Image shows some of the researchers from the international research team involved in this development: From left to right: Dr Samrat Basak mastering the new generation of microfluidics system; Kim-Chi Vu in process of preparation of specialized muscle cells of the heart; Dr Roman Tsukanov in the optical/microfluidics lab. They are all shown in action in the laboratories engaged in different aspects of developing and using the system. Photo: Samrat Basak, Kim-Chi Vu, Roman Tsukanov

A photo showing the system itself – with many buttons, wires, tubes and components. This shows the compressed-air-driven microfluidics system tailored for multiplexed super-resolution microscope developed by the research team to provide accessible, cost-efficient, high-quality imaging of cells, including fragile biological samples. Image thanks to Roman Tsukanov

How are components in cells organized?

It's a huge challenge for science to visualize this! So researchers developed a microfluidics system to make high-resolution microscopy easier, more reproducible and accessible: www.uni-goettingen.de/en/3240.html...

#ACSNano: pubs.acs.org/doi/10.1021/...

Making Room at the Nanoscale: A Tangible Perspective on Surface Crowding and Molecular Design Designing functional nanoparticles requires more than controlling size and shape; it demands spatial awareness at the molecular level. While surface functionalization is often described in terms of li...

I’m happy to share our new ACS Nano paper, Making Room at the Nanoscale.👩🏻‍🔬 It reflects both scientific curiosity and the importance of making the invisible visible.🔬

pubs.acs.org/doi/10.1021/...

#ACSNano #Nanoscience #Nanotechnology #Nanomaterials #MaterialsScience #Chemistry @pubs.acs.org

How do MXenes align under flow?

In our recent paper in ACS Nano (@pubs.acs.org) in-situ SAXS reveals size-dependent shear alignment in Ti3C2Tx - key info towards boosting fiber properties!

doi.org/10.1021/acsn...

#MXene #2DMaterials #SAXS #ACSNano

Thermogravimetric Analysis and Mass Spectrometry of 2D Polyaramid Nanoplatelets Two-dimensional (2D) polyaramids (2DPAs) have recently emerged as a class of organic 2D nanomaterials exhibiting high mechanical strength and gas barrier properties. However, their characterization remains challenging due to their hybrid molecular structure, combining features of conventional 2D inorganic materials with those of organic polymers, which results in limited solvent dispersibility. Herein, we elucidate how thermal degradation, monitored by thermogravimetric analysis coupled with mass spectroscopy (TGA-MS), can provide chemical insights into the end group and discoidal molecular structure of 2DPAs. We find that distinct thermogravimetric loss regimes correlate with the ratio of aromatic-to-end group proton peak integrations from 1H NMR, referred to as the r value. This informs the end group chemical composition, which can be linked to a consistent set of mechanistic steps for thermal degradation. For instance, isopropyl-ester-terminated 2DPA-1 decomposes first through a six-centered intermediate formed from the intramolecular methyl hydrogen interaction with the carbonyl, yielding 1-propene after cleavage of the C–O bond, consistent with mass spectrometry. Kinetic parameters, including activation energies, are determined using the Coats–Redfern method from TGA data, with values spanning 11.8 to 63.6 kJ/mol. The analysis is extended to ethyl-ester- and carboxyl-terminated 2DPA-1 for comparison. This study establishes the utility of TGA and TGA-MS as versatile characterization tools for 2D polyaramids with distinct terminal groups, allowing measurement and therefore control of nanoplatelet functionalization and molecular weight.

Thermogravimetric Analysis and Mass Spectrometry of 2D Polyaramid Nanoplatelets #ACSNano pubs.acs.org/doi/10.1021/...

🚨My new cover for #ACSNano!

I designed the artwork to capture the moment when multiple colorful light beams strike a single-layer material. The glowing waves rising from the surface represent the newly generated twisted light 💡

🔗 doi.org/10.1021/acsn...

Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure Gestational exposure to micro- and/or nanoparticles (M/NPs) may be closely associated with adverse maternal and offspring outcomes involving multiple organ dysfunctions. Organ functional change is achieved through metabolic adaptation in response to changes in the external environment; yet, intricacies of these organ dysfunctions and underlying metabolic changes remain poorly understood, particularly at spatial suborgan level. Using a pregnant mouse model exposed to polystyrene (PS)-M/NPs (sizes: 100 nm, 5 μm, 10 mg/L in drinking water) from gestation day 1 to 18, we construct a comprehensive multisub-organ lipid metabolic landscape. This analysis integrates MALDI-mass spectrometry imaging with histological assessment to monitor changes in maternal suborgans-placenta-fetus unit. Our findings reveal distinct metabolic responses between maternal and fetal organs to gestational PS-M/NPs exposure. We identify potential targeted suborgans and spatial biomarkers associated with PS-M/NPs exposure according to histological damage and metabolic remodeling, including placental junctional and labyrinth zone (e.g., phosphatidylserine, phosphatidylethanolamine [PE]), renal cortex of maternal kidney (e.g., ceramide [Cer], PE, sphingomyelin [SM], phosphatidylglycerol [PG], phosphatidylserine), ventricular muscular layer and interventricular septum of maternal heart (e.g., PE, lysophosphatidylethanolamine [LPE], lysophosphatidic acid [LPA]), fetal brain and spinal cord (e.g., Cer), and fetal liver (e.g., Cer). Furthermore, phosphatidylserine synthesis and glycolipid metabolism pathways are found to be exclusively enriched following PS-NP and PS-MP exposure in the multiorgan network, respectively. We propose an M/NPs scale-exposed suborgan effect framework, which provides a molecular foundation and potential spatial biomarkers for elucidating intersub-organ interactions in response to M/NPs exposure and their role in mediating pregnancy state.

Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure #ACSNano #MassSpec pubs.acs.org/doi/10.1021/...

Orientational Order of Phenyl Rotors on Triangular Platforms on Ag and Au(111) We investigated trioxatriangulenium functionalized with phenyl (phenyl-TOTA) on the (111) surfaces of Ag and Au using low-temperature scanning tunneling microscopy (STM) and density functional theory ...

200 years ago M. Faraday discovered benzene, but we are still learning about it. Just published in #ACSNano @pubs.acs.org, we show that direct interaction over 1 nm orders a network of benzene rotors mounted on triangular platforms. @uni-kiel.de @cfmdonostia.bsky.social pubs.acs.org/doi/full/10....

Unraveling Ligand-Driven Isomerism in Redox-Active Mixed-Ligand Polyoxometalates Using Ion Mobility Spectrometry Redox-active metal-oxide clusters that combine atomic precision with tunable solubility and electronic structure are emerging as functional components for energy storage, catalysis, and quantum materials. Polyoxovanadate (POV)-alkoxides, in particular, offer a modular platform where ligand shell composition can be tailored without disrupting the core structure. However, structural characterization of mixed-ligand POV-alkoxides is hindered by the presence of compositional and isomeric heterogeneity. Here, we report the structural investigation of mixed-ligand Lindqvist-type POV-alkoxides using ion mobility–mass spectrometry (IM-MS) coupled with density functional theory (DFT) and collision cross section (CCS) simulations. We examine two series of clusters, [V6O7(OR1)12–x(OR2)x] (x = 0–8), with ligands of varying steric bulk: methoxy/ethoxy (MeO/EtO) and ethoxy/ethoxyethyl (EtO/EOE). While the MeO/EtO series shows a linear increase in CCS with ligand substitution, the EtO/EOE series exhibits a curved trend and broadened CCS distributions, indicating the formation of multiple low-energy isomers. DFT results reveal that this behavior arises from the preferential extension and clustering of bulky EOE ligands on one side of the core. Comparison of experimental and simulated CCS distributions further indicates that high-CCS isomers are not formed under solvothermal conditions. Instead, the as-synthesized solution contains isomers in which the bulky EOE ligands cluster on one side of the hexavanadate core. These findings demonstrate the power of gas-phase structural analysis to resolve subtle isomeric preferences in complex molecular assemblies and offer a framework for understanding ligand-directed assembly in redox-active metal-oxide clusters.

Unraveling Ligand-Driven Isomerism in Redox-Active Mixed-Ligand Polyoxometalates Using Ion Mobility Spectrometry #ACSNano pubs.acs.org/doi/10.1021/...

Danske forskere har vist, hvordan alfa-synuclein-oligomerer danner porer i hjerneceller. Mette G. Malle udviklede platformen bag fundet. Nyt skridt i forståelsen af #Parkinsons.

Læs: lundbeckfonden.com/uddelinger-priser/forskn...
#ACSnano

Nanoparticles Induce Protein Corona Conformational Change to Reshape Intracellular Interactome for Microglial Polarization Nanoparticles bind to proteins in cells selectively and form a protein corona around them. However, the mechanisms of protein conformational changes underlying the interactions between nanoparticles a...

Nanoparticles Induce Protein Corona Conformational Change to Reshape Intracellular Interactome for Microglial Polarization #ACSNano #MassSpec pubs.acs.org/doi/10.1021/...

🌎 New #scientificpublication at #ACSNano
📍Technology Roadmap of Micro/Nanorobots
👩‍🔬🧑‍🔬 X. Ju, et al.
👉 https://f.mtr.cool/sswtfgmbij

Advances in Antimicrobial Applications of Ag, Cu, and AgCu Nanoparticle-Doped Polymeric Composite Materials: A Comprehensive Review The growing challenge of antimicrobial resistance (AMR) has driven the search for alternative strategies to conventional antibiotics, with metallic nanoparticles (NPs), particularly silver (Ag), copper (Cu), and their bimetallic hybrids (AgCu), emerging as promising candidates. These nanoparticles exhibit strong, multifaceted antimicrobial activity and, when integrated into polymeric matrices, form composite materials that offer enhanced stability, controlled release, and broad applicability across healthcare, food safety, and industrial sectors. This review highlights the major synthetic routes for the production of Ag, Cu, and AgCu nanoparticles and discusses their integration into polymeric systems. Furthermore, the antimicrobial mechanisms of these nanomaterials are explored. Finally, the review emphasizes the potential of these nanocomposites to serve as next-generation antimicrobial surfaces, wound dressings, and functional materials, while addressing key synthesis challenges and proposing future research directions to optimize their performance and expand their applications.

Curious about the potential of Silver–Copper Nanoparticles in antimicrobial applications? 🦠⚡
Check out our latest paper in ACS Nano 👉 doi.org/10.1021/acsn...
Happy reading! 📖
#Nanoscience #Nanomaterials #ACSNano #Antimicrobials

Chiroptical Control of Gold Nanoparticle Growth through Combination of a Multimodal Chirality Inducer and Surfactant Counterion Chiral plasmonic nanomaterials display strong interactions with circularly polarized light, offering significant potential in chirality sensing, enantioselective catalysis, and biomedical applications. While recent advances in seeded-growth synthesis have yielded complex chiral gold nanostructures through chemically induced or micelle-directed growth mechanisms, detailed intercorrelated mechanisms remain elusive. In this context, we have systematically investigated the versatility of the chiral inducer 2-amino-N-decyl-3-mercaptopropanamide (LipoCYS), which incorporates both an amino acid moiety and an aliphatic chain designed to bridge both established mechanisms. By employing cubic and octahedral achiral gold seeds and varying the surfactant halides, along with the concentration of LipoCYS, we generated a wide range of chiral morphologies, from twisted helicoids to intricate wrinkled spheres and intermediate structures. Advanced electron microscopy, including electron tomography, enabled comprehensive three-dimensional characterization and revealed distinct chiral morphological transitions and their correlations with chiroptical properties. Excellent agreement was found with the simulation results, thereby validating the representativeness of the microscopic analysis. Our findings expand the synthetic toolbox available for the precise control of nanoparticle chirality, providing deeper insights into the mechanisms of chiral growth and enhancing their potential for tailored applications.

Check out our latest #ACSnano publication, a work based on the collaboration between @lizmarzan-lab.bsky.social and @ematsarabals.bsky.social, partners in #CHIRAL-PRO, together with #SeoulNationalUniversity and @cicaudc.bsky.social. Read the paper here! pubs.acs.org/doi/10.1021/...
@erc.europa.eu

👉 Check out our perspective published in #ACSNano @acs.org

📑Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

V Sousa @brunomladeira.bsky.social E Garanger S. Lecommandoux EW Meijer P Dankers JF Mano

🔗 pubs.acs.org/doi/10.1021/...

Chromato-Kinetic Fingerprinting Enables Multiomic Digital Counting of Single Disease Biomarker Molecules Early and personalized intervention in complex diseases requires robust molecular diagnostics, yet the simultaneous detection of diverse biomarkers─microRNAs (miRNAs), mutant DNAs, and proteins─remain...

Precision medicine diagnostics reimagined—Bio-SCOPE merges chromatic & kinetic molecular fingerprinting for ultra-sensitive multiomic profiling: Detect femtomolar miRNA, mutant DNA & protein. #ACSNano

Diffusion of DNA on Atomically Flat 2D Material Surfaces Accurate localization and delivery of biomolecules are pivotal for building tools to understand biology. The interactions of biomolecules with atomically flat 2D surfaces offer a means to realize both...

🧬 Fantastic work by Dong Hoon Shin (former postdoc in our lab) on 'Diffusion of DNA on Atomically Flat 2D Material Surfaces' out now in #ACSNano!

pubs.acs.org/doi/10.1021/...

Designing Ultraporous Mesostructured Silica Nanoparticles for the Remediation of Per- and Polyfluoroalkyl Substances Concerns about per- and polyfluoroalkyl substances (PFAS) have been raised globally as they are bioaccumulative, highly persistent, and invoke a range of health risks. Although phytoremediation is a s...

Designing Ultraporous Mesostructured Silica Nanoparticles for the Remediation of Per- and Polyfluoroalkyl Substances #ACSNano #MassSpec pubs.acs.org/doi/10.1021/...

#acsnano | Giuseppe Battaglia Our latest work, published in #ACSNano and showcased in the issue cover, shows how to grow 2 nm gold nanoparticles inside polymersome membranes — not as decoration, but as engines. These tiny plasmoni...

Very happy to share our latest #ACSNano work!
www.linkedin.com/feed/update/...

Gold Cluster-Based Profiling of Early Stage Acute Kidney Injury through Second Near-Infrared Fluorescence Imaging and Mass Spectrometry Imaging Acute kidney injury (AKI) poses a major challenge due to the rapid deterioration of renal function, for which the optimal intervention timing has already passed until clinical diagnostics sense abnorm...

Gold Cluster-Based Profiling of Early Stage Acute Kidney Injury through Second Near-Infrared Fluorescence Imaging and Mass Spectrometry Imaging #ACSNano pubs.acs.org/doi/10.1021/...

🌟My new cover for #ACSNano!

This paper highlights how #interdisciplinary collaboration is essential in complex fields like #nanomedicine and #biomedical_engineering. A great example is the development of the COVID-19 vaccine🦠, where global, transparent teamwork accelerated life-saving treatments.

Fine-tune energy flow with atom swaps! A new #ACSNano publication from Prof. Greg Engel & Prof. Giulia Galli labs reveal new possibilities in cesium bismuth halide quantum dots for next-gen devices. #quantumdots #materials

pubs.acs.org/doi/10.1021/...

Energy-Confinement 3D Flower-Shaped Cages for AI-Driven Decoding of Metabolic Fingerprints in Cardiovascular Disease Diagnosis Rapid and accurate detection plays a critical role in improving the survival and prognosis of patients with cardiovascular disease, but traditional detection methods are far from ideal for those with ...

Energy-Confinement 3D Flower-Shaped Cages for AI-Driven Decoding of Metabolic Fingerprints in Cardiovascular Disease Diagnosis #ACSNano #MassSpec pubs.acs.org/doi/10.1021/...

In Situ Bioconjugation of Synthetic Peptides onto Universal Chimeric Antigen Receptor T Cells for Targeted Cancer Immunotherapies The recent development of modular universal chimeric antigen receptor (CAR) T-cell platforms that use bifunctional adaptor intermediates to redirect engineered T-cell effector function has greatly expanded the capabilities of adoptive T-cell therapy, enabling safer and more comprehensive cancer treatment. However, universal CAR receptor systems rely on unstable transient recognition of tag-coupled intermediates for T-cell activation, and the array of targeting intermediates has been limited to antibodies and small molecules. Addressing these shortcomings, we engineered universal CAR T-cell receptors that can be covalently modified with synthetic biomaterials in vivo by accelerated SpyCatcher003-SpyTag003 chemistry for cancer-cell targeting. SpyCatcher003-modified CARs, nicknamed DB5 CARs, displayed fast, low-nanomolar reaction kinetics with a synthetic αvβ6-binding peptide that incorporates a SpyTag003 peptide via branched peptide synthesis to comprise a bifunctional intermediate. Prearming DB5 CAR T cells or prelabeling target cells with the bifunctional peptide produced selective CD4+ and CD8+ CAR T-cell responses against αvβ6+ cancer cells in vitro. Furthermore, the synthetic targeting intermediate showed robust DB5 CAR T-cell arming in vivo and selectively reduced αvβ6+ tumor progression in a dual flank xenograft model. We demonstrate the versatility and therapeutic potential of “Cyborg” CAR T-cell therapies that utilize synthetic biomaterials to direct CAR T-cell activity via highly selective bioconjugation that occurs in vivo.

It's officially "Live"....Cyborg CAR T Cells. Our paper was published today in #ACSNano (stay tuned for actual "in press" date)... when one ventures on a “side-project” to target cell therapies to the #CNS. …LOTS of persistence by Ian Cardle, PhD. (some cussing too!)😂

urldefense.com/v3/__https:/...

Nomadic Nanomedicines: Medicines Enabled by the Paracrine Transfer Effect In nanomedicine, the cellular export of nanomaterials has been less explored than uptake. Traditionally viewed in a negative light, recent findings highlight the potential of nanomedicine export to en...

New in #ACSNano: Faculty member Chad Mirkin collaborates with Natalie Artzi of Harvard Medicine to uncover the Paracrine Transfer Effect in #nanomedicine!
Discover how export pathways & smart design can reshape treatments: pubs.acs.org/doi/abs/10.1...

Resistive-Pulse Sensing Coupled with Fluorescence Lifetime Imaging Microscopy for Differentiation of Individual Liposomes Characterization of individual biological nanoparticles can be significantly improved by coupling complementary analytical methods. Here, we combine resistive-pulse sensing (RPS) with fluorescence lif...

Biological nanoparticles, anyone?

RPS-FLIM combines the benefits of resistive-pulse sensing (RPS) and fluorescence lifetime imaging microscopy (FLIM) to differentiate dye-labeled biological nanoparticles by size, charge, and membrane composition. #ACSNano

doi.org/10.1021/acsnano.4c10813

Improve #LipidNanoPariticle delivery to #Glioblastoma

👉Local injection
👉Convection-enhanced delivery via⏫colloidal stability outer surface mod with poly-L-glutamate/hyaluronate
👉⏫Tumor cell targeting vs unmod liposome
👉In vivo retention t1/2 12~13 d

#ACSNano 2023
pubs.acs.org/doi/10.1021/...

Applications of Nanotechnology for Spatial Omics: Biological Structures and Functions at Nanoscale Resolution Spatial omics methods are extensions of traditional histological methods that can illuminate important biomedical mechanisms of physiology and disease by examining the distribution of biomolecules, in...

Applications of Nanotechnology for Spatial Omics: Biological Structures and Functions at Nanoscale Resolution #ACSNano #MassSpec pubs.acs.org/doi/10.1021/...

Reflecting on the ACS Nano Summit 2024 hosted by
CityU Hong Kong
💡 Grateful for the wealth of knowledge shared, connections made, and the celebration of scientific excellence 🙏

Click here to find out more: 👉 t.ly/d-19F 👈

#ACSNano #CityUHK #ScienceSummit

Targeting #EndMT (Barrier/Mechanics/Inflammation) in vitro using N-cadherin antibody-conjugated natural melanin nanoparticle

HUVEC
HDMVEC
HCAEC

Ignore the title type; Clean in vitro data; wait for in vivo data

#AcsNano 2024
pubs.acs.org/doi/10.1021/...