Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease - Journal of Neuroinflammation Background Growing evidence indicates that Epstein-Barr virus (EBV), a gammaherpesvirus, plays a central role in the pathogenesis of multiple sclerosis (MS). The presence of EBV-infected cells in the ...

@bmc.springernature.com
link.springer.com/article/10.1...
The diversity of microglial activation states, including #darkmicroglia, is increasingly recognized in the context of viral infections.eg, in HIV infection, microglia form inflammatory nodules, release neurotoxins &

#Medsky🧪 #IDSky #Neurosky #publichealth
#Darkmicroglia are a distinct, stress-associated microglial state that emerges in #neurodegenerativediseases, #viralinfections, & #long’COVID.

#Darkmicroglia as an ultrastructurally distinct, highly active subset of microglia primarily associated with cellular stress & neurodegeneration. Identified by their condensed, electron-dense appearance under electron microscopy, DM be are identified by their distinctive ultrastructural appearance

#Neurodegeneration
#Alzheimer’s #Microglia
#DarkMicroglia
#IntegratedStressResponse #ISR #SRIInhibition
#Research #Neuroscience