#ACSL4 is a target for β-hydroxybutyrate-induced increase in fatty acid content and lipid droplet accumulation in #bovine mammary epithelial cells
❇️https://doi.org/10.1016/j.jia.2024.12.004
#AnimalScience @keaipublishing.bsky.social

🔥Hot Off the Press | Can #VitaminC slow biological aging in primates?
A new study in Cell Metabolism defines a conserved “ferro-aging” axis in primates, where iron accumulation drives chronic lipid peroxidation and systemic decline. #ACSL4, acting as a key executor, promoting cellular senescence.

#ExtracellularVesicles from #Steatotic livers deliver #ACSL4 to hepatocytes, driving #ferroptosis-triggered mitochondrial #apoptosis that worsens #IschemiaReperfusionInjury, while Ferrostatin‑1 blocks this pathway to reduce #GraftInjury.

#OpenAccess: doi.org/10.1016/j.ge...

This recent study reviews the role of #ACSL4 in #Ferroptosis, #OxidativeStress, & #Neuroinflammation, highlighting novel compounds that target ACSL4 and paving the way for #Clinical innovation in #AlzheimersDisease intervention. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...