Astrocytic H3 receptors regulate anxiety through GABA signaling Li et al. identify a hypothalamic histaminergic circuit projecting to hippocampal vCA1 that encodes anxiogenic contexts. This pathway engages astrocytic H3 receptors, triggering Ca2+ signals and subse...

#Astrocytic H3 receptors regulate #anxiety through #GABA signaling: Neuron www.cell.com/neuron/fullt...

'AstroWars: the return of the #astrocytic metabotropic glutamate receptor 5' 🔎

A review by José Duarte Dias @icvs-uminho.bsky.social, João Filipe Viana, Luís Samuel Alves, Alexandra Veiga, Bruna Matos, João Luís Machado & João Filipe Oliveira ✍️

📜 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Astrocytic WNT5B–NFATc2 signaling drives MMP14-mediated #ECM degradation and MSN damage in #HuntingtonsDisease, while #genistein suppresses this pathway to rescue #neuropathology, motor deficits, and lifespan. @bumedicine.bsky.social

#OpenAccess in #STTT: doi.org/10.1038/s413...

Scientists reveal that #astrocytic MAOB-driven excessive #GABA release inhibits #CNS repair after #SpinalCordInjury by suppressing BDNF-TrkB signaling, showing that MAOB deletion or its inhibitor #KDS2010 promotes recovery in animal models.

#OpenAccess #STTT: doi.org/10.1038/s413...

#VCoelhoSantosLab News 🚨

Maria started her Erasmus at Collège de France yesterday, joining Martine cohen-salmon ’s lab. She secured a 5-month stipend to work on exciting collaborative project in proteomics about #astrocytic endfeet development and #neurovascular coupling.
@ucoimbra.bsky.social

In 🐁, some #pericyte #PrimaryCilia penetrate #astrocytic #endfeet and reach the #neuropil - sometimes near #synapses! Could these #cilia act as sensory “antennae” 📡for #NeurovascularCoupling?
🧪🧵5/8

In 🐁🧠, #ultrastructure shows that #pericyte #cilia are often ensheathed by #astrocytic #endfeet. In 🚶‍♀️🧠, #astrocytes are swollen and cilia stay confined within the basal lamina. What are they sensing from the astrocytes?
🧪🧵4/8

The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...

Nice study in @nature.com that identifies #astrocytic ensembles that link experiences across days to stabilize #memory. #astrocytes #glia
www.nature.com/articles/s41...

Astrocytic mGluR5 signaling tunes emotional and cognitive processing in the adult brain The hippocampus is a brain region involved in both emotion regulation and higher cognitive functions. Astrocytes have emerged as active modulators of synaptic activity, capable of sensing, integrating...

We are excited to share our latest work showing:
1 - the existence of robust #mGluR5-dependent #astrocytic Ca2+ signaling in the #adult #brain that
2 - is involved in processing of #emotional and #cognitive behaviors
Fruitful collab with Gertru Perea

www.biorxiv.org/content/10.1...

Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior - Nature Neuroscience Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective manipulation of tagged astrocyte...

An #astrocytic ensemble that emerges in the nucleus accumbens upon activity during cue-motivated behaviors and is essential for modulating cue-reward associations 🧪🧪

www.nature.com/articles/s41...