Very successful weeks for @lcsolab.bsky.social members with poster awards for Christine Marty at @euromedchem.bsky.social #EFMCISCB25 conference and Pierre Palamini at the Swiss Industrial Chemistry Symposium of @swisschemistry.bsky.social
#EFMCISCB25 by @euromedchem.bsky.social and #AdvancesChemBio by @gfg-chembio.bsky.social were amazing conferences. I learned a lot about new science and connected with many inspiring scientists. Nevertheless, after 2 weeks of traveling, I am now happy to be home and not travel much in the next time.
Concluding remarks by Claudia Höbartner at #EFMCISCB25. Thanks to sponsors, exhibitors, committees, secretariat and, above all, participants that made this event a very successful one. See you again in 2027!
@euromedchem.bsky.social
@youngscinet.bsky.social
Topping off #EFMCISCB25 we had an exciting talk on #molecularglue #TPD from @monterosatx.bsky.social
Nice to see how rapidly the rational discovery and of #smallmolecule degraders is developing and the insight these platforms are providing into #biology @euromedchem.bsky.social
Great talk by Arnaud Gautier at #EFMCISCB25. He talked about his group's work on the CATCHFIRE technology, that allows chemical induction of protein (hetero)dimerization with simultaneous production of a fluorescent signal to monitor the dimerization. #ChemBio #chemsky www.nature.com/articles/s41...
Inspiring keynote lecture by Tom Lin from Washington University in St. Louis at #EFMCISCB25. He talked about the understudied posttranslational modification of protein arginylation and the development of a powerful chemoproteomic platform to study it proteome-wide. (1/4)
Great talk by Claudine Greenwood at #EFMCISCB25. An electrophile-first covalent fragment screen with sulfonyl fluorides to identify binders for LdBDF5. The hits were turned into probes for site-selective non-covalent screening, which yielded more advanced covalent derivatives by fragment merging.
Lovely talk on #fragment based #covalent strategy to drug Leishmania #bromodomain at #EFMCISCB25 this morning from Claudine Greenwood @glaxosmithkline.bsky.social . Great to see this strategy being used for neglected #infectiousdisease
Modification of CpG islands in DNA is an important epigenetic mark.
In his talk at #EFMCISCB25 by @euromedchem.bsky.social, Daniel Summerer talked about tools to readout the modification state of CpG islands on both DNA strands simultaneously. pubs.acs.org/doi/10.1021/...
#chemsky #ChemBio
Insightful talk by Ronald Micura at #EFMCISCB25 by @euromedchem.bsky.social. He talked about his group's exciting research into covalent binders to structured RNAs. They use alkyl halides and mesylates as tempered electrophiles for this application. www.nature.com/articles/s41...
An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation.
@euromedchem.bsky.social
Epigenetic modifications play a huge role in health and disease.
In her inspiring keynote lecture at #EFMCISCB25, @kawamuragroup.bsky.social talked about her group’s impressive research in the field on the example of 2OG oxygenases that act as lysine demethylases. (1/5)
The last day of #EFMCISCB25 by @euromedchem.bsky.social is off to a great start with an insightful keynote lecture by Cynthia Burrows. She talked about the use of nanopore sequencing to characterize chemically modified nucleotides in RNA. #chemsky #ChemBio pubs.acs.org/doi/10.1021/...
Chaired by Claudia Höbartner, the last day at #EFMCISCB25 starts with the PL by Cynthia Burrows (@uofupress.bsky.social) thrilling the audience with her nanopore studies on chemically modified RNA. @euromedchem.bsky.social
Great talk by @kathlab.bsky.social at #EFMCISCB25. She talked about her group's work on using artificial base pairs to site-specifically incorporate modifications into long RNAs by in vitro transcription e.g. to measure intramolecular distances by EPR. (1/2) onlinelibrary.wiley.com/doi/full/10....
Great talk by @alitavassoli.bsky.social at #EFMCISCB25. He talked about making cyclic 6-mer peptides in human cells using the SICLOPPS technology and directly using them for functional assays with downstream hit deconvolution by NGS. www.sciencedirect.com/science/arti...
Bifunctional proximity inducers are turning into a more and more important entity in drug discovery.
David Madge from WuXi AppTec gave a very interesting workshop at #EFMCISCB25, in which he introduced the most important concepts of the field. (1/4)
Interesting talk by Laszlo Petri from the group of György Keserű at #EFMCISCB25. He talked about the systematic design of a cysteine-directed covalent library with many different warheads and its use to find hits for various proteins. www.sciencedirect.com/science/arti...
@mvdstelt.bsky.social represented our LED3hub at #EFMCISCB25 with a great lecture. He talked about his group's work in chemical neuroscience and especially highlighted the work by @daanvandervliet.bsky.social on better understanding multiple sclerosis with multi-omics www.biorxiv.org/content/10.1...
Great talk by @mvdstelt.bsky.social at #EFMCISCB25. He talked about his group’s exciting research within the @led3hub.bsky.social and the iCNS consortium on chemical neuroscience. Great insights, how chemical tools and #ChemBio methods can shed new light onto the processes in the brain. (1/3)
Up next at #EFMCISCB25 @kjohnsson.bsky.social sharing #fluorescent tools for cell imaging and @mvdstelt.bsky.social from @unileiden.bsky.social showcasing #chembiol and #proteomics to understand #lipid signaling in the diseased brain.
I am happy that I had the chance to participate in the Career Panel Discussion organized by @youngscinet.bsky.social at #EFMCISCB25 together with Thais Gazzi, Christoph Dumelin and @kawamuragroup.bsky.social. Great to discuss all the diverse questions that the attendees were interested in. (1/2)
Great talk by @kjohnsson.bsky.social at #EFMCISCB25. He talked about his group’s work on recording transient cellular events for post hoc analysis. Great #ChemBio tools that allow to better understand quick events like those in neuronal communication. #chemsky (1/5) www.science.org/doi/10.1126/...
If you are #EFMCISCB25 @euromedchem.bsky.social , don't miss Christine's poster!
www.linkedin.com/feed/update/...
The 2nd day of #EFMCISCB25 is off to a great start with an inspiring lecture by Ben Davis. He talked about “Chemical mutagenesis” of proteins to introduce non-proteinogenic amino acids with diverse functions by chemically modifying proteinogenic amino acids. (1/6)
It was an honour to chair this career panel discussion session at the start of the second day at #EFMCISCB25
@euromedchem.bsky.social @youngscinet.bsky.social
Wow, part 2/2 of this keynote #EFMCISCB25 covered new research to edit #gycans on proteins through carbon #radicals opening up new opportunities in #chembiol !!
First up on day 2 of @euromedchem.bsky.social #EFMCISCB25 is Ben Davis from @ox.ac.uk talking about awesome #chemistry to edit #proteins eg. chemical #mutagenesis, such as Cys>Dha>Xxx transitions #chembiol #chemsky
The 2nd day at #EFMCISCB25 starts early with a Career Panel Discussion, featuring @stephanhacker2.bsky.social, @kawamuragroup.bsky.social, Cristoph Dumelin, and Thais Gazzi, chaired by Laia Josa Culleré.
@euromedchem.bsky.social
@youngscinet.bsky.social
Getting ready for day 2 of #EFMCISCB25. A great day ahead. My highlights will be being on the career panel by @youngscinet.bsky.social, the poster session as well as talks by Ben Davis, @kjohnsson.bsky.social, @mvdstelt.bsky.social, @alitavassoli.bsky.social and @kathlab.bsky.social. (1/3)
