version of your manuscript to the NIH Manuscript Submission system, satisfying NIH and making it available to all

You are finishing your PhD and looking to continue in science?

The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....

Thanks for reposting!

We have a postdoc position available. Please forward to anyone who may be interested.

Photo of Gail R. Martin

SDB is sad to announce the passing of Gail R. Martin (1944-2026) after a short illness in San Francisco. Martin served as SDB President in 2007 and was the recipient the Conklin Medal in 2002 and the @FASEBorg Excellence in Science Award in 2011. bit.ly/4aIfu5d

Amen. So many non-specific antibodies, so much wasted money and time.

Worth reading for possible explanations and their suggested experiments in Discussion. Note that peer review time was defined as the time from submission to acceptance, so includes time spent on revisions. Would have liked to see that separated out.

Sorry for your loss, Mark! Gail was a giant in the field and such a good person.

Sad to hear about Gail's passing! She was a dev bio pioneer and role model.

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species A fundamental role for division orientation in progenitor output driving cortical and retinal growth is revealed.

Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...

Looks like a must read! So I'm wondering why GPSM2 single ko (randomized division angles) has no change in brain size, no SBH, (as per Konno '08 etc), but your double ko ("reversed orientation divisions") has bigger brain with SBH? And how does it compare to Insc ko (Postiglione '11)?

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function - Nature Communications Here they combine in vivo imaging with proteomics to characterize a protein complex comprised of Ccdc78 and Ccdc33 that acts at the extreme distal tip of 9 + 2 motile cilia to control tip architecture...

Cilia alert! Stoked to have the new paper from Juyeon Hong about a new domain at the extreme distal tip of motile cilia! (The EDT, y'all!) It's out now @natcomms.nature.com.
Check it out!
#cilia

www.nature.com/articles/s41...

The Murphy Lab did our annual retreat this week. This year's theme was using AI (what it's good and bad for). I wanted to be open-minded to make sure we are not missing something we should be using it for, so we did a few exercises to test, and had presentations.

Thanks for this Coleen! Your conclusions align with my (limited) experiences so far, but I keep hearing some scientists saying it's useful for searches, so I wonder if it depends on the AI, or maybe they're better at prompts than me... or maybe you have to be expert on a topic to see the mistakes.

AI-Generated Scientific Papers: Crisis? What Crisis? Picture a man in a deckchair, umbrella overhead, relaxing with a drink in hand—while surrounded by industrial wasteland and decay. This was the iconic 1975 album cover for Supertramp's Crisis? What Cr...

Important editorial in #eNeuro about paper mills using AI to generate fake or plagiarized papers. Anyone else worried about having your preprints or unpublished results taken, AI-rearranged, and scooping you? @sfnjournals.bsky.social www.eneuro.org/content/13/1...

Great session and wonderful questions, thanks for organizing it Pleasantine! @cilialab.bsky.social‬
#UKCilia2026

Excited to be sharing our work on Togaram1 mouse knockout and brain development in this e-Symposium Tuesday, January 13, 2026! 10:00 AM EST in the US = 15:00 GMT #cilia #centrosomes #devbio 🐭🧠🧪

Just over a week to our FIRST event for 2️⃣0️⃣2️⃣6️⃣- 13/01/2026 15:00-17:30 GMT. What better way to fire up those neural circuits than dipping into the latest breaking #Cilia and #Centrosome science 🧪? Free and open to everyone- /1