Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡
Team effort with the labs of Marc Beyer and Ralf Stumm 👇
doi.org/10.1084/jem....
@limes-bonn.bsky.social @immunosens.bsky.social #immunosky

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Exciting work from Sue Kaech’s lab @tcellogic.bsky.social

Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses

#immunometabolism #immunosky

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...

CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus Thymic eviction explains CD8 T cell tolerance and why autoreactive CD8 T cells appear in the periphery but not the thymus.

#TCR #crossreactivity "Premature #thymic #eviction is the basis for #CD8Tcell tolerance and is the mechanism responsible for the appearance in the periphery of mature CD8 T cells bearing #autoreactive #TCRs that are absent from the thymus" www.science.org/doi/10.1126/...

#influenza #immunology #Immunity #Aging #SciComm #Openaccess #H2020 #WomenInSTEM #Tcell #CD8TCell