Reviewing how the complex interplay of critical cellular players drives extracellular matrix accumulation in #OrganFibrosis, guiding emerging #Antifibrotic strategies by leveraging #Multiomics and precision therapeutics.

#OpenAccess: doi.org/10.1038/s413...

This review shows how #microRNAs regulate #AdiposeTissueFibrosis via key pathways, while miRNA-engineered stem-cell #secretomes enable targeted delivery and stronger #antifibrotic effects, offering strategies for metabolic fibrosis treatment.

#OpenAccess: doi.org/10.1016/j.ge...

#FollistatinLike1 shapes the fibrotic immune #microenvironment, enabling #MSC‑driven #macrophage recruitment and remodeling to boost #antifibrotic efficacy in #LiverCirrhosis, positioning FSTL1 as a #biomarker of #StemCellTherapy response.

#CoverPage #STTT: doi.org/10.1038/s413...

Graphical abstract of the original paper, source: orig. paper

🧪 Scientists have developed a powerful new #Galectin-3 inhibitor — featuring a 6-carboxyindol-4-yl amide core. It binds Gal-3 effectively, shows excellent #selectivity and stability, and reduces fibrotic signaling in hepatic cells. A strong lead for #antifibrotic #therapy!

🔗 buff.ly/5tm7bj6
(MK)

Editorial for the Fibrosis and antifibrotic drugs article collection now available!
onlinelibrary.wiley.com/doi/10.1111/...

More information about the article collection here: onlinelibrary.wiley.com/page/journal...
#SFPT #Wiley #pharmacology #fundamental #clinical #fibrosis #drug #antifibrotic

#Rheumatoid #Arthritis-Associated Interstitial Pneumonia Refractory to Initial Therapy: Successful Control Through Combined #Anti-Inflammatory, #Antifibrotic and #JAK-STAT-Targeted Treatment
onlinelibrary.wiley.com/doi/10.1002/...

MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223 Announcing a new article publication for BIO Integration journal. Liver fibrosis is caused by excessive extracellular matrix accumulation, which in turn is driven by activation of hepatic stellate cel...

This commentary summarizes the mechanistic functions of microRNA-223 (#miR223) in #HepaticStellateCell activation and #fibrosis, discusses its #therapeuticpotential and highlights it as a complex but intriguing target for #antifibrotic treatment.

#OpenAccess: bio-integration.org/micrornas-li...

Remarkable: a treatment for progressive pulm. fibrosis #fibroticILD. #Nerandomilast a molecule with #antifibrotic and anti-inflammatory effect, slows down FVC deterioration. Additionally, a weak signal of benefit on secondary end points, seen beyond week 52 of therapy.
www.nejm.org/doi/full/10....

Nerandomilast slows FVC deterioration in IPF patients without/with background #antifibrotic therapy.
- No additional protection from IPF exacerbation
- Pirfenidone decreases plasma levels of Nerandomilast by 50% as opposed to nintedanib.
#pulmonaryfibrosis #ATS2025
www.nejm.org/doi/full/10....

Should read this study carefully!
#Nerandomilast from @boehringerglobal.bsky.social an orally administered preferential inhibitor of phosphodiesterase 4B in #pulmonaryfibrosis. Results of a phase 3 study with background #antifibrotic therapy. #ATS2025
www.nejm.org/doi/full/10....

looking forward to the #antifibrotic SIG program. The next frontier in ending liver disease. #liver15 #liverleader https://shar.es/1u0LUt