Katerina Naydenova Katerina Naydenova

Next up: Katerina Naydenova, Group Leader at the Max Planck Institute of Molecular Physiology, will present "Molecular mechanisms of #ubiquitin ligases with activity towards non-protein substrates".

📅 22 April 2026
⏰ 12:30
📍 S05 V01 E69

➡️ www.mpi-dortmund.mpg.de/forschungsgr...

MARK YOUR CALENDARS | On May 5th, 3pm, in Hatch Auditorium & hosted by @paulkennyphd.bsky.social, Dr. Ming-Ming Zhou & Dr. Mone Zaidi, Yale University's Dr @craigmcrews.bsky.social will give a Special Seminar concerning one of the most exciting areas in drug discovery research today. Please join us!

What a probe! Congratulations @cepourroy.bsky.social!
We're happy to share that we re working hard on making CenSpark probes available to the centriole aficionados in the coming weeks!

Locating the cell division trigger Every time a cell divides, it reaches a deciding moment, a tipping point when it chooses to move forward, change state, begin something new and form two new cells.

"Science moves forward by questioning what is thought obvious and closely following the evidence, even when it leads to surprising results."

Read about the collaboration between Nitin Kapadia and Paul Nurse and their efforts to figure out where mitosis begins:
www.crick.ac.uk/news/2026-03...

"Our findings identify ECM composition and mechanics as a primary mechanism governing mammalian regeneration. By demonstrating that the ECM acts as a mechanochemical signalling hub, we show that “retuning” the physical environment from a stiff, collagenous state to a soft, HA-rich state can.."

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

🥁 New insights alert! Today, we take you into the fascinating world of RING-type E3 ubiquitin ligases through this article from our #Highlights2025 collection.
📕 RING dimerisation drives higher-order organisation of SINA/SIAH E3 ubiquitin ligases
➡️ buff.ly/rIErxm1
#ubiquitin #E3ligase #RING #SIAH1

MitoAtlas: a Domain-Resolved Spatial Map of the Human Mitochondrial Proteome www.biorxiv.org/cont...

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#proteomics #prot-preprint

Roland Dunbrack: Structural bioinformatics and protein structure prediction at multiple scales YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)

Here is the talk I gave @asbmb.bsky.social for the DeLano Award in Computational Biosciences in March 2026.

www.youtube.com/watch?v=g0Gv...

Project Hail Mary is very good if you ignore the centrifuge debacle. Worthy successor to The Martian.

Excited to see our work out in Science today! Using machine learning to identify prokaryotic immune systems www.science.org/doi/10.1126/...

Navigating condensate micropolarity to enhance small-molecule drug targeting - Nature Chemical Biology Using computational and experimental methods, Ouyang and Chen et al. reveal a drug design principle that the hydrophobic properties of small-molecule drugs significantly influence their ability to eng...

www.nature.com/articles/s41...

www.biorxiv.org/content/10.6...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

A little late to Bluesky but my postdoc work w/ @jbuenrostro.bsky.social now out in @nature.com
"Epigenetic memory of colitis promotes tumour growth"
www.nature.com/articles/s41...

We wanted to understand how transient inflammation can create an increase in cancer risk, even after full recovery 🧵

Why do intrinsically disordered proteins appear larger than they are in SDS-PAGE? We investigate how sequence properties affect SDS-PAGE mobility using synthetic IDRs.

Conclusion: We need to consider both SDS binding and the compaction of protein-SDS complexes.

www.biorxiv.org/content/10.6...

CBP-IDRs regulate acetylation and gene expression Gelder et al. demonstrate that intrinsically disordered regions (IDRs) with divergent sequence properties maintain a functional balance between positive and negative regulation of CBP condensates. This intramolecular mechanism tunes CBP’s sensitivity to lysine acetylation; its disruption fundamentally alters chromatin binding, histone acetylation, and gene expression.

CBP-IDRs regulate acetylation and gene expression

Atlas of predicted protein complex structures across kingdoms

www.nature.com/articles/s41...

www.biopredictnavigator.cn

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social

A 🧵

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications AI-powered pipeline converts antibodies into functional intrabodies, enabling live-cell imaging of peptides and histone marks.

And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.

NAC promotes co-translational protein folding at the ribosomal tunnel exit Santos et al. reveal NAC’s co-translational interactome, showing compartment-specific nascent chain interactions in human cells. NAC engages emerging chains at the ribosomal tunnel exit via a ribosome...

www.cell.com/molecular-ce...

Happy to this published. Congrats to the authors. It affirms many things we also saw in our Ribo-seq data irrespective of model (human cell lines vs C. elegans) and sample prep. Very cool, to finally see data on how NAC acts a cotranslational chaperone.

Mike Bishop at his 90th birthday party surrounded by former trainees. Feb 23rd, 2026, Larkspur, CA

Devastated to learn of the passing of the great cancer pioneer J. Michael Bishop.

Mentor and friend, it was only a few weeks ago we celebrated his 90th birthday.

He taught us that the seeds of cancer lie within us and spent his career combating cancer. 🧪

@ucsfcancer.bsky.social

No stasis in proteostasis - Nature Structural & Molecular Biology In this issue of Nature Structural & Molecular Biology, we focus on all things protein homeostasis, highlighting a variety of processes, from protein quality control in translation to autophagy.

The @natsmb.nature.com March issue is out! Though always interested in proteostasis, in 2026 we have published and will continue to do so relevant content. Our editorial www.nature.com/articles/s41... recaps why the processes and mechanisms of proteostasis continue to interest us.

🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

FEBS Press Native holdup allows the quantitative determination of affinities between full-length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which ca...

Excited to share our new paper on DNA-native holdup!
An updated method to measure DNA–protein binding affinities at high throughput - even for full-length transcription factors. @teamgogl.bsky.social

#TranscriptionFactors #GATA1 #ProteinDNA #Biophysics #Genomics #MolecularBiology #OpenScience

RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1 Abstract. Mitotic fidelity requires proper chromosome alignment at the spindle equator, a process known as chromosome congression, mediated by well-establi

Delighted to share our latest work in @narjournal.bsky.social on the importance of (lnc)RNA–protein interactions in cell division, and how we identified RSRC2 as a new RBP involved in splicing and centrosome-associated RNA localisation
academic.oup.com/nar/article/...

Ribosome-associated quality control and related mechanisms Nature Structural & Molecular Biology, Published online: 17 March 2026; doi:10.1038/s41594-026-01771-1Here the author highlights and summarizes the latest advances in ribosome-associated quality control and related mechanisms.

ICYMI: New online: Ribosome-associated quality control and related mechanisms

Single-molecule peptide sequencing through reverse translation of peptides into DNA www.nature.com/artic...

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#proteomics #prot-paper

I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

Great opportunity to join @hellerschmiedlab.bsky.social @unidue.bsky.social @imprs-lm.bsky.social