REST, UCHL1 & Cardiac Hypertrophy
A new study reveals that REST, a transcriptional repressor, downregulates UCHL1, helping control inflammation and fibrosis during cardiac hypertrophy. doi.org/10.1016/j.ge...
#REST #UCHL1 #CardiacHypertrophy

Key point: Cardiac alterations at structural and molecular levels were found in two epilepsy models with different mechanisms of induction.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #animalmodels #cardiacfibrosis #cardiachypertrophy #ionchannels #postSE

My continued biomedical education

Long non-coding RNAs in #CardiacHypertrophy & #HeartFailure: functions, mechanisms & clinical prospects

Da-Zhi Wang lab #NatRevCardiol 2024
www.nature.com/articles/s41...

#Cardiomyocyte #Thrombospondin-3 overexpression
⏫#ERStress🫀
⏫Pressure-induced #CardiacHypertrophy
⏫Functional impairment post-MI
Via
⏬Integrin expression+membrane trafficking
⏫Membrane instability (Evans blue uptake)

Thbs1/2/3/4/5 quinte KO🐭!! 💸🤑

#NatureComms 2019
www.nature.com/articles/s41...