HP1 isoforms direct repair pathway choice in response to #heterochromatin double-strand breaks. New study from Darshika Bohra and Aprotim Mazumder @tifrhyderabad.bsky.social: rupress.org/jcb/article/...

#Chromatin #epigenetics #DNAbiology #DNArepair

Stage- and tissue-specific gene editing using 4-OHT inducible Cas9 in whole organism. New study from Yaqi Li, Weiying Zhang, Zihang Wei, Anming Meng, Xiaotong Wu @tsinghuauniversity.bsky.social and colleagues: rupress.org/jcb/article/...

#Development #DNAbiology #CRISPR #Zebrafish

LncRNA EGFR-AS1 promotes DNA damage repair by enhancing PARP1-mediated PARylation, say Kun Gao, Changying Guo (Xinjiang University), Liang Jin (China Pharmaceutical University) and colleagues: rupress.org/jcb/article/...

#Biochemistry #Cancer #DNAbiology #RNAbiology

ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the #FanconiAnemia pathway. From Moonjung Jung, Jungwoo Kim, Agata Smogorzewska @rockefelleruniv.bsky.social‬ and colleagues: rupress.org/jcb/article/...

#CellMetabolism #DNAbiology #Disease #Genetics #DNADamage