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An overview of T cell exhaustion, its mechanisms and implications in #Cancer, #ChronicInfections, and #AutoimmuneDiseases, with discussion into the challenges and future research directions to improve T cell function.

#STTT #OpenAccess: doi.org/10.1038/s413...

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Patient thinks chronic fatigue is "just stress." Standard blood work comes back normal. Plot twist: Hidden chronic infections like Bud-Chiari disease that regular doctors completely miss. The Skolnikoff Method finds what others don't even test for.


#ChronicInfections #HiddenIllness

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New target identified for the development of specific immunotherapies Find out more!

🎯 Target for #immunotherapy:

A #MedUniVienna study shows #HDAC1 supports antiviral #Tcells under chronic infection & exhaustion. Published in @jem.org, findings may aid development of therapies for #chronicinfections like #HIV, #HepatitisB & #HepatitisC. ⬇️

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Did you know infections like Bartonella form biofilms that make them resistant to antibiotics?

Get the scoop on how imaging & lab testing are revolutionizing treatment.

Check out this episode of Made to be Whole to learn! #MedicalScience #ChronicInfections #madetobewhole

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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

Rewiring exhausted T cells to create therapeutic innovations for #ChronicInfections & #CancerTreatment doi.org/10.1126/scii... @ejohnwherry.bsky.social #ImmuneHealth #TranslationalScience

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I have Severe Sjogrens For 35 years. #Alopecia totalis for over 25 years. I have survived despite also having #PsoriaticArthritis,#Psoriasis and #SjogrensSyndrome too. The last 20 years I have been hunted by #ChronicInfections due to having to take #immuneSuppressants.

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