#EveryOrganIsAnImmuneOrgan

I cannot be more agree. #EveryOrganIsAnImmuneOrgan Macrophages play a pivotal role both in health and dissease. In this study we demonstrated some hypothesis previously rised about the feedback of I1b in atrial tissue and the participation of resident macrophages in the signaling that leads to AF.

IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression - Nature Cardiovascular Research Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various ris...

#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective.
#ScienceSavesLives

Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk Van der Stede et al. identified a role for mononuclear cells in the skeletal muscle microenvironment to steer the response to exercise. Mast cells locally secrete histamine during exercise, triggering...

#WeekendRead. #EveryOrganIsAnImmuneOrgan. @wimderave.bsky.social &co show @cp-cellmetabolism.bsky.social that mast cells release histamine during skeletal muscle exercise which acts on other immune cells, driving an inflammatory program that favors muscle glycogen resynthesis! #LoveScience

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature IL-33 induces tertiary lymphoid structures.

#WeekendRead! #EveryOrganIsAnImmuneOrgan 😉! The Balachandran lab &co show @ Nature that the alarmin domain of IL33 expands lymphoneogenic ILC2s which favor tertiary lymphoid organ formation in colitis & during tumor growth! Engineered IL33 can be an antitumoral! www.nature.com/articles/s41...