Controlled Seeding of β-Amyloid Fibrillation Reveals Propagation of Structural Polymorphisms in Cellular Environments pubmed.ncbi.nlm.nih.gov/41941608/ #cryoEM

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels pubmed.ncbi.nlm.nih.gov/41941269/ #cryoEM

A Workflow for Visualizing Protein Conformational Dynamics from Cryo-EM Maps Using Human Asparagine Synthetase pubmed.ncbi.nlm.nih.gov/41941364/ #cryoEM

Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519 pubmed.ncbi.nlm.nih.gov/41941628/ #cryoEM

Structural insights into single-pass transmembrane receptor GC-A activation by distinct antihypertensive antibodies pubmed.ncbi.nlm.nih.gov/41942428/ #cryoEM

Cryo-EM structure of a photosystem I supercomplex from Euglena gracilis containing pentameric LHCE and dimeric LHCII pubmed.ncbi.nlm.nih.gov/41942460/ #cryoEM

A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design www.biorxiv.org/content/10.64898/2026.04.02.716066v1 #cryoEM

Achieving Near-Atomic Resolution in Single-Particle Cryo-EM Using a Single Micrograph Single-particle cryo-electron microscopy (cryo-EM) typically requires the acquisition and analysis of a large number of micrographs to achieve high-resolution three-dimensional (3D) reconstructions of

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Achieving Near-Atomic Resolution in Single-Particle Cryo-EM Using a Single Micrograph #cryoem

(~ 300-400 particles for apo-ferritin or 20S proteasome)

langtaosha.org.cn/lts/en/prepr...

Here you can see a cryoEM structure of human pannexin 3 (PDB code: 9JCH)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #pannexin #cryoem #mediator #linker #response

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels www.biorxiv.org/content/10.64898/2026.04.04.716525v1 #cryoEM

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα www.biorxiv.org/content/10.64898/2026.03.31.714456v1 #cryoEM

Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNFα NANOBODY® compound pubmed.ncbi.nlm.nih.gov/41935434/ #cryoEM

Blender Rendering of vitrified HA trimer with DM at the air-water interface

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

A salt bridge pre-arranges the structure of the ABC transporter BmrA for proper NBD dimerization pubmed.ncbi.nlm.nih.gov/41935664/ #cryoEM

Molecular mechanisms and therapeutic potential of proton-sensing GPCRs pubmed.ncbi.nlm.nih.gov/41935875/ #cryoEM

New in @jgp.org: Behringer et al. @tuda.bsky.social review how coarse-grained computational methods uncover long-range mechanical connectivities in HCN channels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article-...

Behringer et al. from @tuda.bsky.social show how coarse-grained computational methods uncover long-range mechanical connectivities in HCN #IonChannels. Together with high-res #cryoEM structures, these methods provide insights into their allosteric regulation. rupress.org/jgp/article/...

Ansamer-Controlled Bicyclic Peptides as Integrin αvβ6 Targeting Agents pubmed.ncbi.nlm.nih.gov/41937119/ #cryoEM

DM: a simple solution to suppress air-water interface interactions in cryo-EM www.biorxiv.org/content/10.64898/2026.04.02.716008v1 #cryoEM

Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA www.biorxiv.org/content/10.64898/2026.04.02.716132v1 #cryoEM

Spent too much time in situ and forgot the level of detail you get with SPA 🍩
#cryoEM

2D classes of a 58 kDa particle collected on a 100 kev Tundra electron microscope

2D classes of the 58 kDa sample collected on the 100 keV Tundra TEM with a Falcon C detector at @nusbf.bsky.social @newcastleuni.bsky.social. Still much work to do to optimise the sample & data collection but its cool to see what a 100 keV TEM is capable of. #cryoEM @recon4imd.bsky.social

Spin-labeling studies implicate a highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction www.biorxiv.org/content/10.64898/2026.04.01.715611v1 #cryoEM

Cryo-ET reveals distinct Gag lattice architectures in virus-like particles and immature HIV-1 pubmed.ncbi.nlm.nih.gov/41928506/ #cryoEM

Apical Localization of RNA Polymerases Modulate Transcription Dynamics and Supercoiling Domains Revealed by Cryo-ET pubmed.ncbi.nlm.nih.gov/41929223/ #cryoEM

Using Cryogenic Electron Tomography (cryoET) to Determine Rubisco Polymerization Constants in alpha-Carboxysomes pubmed.ncbi.nlm.nih.gov/41929154/ #cryoEM

The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing pubmed.ncbi.nlm.nih.gov/41929118/ #cryoEM

MscM uses a novel gating mechanism for bacterial mechanosensitive channels pubmed.ncbi.nlm.nih.gov/41928924/ #cryoEM

Variable Resolution Maps (VRM) in CCTBX and Phenix: Accounting For Local Resolution In cryoEM pubmed.ncbi.nlm.nih.gov/41928950/ #cryoEM

Suppressing Transfer of Antibiotic Resistance by a Small RNA Virus pubmed.ncbi.nlm.nih.gov/41928967/ #cryoEM