Social stimulation promotes #NLG1 proteolysis; the resulting NLG1-CTD maintains #SocialMemory by inhibiting #cofilin to strengthen dendritic spines, offering insight into memory maintenance mechanisms. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

#SocialInteraction triggers α- and γ-secretase cleavage of NLG1 in the #VentralHippocampuss, generating NLG1-CTD that inhibits #cofilin to strengthen #spines and maintain long-term potentiation and #SocialMemory. @utoronto.ca

#OpenAccess in #STTT: doi.org/10.1038/s413...

Activation of Piezo 1 in the Pathogenesis of Glaucoma Glaucoma is an eye disorder that damages the retinal ganglion cells and the optic nerve, and can cause vision loss or blindness. However, a lack of understanding of the underlying pathogenetic mechanisms has hampered the development of effective therapies.

🔓📄 'Activation of Piezo 1 in the Pathogenesis of Glaucoma' - an article published in 'Neuropharmacology and Therapy' on #ScienceOpen:

🖇️ #GlaucomaResearch #Piezo1 #CalciumSignaling #Cofilin

Segregating AND Combining the impacts of Pressure (Ca2+) vs #MatrixStiffness (RhoA-LIMK) on #SmoothMuscleCell phenotypic plasticity

Converging on #Cofilin #Podosome Mechanosensing

Nice Intro to SMC #Mechanobiology🤓

#ScienceAdvances 2022
www.science.org/doi/10.1126/...