PROTAC degraders recruiting MDM2
www.scienceopen.com/hosted-docum...
#PROTAC #MDM2 #E3Ligase #TargetedDegradation #DrugDesign

This review highlights the role of SUMO #E3Ligase #RANBP2 in cell cycle control and #tumorigenesis, identifying this nuclear pore complex protein as a promising yet underexplored target for #SolidTumors needing clinical validation.

#OpenAccess: doi.org/10.1016/j.ge...

🥁 New insights alert! Today, we take you into the fascinating world of RING-type E3 ubiquitin ligases through this article from our #Highlights2025 collection.
📕 RING dimerisation drives higher-order organisation of SINA/SIAH E3 ubiquitin ligases
➡️ buff.ly/rIErxm1
#ubiquitin #E3ligase #RING #SIAH1

#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity

#OpenAccess in #STTT: doi.org/10.1038/s413...

📝 Available online - the Spotlight "New insights in regulation of RAS isoforms revealed by protein structures" from Taiki Abe and Alice Berger.

#RASGTPase #LZTR1 #E3ligase #ubiquitin #degradation

Read it here: authors.elsevier.com/a/1mJnK3S6Gf...

The #E3ligase #UBR5 suppresses #ColorectalCancer by driving #ubiquitin‑mediated degradation of #Snail, limiting #EpithelialMesenchymalTransition & invasion; low UBR5 predicts poor prognosis, highlighting the UBR5–Snail axis as a #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Speed of life: tuning the ticktock of the segmentation clock A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

OUTLOOK: Speed of life: tuning the ticktock of the segmentation clock
By Sally Lowell
➡️ https://tinyurl.com/gd353096

Read the paper:
➡️ https://tinyurl.com/gd352909

#Notch #E3ligase #segmentationclock #somitogenesis #somitoid

The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during Pseudomonas syringae pv. tomato DC3000 infection Abstract. Plant immunity involves complex regulatory mechanisms that mediate the activation of defense responses against pathogens. Protein degradation via

Study reveals SlATL2 E3 ligase dampens tomato immunity to Pst DC3000 by degrading SlCSN5a. Insights for crop resistance! #PlantImmunity #E3Ligase @OxfordJournals
Details: doi.org/10.1093/hr/u...

The E3 ubiquitin ligase SlATL2 suppresses tomato immunity by promoting SlCSN5a degradation during Pseudomonas syringae pv. tomato DC3000 infection Abstract. Plant immunity involves complex regulatory mechanisms that mediate the activation of defense responses against pathogens. Protein degradation via

SlATL2 E3 ligase in tomatoes suppresses immunity to Pst DC3000 via SlCSN5a degradation. Insights for crop resistance! #PlantImmunity #E3Ligase #CropProtection @OxfordJournals
Details: doi.org/10.1093/hr/u...