📅 OCT 15 | 11:00-11:15 AM | Room 258ABC
Logan Blaine presents "PerTurbo: A scalable Bayesian framework for whole-transcriptome differential expression analysis & optimal design of single-cell CRISPR screens"
#CRISPRscreen #SingleCell #ASHG2025

CRISPR screen identifies BAP1 as a deubiquitinase regulating SPIN4 stability
Ramirez, F., Sanchez, A. et al.
Paper
Details
#CRISPRScreen #BAP1Deubiquitinase #SPIN4Stability

Check out the preprint for all the data, figures, and amazing co-authors!
@brownlab1.bsky.social #ImmunoOncology #CRISPRscreen #SpatialBiology #ECM #PDAC #CancerImmunology
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GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!