🧬New from Li et al!
📄Epigenome-Wide Association Study of Blood Proteome in the #Atherosclerosis Risk in Communities Study
#EWAS #methylation
👉 bit.ly/4l5hgSu

Association of DNA methylation and musculoskeletal spinal pain at four timepoints during adolescence and early adulthood This study examined the association between epigenetic genome-wide DNA methylation with mechanism-based phenotypes of spinal pain from adolescence through early adulthood, accounting for confounder...

Our paper looking at the Association of DNA methylation and musculoskeletal spinal pain at four timepoints during adolescence and early adulthood #ewas www.tandfonline.com/eprint/7WDSY...

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#Epigenomics #EWAS #Methylation #Biomarkers #PopulationHealth #DiseaseResearch #Genomics

My advise if you review an #EWAS paper is to judge the plausibility of the results, the biology and the covariates used. And of course wether it is a big meta-analysis (a sample size of 1000 is enough to find robust findings) and/or replicate their results. We should stop to ask for pointless work

Dear genetic people, I love you but as an epigenetic enthusiast myself in addition to #gwas, I kindly remind you that QQplots and inflation factor in #EWAS are pointless and meaningless. So I would appreciate to stop asking for it. It s not useful.

Building on the work above, Prof Mutesa showed the #intergenerational transmission of epigenetic signatures through an #EWAS study (N=450) (Musanabaganwa et al 2021; PMID 34875875)
7/11

Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes - BMC Genomics Background Few studies have explored the association between DNA methylation and physical activity. The aim of this study was to evaluate the association of objectively measured hours of sedentary beh...

I am pleased to say that our cross-ancestry #EWAS of physical activity is published in BMC #genomics. We aimed to evaluated associations between #DNAmethylation and hours of sedentary behaviour and moderate activity in European and South Asian pregnant women.
#physicalactivity #health
🧬 & 🖥️ 🧪 🏃‍♂️🏋️‍♀️

I'm working on a 2-3h DNA methylation hands-on analysis workshop, and thinking of preparing a full-day one. What would people like to learn in depth? I'm including, sample randomization, QC, preprocess and analysis
#DNAmethylation #OmicAnalysis #EWAS #Academicsky

Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study Although there are some epigenome-wide association studies (EWAS) of insulin resistance, for most of them authors did not replicate their findings, and mos

Since there are not many hashtags with #EWAS, I will mention an article that we published two years ago, which I think it is very neat (of course I am very biased). We performed EWAS of insulin resistance in pregnancy across Europeans and South Asians 🧬 & 🖥️ .