How Does Antiphospholipid Syndrome Affect The Body? (Beyond the Blood to Major Organs) How does Antiphospholipid Syndrome affect the body? Whilst APS is a blood clotting disorder, it is also a systemic autoimmune disease.

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome

Is it a pedestrian death to freeze to death on sidewalk if no collision was involved ?

Hot take: #Cutaneous dermal injuries (sun damage, melanomas, etc) are the most common pededstrian injury.

Another reason I enjoy night cycling. Why look sun-ravished when you can settle for wind-beaten ?

Assessment of seasonal variation in #cutaneous #microvasculature function in healthy adults shows lower #nitricoxide mediated cutaneous #vasodilation in winter/early-spring compared to summer/early-fall.

doi.org/10.14814/phy...
#Endothelium

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO

@achronicvoice.com
#AntiphospholipidSyndrome

The Beacon trial is notable for a few reasons. First, it’s the first industry-sponsored, placebo-controlled study to deliver a clearly positive readout in CS. Second, the magnitude and speed of response stood out. At 16 weeks, patients receiving brepocitinib 45 mg saw a 22.3-point mean improvement on the CSAMI-A score versus just 0.7 points on placebo, with statistically significant separation as early as Week 4. Every patient in the 45-mg arm achieved a clinically meaningful ≥10-point improvement. For context, CSAMI-A ranges from 0 to 165 and captures both disease activity and lesion severity. On the Investigator’s Global Assessment, 69% of patients on 45 mg improved by at least two points to a score of clear or almost clear—another strong signal in a disease where disfiguring skin lesions can drive real psychosocial burden. Even the lower 15-mg dose showed meaningful improvement, while placebo patients saw minimal benefit, reinforcing a clear drug effect and dose response. Analysts have called the data “exceptional,” and clinicians involved described it as a “watershed moment” for a historically neglected disease. Proivant plans to move into Phase 3 after FDA discussions later this year. With prior Phase 3 success in dermatomyositis and ongoing development in noninfectious uveitis, brepocitinib is quietly shaping up to be a very important asset in immune-mediated inflammatory disease. Curious to see how regulators view the Phase 2 package—and whether CS could become another meaningful label expansion down the line.

Proivant Therapeutics just reported very strong Phase 2 data for brepocitinib in cutaneous sarcoidosis (CS)—a condition with no FDA-approved treatments and limited off-label options today.

#BCIC #cutaneous #sarcoidosis

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO

@AChronicVoice
#AntiphospholipidSyndrome

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO

@achronicvoice.com
#AntiphospholipidSyndrome

Typical of CREEPING ERUPTION, OR #CUTANEOUS #LARVA MIGRANS.

The patient was treated with albendazole. After 2 weeks, the lesion healed completely. No recurrence was seen at a 2-month follow-up visit.
2/2

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO

@achronicvoice.com
#AntiphospholipidSyndrome

"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO

@achronicvoice.com
#AntiphospholipidSyndrome

Training, Cleansing, and the Cutaneous Microbiome: Implications for Athlete Skin Health, Infection Risk and Performance: A Review - Premier Science Athlete skin microbiome, cutaneous microbiome, Sports dermatology, Dysbiosis in athletes, Probiotic therapy for athletes, Athlete skin infections.

doi.org/10.70389/PJS...

#cutaneous #microbiome #athleteskin #infectionrisk

"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome. 40% of APS patients who have #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant": buff.ly/XofExpO

Via @achronicvoice.com

"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO

How Does Antiphospholipid Syndrome Affect The Body? (Beyond The Blood To Major Organs) How does Antiphospholipid Syndrome affect the body? Whilst APS is a blood clotting disorder, it is also a systemic autoimmune disease.

"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO

@achronicvoice.com

Redirecting

New collab out with Jennifer Zhang & Amy Petty of @dukemedschool.bsky.social #Dermatology Department! #scRNAseq performed by #DukeMGC

'Insights into #Keratinocyte and Immunologic Landscape in #Cutaneous #Graft-Versus-Host Disease through #SingleCellTranscriptomics' 🧬💻

doi.org/10.1016/j.xj...

Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-versus-host Disease through Single Cell Transcriptomic Cutaneous manifestations are the most common presenting sign of chronic graft-versus-host disease (cGVHD) and the extent of cutaneous involvement is a…

Amy Petty, postdoc of Jennifer Zhang's lab, 2025 publication inspired the talk - 'Insights into complex #keratinocyte landscape in acute and chronic #cutaneous #GVHD through single cell RNA sequencing’: sciencedirect.com/science/arti...

Severe cutaneous adverse reactions (SCAR) • COUNCIL FOR INTERNATIONAL ORGANIZATIONS OF MEDICAL SCIENCES In clinical practice, there is mounting concern in relation to the burden of SCAR in relation to novel biologics as well as the increasing cost of

In clinical practice, there is mounting concern about the burden of severe #cutaneous adverse reactions (SCAR). This #CIOMS consensus report provides insights and latest thinking on this important topic in #medicine and #pharmacovigilance
cioms.ch/publications...

Antiphospholipid Syndrome (It's Not 'just' A Blood Clotting Disorder) - Learn More On: achronicvoice.com . (A plastic figurine of a human torso with organs exposed is in the background.)

" #Skin -related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome ..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant": buff.ly/2G7uuiB

#ChronicIllness

This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. Image credit: A. Fisher/Science Immunology

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...

Adagrasib-induced photodistributed hyperpigmentation: Two case reports and pathogenetic hypothesis Adagrasib-induced photodistributed hyperpigmentation: Two case reports and pathogenetic hypothesis

Letter to editor
Adagrasib-induced photodistributed hyperpigmentation: Two case reports and pathogenetic hypothesis
#Adagrasib #Skin #Hyperpigmentation #TargetedTherapy #ProteinKinaseInhibitor #Cutaneous #ADRs
www.em-consulte.com/article/1717...

In our January issue: Parasite of the Month: #Leishmania #amazonensis, the #etiological #agent of #cutaneous #leishmaniasis #CL & #anergic #diffuse CL #ADCL, authored by M.S.A. Garcia, V.A.O. Filho, M.B.C. Brioschi, K. Minori & D.C. Miguel @unicampoficial.bsky.social

www.cell.com/trends/paras...

Definition of cutaneous cutaneous relating to or existing on or affecting the skinnnn #definition #meaning #cutaneous #ielts #learnenglish #education #british

cutaneous
- Relating to or existing on or affecting the skin

Learn More...

#definition #cutaneous #meaning #english #ielts

Cutaneous Lesion Distribution in Clinical Assessment for Cardiac Sarcoidosis This case series explores the association between sarcoidosis-specific cutaneous lesions and cardiac sarcoidosis.

Pacientes con sarcoidosis cardíaca tienen sarcoidosis en la cabeza y centro de la cara y nariz, sin diferencias según raza o etnia, por lo que deben ser referidos al cardiólogo #sarcoidosis. #cutaneous #cardiac jamanetwork.com/journals/jam...

Climate Change, Floods, and Human Health | NEJM With climate change, exposure to floods has increased and is linked to adverse health outcomes, such as injuries, diseases, and mental health harms, all of which are greater in vulnerable populations.

Comprehensive look at health effects from #flooding -

#Infections...

#waterborne
#mosquito-borne
#rodent-borne
#cutaneous
#respiratory
#gastrointestinal

Fecal pathogens -> water bodies
Surface runoff -> pathogens -> downstream collection systems

#IDSky

www.nejm.org/doi/full/10....

Pharmacovigilance
Acute generalized exanthematous pustulosis: Analysis of cases managed in a Tunisian tertiary hospital
em-consulte.com/article/1638...
#AcuteGeneralizedExanthematous #Pustulosis #Drug #Bites #Severe #Cutaneous #ADRS
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