Major updates on Neighbor #GWAS! Now it's combined with polygenic IGEs by RAINBOWR. Collaboration with Kosuke Hamazaki.
doi.org/10.64898/202...

Inclusion bias affects common variant discovery and replication in a health-system linked biobank We quantify inclusion bias in a health-system-linked biobank using classification models to distinguish enrolled individuals from the background population. To evaluate its impact on genetic findings ...

Inclusion bias in #GWAS of #EHR traits

"By weighting the sample using inverse probability weights derived from probabilities of enrollment, we replicate 54% more known GWAS variants" 😱

#statgen

www.cell.com/ajhg/fulltex...

#nature #genomics #precisionmedicine #healthequity #gwas #kidneydisease #kidneygenafrica #africangenomics #naturecommunications #datascience #globalhealth | Segun Fatumo I’m excited to share our latest work, published in #Nature Communications This study, delivered through the KidneyGenAfrica Consortium, represents the largest genome-wide association study (GWAS) of ...

KidneyGenAfrica rocks

👏 @sfatumo.bsky.social & team!

#ckd #africa #gwas

www.linkedin.com/posts/segun-...

#Monogram2026 finished with an innovative talk on engineering plant immune receptors from Jiorgos Kourelis @imperialcollegeldn.bsky.social (Rank Prize New Lecturer @rankprize.bsky.social ) and a sneak peak at a new GWAS tool from @ensembl.org #syntheticbiology #GWAS

There is high symptom and genetic overlap across psychiatric conditions. @andrewgrotzinger.bsky.social et al. (2025) explored this using our #GWAS data of over 1 mil cases across 14 conditions. They assessed the genetic architecture and the functional roles of genes across these conditions.

This 5-day course provides a practical introduction to the full #GWAS workflow, guiding participants from study design and data preparation to statistical analysis and interpretation of results.

www.physalia-courses.org/courses-work...

#GWAS #Bioinformatics #Rstats

1/5 Maria Koromina and colleagues investigated genome-wide significant hits that were associated with the likelihood of having BD from our recent #GWAS. They identified from the 64 associated variants 17 that likely played causal roles in bipolar development, implicating 23 different genes.

Last year researchers used our data to publish a paper in Nature Neuroscience mapping genetic variants identified from our previous #bipolar #GWAS to genes and exploring their likely functional effects

Just out.

Genetically determined ancestry is associated with different plaque morphology and molecular features.

In collaboration with @clintomics.bsky.social. @eassociety.bsky.social @umcutrecht.bsky.social #uva #plaque #atherosclerosis #GWAS #GeneSky doi.org/10.1016/j.at...

1/5 We analysed genetic data from over 158,000 people with bipolar disorder and 2.8 million controls, spanning European, East Asian, African American and Latino ancestries — the largest and most diverse BD #GWAS ever conducted.

New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways - PubMed Bipolar disorder (BD) is a highly heritable mental disorder that affects millions of people worldwide. Our understanding of the genetic etiology and biological processes that underlie BD have greatly increased in recent years. Extensive progress has been made in identifying common variant signals fo …

📄 O'Connell, et al., Biological Psychiatry (2025) 🔗 pubmed.ncbi.nlm.nih.gov/40456304/
#BipolarDisorder #Genomics #MentalHealth #Psychiatry #GWAS

Academician Lusheng Huang team at #JiangxiAgriculturalUniversity unraveled genetic underpinnings of purine content in #pork
🐖🔗 doi.org/10.1016/j.ji...
#QTLs #GWAS #pig #genetic

Genome-wide association study reveals #genomic regions for #nitrogen, #phosphorus and #potassium use efficiency in bread #wheat
🌟🌈☀️ doi.org/10.1016/j.ji...

✏️Jili Xu et al. #PlantScience #NUE #QTL #GWAS

New in #G3journal: Brooke et al. performed #GWAS on the Wild Barley Diversity Collection to identify novel stem rust resistance loci and candidate genes that are effective against a virulent isolate from the Pacific Northwest population. buff.ly/k7nyw4y

A Developmentally Informed Study of Sleep and Circadian Polygenic Scores in Adolescence This study uses polygenic scores derived using summary statistics from large adult genome-wide association studies to examine whether genetic variants that are associated with adult sleep phenotypes a...

Genetic variants identified in adult #GWAS may be relevant to #sleep phenotypes in #adolescents. Great work by Katie Lewis! @sleep-rhul.bsky.social @rhulpsychology.bsky.social

jamanetwork.com/journals/jam...

In a study published in Horticulture Research (Oxford University Press, 2025), researchers from Nanjing Agricultural University and collaborating institutions conducted a large-scale genomic analysis of rooting traits in chrysanthemum.
#Chrysanthemum #GWAS
Details: doi.org/10.1093/hr/u...

I love seeing #gwas folks come around to AI after years & years of bashing it. They could have been part of the solution...

Experimental set-up. 3 to 5-day-old virgin flies were collected and separated into groups of ten by sex, using ten vials of ten flies per sex/genotype/treatment combination. Flies in the exercise-treated group underwent five consecutive days of exercise using the Treadwheel, while animals in the control group were handled the same way, but without the treatment on the Treadwheel. 1 day after completing the exercise treatment, climbing ability of all animals was measured. At this point, the animals were weighed and frozen for metabolite analysis.

James Walts & co use #Drosophila melanogaster to investigate how exercise impacts body composition, specifically, protein content. doi.org/10.1242/bio....

#ExercisePhysiology #Metabolites #TreadWheel #GWAS

NG00179 - AD GWAS in participants of African ancestry – Ray et al., 2024 - DSS NIAGADS The p-value only files are available in the “Open Access Dataset” tab.To access the full data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00179) in the “Choose a Dataset” section.Once approved,

The genetics of Black Americans often goes unstudied when looking at Alzheimer's. This #GWAS now available in DSS looked at almost 10,000 participants, using SNPTEST to find genetic variants in people with African ancestry. #genomics
dss.niagads.org/datasets/ng...

A new study in #GENETICS showcases CARLIS, a comprehensive covariate-assisted replicability analysis method, to enhance statistical rigor and biological interpretability while maintaining asymptotic false discovery rate control in #GWAS. buff.ly/9irG1wb

Commentary
Genomics of kidney volumes: one size does not fit all

doi.org/10.1016/j.kint.2025.12.003

Original article: doi.org/10.1016/j.kint.2025.08.038

#NephSky #MedSky #GWAS #kidneydisease

#FruitRes
Genome-wide association studies in 71 citrus varieties reveal 125 loci and 189 genes linked to photosynthesis-related traits.
Details: maxapress.com/article/doi/10.48130/fru...
#CitrusGenomics #Photosynthesis #GWAS #PlantPhysiology

New study finds valvular heart disease, hypertensive heart disease, and endocarditis increase risk of systemic lupus erythematosus, reveals shared genetic links.
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch

Sharing our pilot genome-wide association study (GWAS) in an Indian CKD population, published in the International Journal of Nephrology.
​
pubmed.ncbi.nlm.nih.gov/41322097/

#CKD #Nephrology #GWAS #Genomics

2/7
In a #GWAS of >150,000 Omicron cases across four cohorts, we identify 13 genome-wide significant loci, with 8 novel infection-risk signals compared to earlier COVID-19 waves.
@finngen.bsky.social @estbiobank.bsky.social
@massgeneralbrigham.bsky.social
@ssi-dk.bsky.social @bfeenstra.bsky.social

Biological insights into schizophrenia from ancestrally diverse populations - Nature Genome-wide association studies incorporating data for populations of African ancestry provide an expanded view of the genetic basis of schizophrenia, which has previously been studied mainly in Europ...

Great to see this work being done. I hope we see much more of it in other disease areas.

#schizophrenia #GWAS #diversity

www.nature.com/articles/s41...

Really honored that our kidney volume genetics paper is accompanied by an editorial commentary in the Feb issue of @kidneyint.bsky.social. Many thanks to @cpattaro.bsky.social & Belen Ponte for the thoughtful perspective, and to all collaborators who made this work possible
#CKD #DeepLearning #GWAS

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function Chronic kidney disease (CKD) is defined as sustained abnormalities in kidney function or structure. Genetic studies of CKD have largely focused on kidney function markers such as estimated glomerular ...

The commentary introduces the beautiful paper by 👏 @s-monteiromartins.bsky.social @olegborisovphd.bsky.social & the @sfb1453.bsky.social group that present results of #GWAS of kidney volumes estimated through convolutional neural networks #CNN
www.kidney-international.org/article/S008...

#GWAS & #Multiomics reveals a complex bidirectional causality between #Diabetes & #Iridocyclitis, revealing complex bidirectional causality, with insights into shared molecular mechanisms and preventive clinical strategies.

#OpenAccess: doi.org/10.1016/j.ge...

Registrations are still open for the GWAS course starting on Jan 26th!

If you are interested, check it out: www.physalia-courses.org/courses-work...

#GWAS #Bioinformatics #Genomics