Euglena gracilis as a high-throughput screening platform for antibacterial activity, cytotoxicity and membrane permeability in a one-step and cost-effective assay - The Journal of Antibiotics The Journal of Antibiotics - Euglena gracilis as a high-throughput screening platform for antibacterial activity, cytotoxicity and membrane permeability in a one-step and cost-effective assay

www.nature.com/articles/s41...
Our #DZIF natural products library was recently used to evaluate a novel bioassay using Euglena in a multi-purpose screen for antibiotics discovery with which we can measure multiple bioactivities at the same time. The results were published in J. Antibiotics.

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway To tackle the emerging resistance against existing antibiotics, we screened natural-product (NP) libraries against two underexploited target enzymes from the 2C-methyl-d-erythritol 4-phosphate (MEP) pathway, namely, Mycobacterium tuberculosis DXPS and Escherichia coli IspD. We have chosen these two enzymes due to the availability of the crystal structures that helped to elucidate the putative binding modes of the NPs identified. The screening of a NP collection led to the discovery of myxobacteria-derived maracen A and Streptomyces-derived polyketomycin as the first NPs targeting these enzymes.

pubs.acs.org/doi/10.1021/...

Our #DZIF natural product library was recently screened against two target enzymes from the MEP pathway. This led to the discovery of the first natural compounds targeting these enzymes. The results were published in ACS Med Chem Lett. Congrats to all co-authors!

Zwei inspirierende Tage bei der Gemeinsamen DZIF/PEG-Jahrestagung 2026 in Bonn! 🧫🌍
Spannende Impulse zu Infektionsforschung, Resistenzen, Innovationen und globalen Herausforderungen. Großer Dank an alle Beteiligten.

#DZIF #PEG #Infektionsforschung #AMR #GlobalHealth #Science

Spannender Vortrag von Laman Rahimli beim DZIF/PEG Meeting 2026: Outcomes invasiver Candida-Infektionen in Europa und den USA – erste Einblicke aus einer laufenden multinationalen Studie (2024–2026). Klinisch hochrelevant!
#Candida #InfectiousDiseases #DZIF #PEG #ClinicalResearch #Mycology

Starker Vortrag gestern von PD Dr. Sibylle C. Mellinghoff zur Dauer des Pneumokokken-Schutzes bei Hämodialysepatient:innen (DOPPIO-Studie) beim gemeinsamen DZIF/PEG-Meeting 2026. Großartige Wissenschaft, echte Relevanz!
#InfectiousDiseases #DZIF #PEG #Vaccination

The DZIF/PEG Joint Meeting 2026 final program is online!
Top keynotes, focused symposia & infectious disease insights.
Explore the highlights: dzif-peg-annual-meeting.de/programme-ab...
#InfectiousDiseases #DZIF #PEG

Mannich Medal for Rolf Müller | German Center for Infection Research Prof.

🎉 #Congratulations to #DZIF scientist Prof. Rolf Müller on receiving the Mannich Medal for his outstanding achievements in pharmaceutical sciences and antibiotic research.

@helmholtzhzi.bsky.social @helmholtzhips.bsky.social
t1p.de/mvodc

They reported on the progress made in the global fight against the Mpox virus: Prof. Yazdan Yazdanpanah (ANRS MIE), Prof. Marylyn Addo (DZIF), Prof. Ayola Akim Adegnika (DZIF), Prof. Maura Dandri (DZIF), Prof. Asisa Volz (DZIF), PhD Emmanuel Nakouné (Institut Pasteur de Bangui), Prof. Jade Ghosn (Université Paris Cité), Dr. Jeanne Postal (Institut Pasteur), Dr. Timo Jäger (DZIF). @upcite.bsky.social @pasteur.fr © DZIF

🤝 #DZIF & @anrs-mie.bsky.social at #ECTMIH2025 in Hamburg: At their joint symposium on September 29, researchers from ANRS MIE and DZIF presented new insights into #mpox, a viral disease recently declared a "Public Health Emergency of International Concern" by #WHO.
🔗 Read more: t1p.de/nxa2u

Chris McGuigan Drug Discovery Award for Heidelberg virologist Stephan Urban | German Center for Infection Research On September 18, Prof. Dr. Dr. h.c.

🎉 Congratulations 👏! Heidelberg virologist and #DZIF professor Stephan Urban has won the Chris McGuigan Drug Discovery Award for his groundbreaking work on Hepcludex© (bulevirtide), the first approved therapy for chronic hepatitis D.
🔗 Read more: t1p.de/gdojz

#DrugDiscovery #Virology #Hepatitis

Institut für Infektions- und Tropenmedizin

Safer options for #MDRTB: Studies show sutezolid & delpazolid are as effective as linezolid but better tolerated. A milestone for future TB therapy. 👉 www.lmu-klinikum.de/tropeninstitut
#TBResearch #GlobalHealth #DZIF

🔬 Don’t miss your chance to present at the DZIF / PEG Joint Meeting 2026 in Bonn!
🗓 Abstract deadline: Aug 15, 2025 | Poster: Sept 30, 2025
🎟 Submit, register & book now:
👉 dzif-peg-annual-meeting.de
#InfectionResearch #DZIF #PEG2026

Susanne Herold admitted to the German National Academy of Sciences Leopoldina | German Center for Infection Research Prof. Dr. Dr. med.

🎉Congratulations to #DZIF scientist Prof. Dr. Susanne Herold on her election to the #Leopoldina, honoring her outstanding scientific achievements in the field of infection and lung research. 🫁

👏 @heroldlab.bsky.social @jlugiessen.bsky.social @ukgm.bsky.social @proloewe.bsky.social @leopoldina.org

DZIF / PEG Joint Meeting 2026

Jetzt anmelden! 🎉
Die Registrierung für das DZIF / PEG Joint Meeting 2026 in Bonn ist jetzt möglich – erstmals gemeinsam mit der PEG.
🔗 Infos & Anmeldung: dzif-peg-annual-meeting.de

#DZIF #PEG2026 #Infektiologie #Konferenz

Virologist Prof. Schindler and a colleague evaluate data from an infection experiment. © Universitätsklinikum Tübingen/Verena Müller

#DZIF #researchers developed computer models of #RNA #virus replication in the #cell metabolic context and predicted drug targets. Comparison to drug databases revealed two broad-spectrum candidates: phenformin and atpenin A5.

👉 t1p.de/9nkyo

#InfectionResearch #Science @kaletalab.bsky.social

Postdoctoral researcher (f/m/x) We are looking to support our rapidly growing team as soon as possible:

🧪 Das Team der Uniklinik Köln sucht Verstärkung:
Postdoc (w/m/x) im Bereich Klinische Infektiologie mit Fokus auf Impfungen bei immunsupprimierten Patient:innen
💼 100 %, TV-L
🔗 Jetzt bewerben: jobs-uk-koeln.onlyfy.jobs/job/mcrrj38x...
#DZIF #Stellenangebot #Infektiologie #Postdoc

After a long journey, we've reached an important milestone with this publication. I'm grateful for the excellent collaboration between neurology, neuropathology, radiology and our team at the #CharitéVirology #DZIF #LaborBerlin

At #ESCMID2025, Louise Cremer presented new data on the immunogenicity of COVID-19 vaccination in immunocompromised patients – an important step toward protecting vulnerable groups. #DZIF #InfectionResearch #BonnCologne

Louise Cremer präsentierte auf der #ESCMID2025 neue Daten zur Immunogenität der COVID-19-Impfung bei immungeschwächten Patienten – ein wichtiger Beitrag zum Schutz vulnerabler Gruppen. #DZIF #Infektionsforschung #BonnKöln

Wir freuen uns, dass Louise Cremer vom DZIF-Standort BonnKöln ihre Forschung zur COVID-19-Impfung bei immungeschwächten Patient:innen auf der #ESCMID2025 in Wien präsentiert – unterstützt durch ein DZIF-Reisestipendium! #DZIF #InfectionResearch #ESCMID2025 @dzif.bsky.social

📢 Rückblick: DZIF Standorttreffen Bonn-Köln 📢
Beim Treffen am 26. März 2025 standen aktuelle Entwicklungen, neue Förderphasen und wissenschaftliche Projekte im Fokus. Besonders diskutiert: DZIF-OSRA, ein neues Flagship-Projekt und biomarkerbasierte Studien. #DZIF #Forschung #Wissenschaft

Thank you @gesvirologie.bsky.social for giving me the opportunity to present our data on the preclinical efficacy of an MVA-based vaccine approach against Marburg virus.
Proud to be part of this great collaboration with the Volz lab, TiHo Hannover.
#gfv2025 #dzif

The picture shows the granuloma structure and distribution of the antibiotic BTZ-043 in four differently stained tissue sections of two tuberculosis granulomas. The stains show the necrotic granuloma centers, connective tissue capsules, immune cell layers and the accumulation of BTZ-043 in the entire granulomas.

🔥 Breakthrough in TB research! The antibiotic BTZ-043 reaches hard-to-treat granulomas and fights bacteria even in necrotic tissue. This is a major step toward more effective TB therapy! 🚀🦠

🔎 Read more in Nat Commun (@naturecomms.bsky.social): doi.org/10.1038/s414...

#TB #BTZ043 #DZIF #LeibnizHKI

Preparing to speak in Munich - not at the Security Conference (!) but at #DZIF on Gender Differences in HIV. Thank you to organisers for the invitation to this prestigious conference @BritishHIVAssoc #HIVinWomen #HIVTestingWeek

AT the #DZIF 2025 conference, we just had the privilege to listen to STewart Cole from Institute @pasteur.fr talking about Antimicrobial resistance #AMR. This is a massive risk for our society, but the financial incentives are skewed and most pharma has been divesting from antibiotic development.🧪

Product Development Unit (#PDU) Campfire at the #dgi/@dzif.bsky.social Annual Meeting as a service for #DZIF members! 🌟 More than 50 participants! 🔥 #PDUCampfire #DZIFMeeting #Networking

Thank you for joining us at our Infect-Net Campfire Session with @gabrielepradel.bsky.social et al. at the DGI/DZIF annual meeting in Munich 🤗💜🏕️ @dzif.bsky.social #DZIF We were impressed to meet so many of you!

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination - Cellular & Molecular Immunology Cellular & Molecular Immunology - MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

I'm very proud of my Postdoc Henning Jacobsen, who presented today our data on a #CMV based #vacine vector at the #DZIF meeting in Munich. Some data were published previously www.nature.com/articles/s41... , but now we show that our concept also works in hamster, not just in mice. More to come soon.

A 👀at important #research on #WorldNTD Day! With the #eWHORM project, the #DZIF is working with partners🤝from🌍to test innovative💊active ingredients like the former LOEWE-DRUID. unimarburg.bsky.social jlugiessen.bsky.social goetheuni.bsky.social thm.de fraunhofer.bsky.social @pei-germany.bsky.social

🚀 Big news in the fight against Epstein-Barr virus (EBV):

Start-up #EBViously, a spin-off from #HelmholtzMunich and the German Center for Infection Research (DZIF) @dzif.bsky.social, is officially launched!

👉 t1p.de/bgfbs

#Vaccine #Virus #EBV #Healthcare #Innovation #Startups #SpinOff #DZIF

Foto: Professorin Marylyn Addo, renommierte Infektionsmedizinerin und Impfstoffforscherin am Universitätsklinikum Hamburg Eppendorf (UKE) steht am Rednerpult mit einem Presenter in der Hand. Sie steht vor der Bildschirmpräsentation ihres Vortrags mit dem Titel Lost in Translation? Moving from bench to bedside - challenges and opportunities. Foto Credits: René Lesnik

#infectnetIV Recap: Are we lost in translation? Marylyn Addo vom Universitätsklinikum Hamburg-Eppendorf präsentiere einen Überblick über die Translationsprojekte des #DZIF: #Translation ist teuer, langwierig und erfordert effiziente interdisziplinäre #Teamarbeit! #Infektionsforschung #womeninSTEM 💜