MrkA enhances the virulence phenotype of #carbapenem -resistant #Klebsiella pneumoniae both in vitro & in vivo.

MrkA drives CRKP virulence by linking iron uptake, adhesion & carbon metabolism, with deletion sharply reducing pathogenicity.

www.sciencedirect.com/science/arti... #OpenAccess #MicroSky

Therapeutic challenges & Emerging Strategies against #Carbapenem -Resistant #Acinetobacter baumannii.

Emerging agents like sulbactam‑durlobactam, eravacycline & cefiderocol offer new options against multifaceted CRAB resistance.

www.sciencedirect.com/science/arti... #OpenAccess #MicroSky

Scientists home in on Acinetobacter baumannii's resistance evolution Acinetobacter baumannii is a bacteria which can become a virulent killer in health-care settings among severely ill patients. The germ has rapidly developed drug resistance to even last-line…

Homing in on #Acinetobacter baumannii's resistance evolution ...

| #bacteria | #Healthcare | #patients | #carbapenem | By @hackensackmeridianhealth.org via @sciencex.bsky.social

Fig. 1 from https://www.nature.com/articles/s41467-025-66874-7. A) shows a map of the world, with the distribution of IMP variants. B) shows a stacked column graph of IMP variants over time (1996-2023). C) shows the number of IMP-positive genomes over time, by geographic region.

(2/7) Read this if:
- You are interested in #carbapenem resistance or #AMR
- Love #plasmids or #MGE
- Work on #OneHealth
- Want to learn about the global distribution of antimicrobial resistance and its spread
- Enjoy #DataVis

Things are starting to heat up though. Lots of evidence that the resistance combination to both #carbapenem (s) and tigecycline is rising:

Longitudinal surveillance of #carbapenem -resistant #Serratia marcescens in neonatal intensive care units:

Transmission routes and effective control strategies

www.sciencedirect.com/science/arti... #OpenAccess #MicroSky #MedSky

Experimental evolution uncovers how bacteria develop drug resistance The bacteria Acinetobacter baumannii (A. baumannii) is a haunting presence in many hospitals in the United States, where more than one in 100 patients are treated for A. baumannii infections. This…

Experimental #evolution uncovers how #bacteria develop #drug resistance ...

| #drugresistance | #Acinetobacter | #infections | #antibioticresistance | #carbapenem | By @sbpdiscovery.bsky.social via @sciencex.bsky.social

Superbugs thrive as access to antibiotics fails in India Antibiotics are overused by some and out of reach for others - fuelling resistance and leaving deadly gaps in care.

Deadly #superbugs thrive as access to #antibiotics falters in #India ...

| #bacteria | #antibioticresistance | #microbes | #drugs | #carbapenem | Via bbc .com