Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation Microscopy and genomics are used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. Here, we describe expansion i...

@science.org Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation | Science www.science.org/doi/10.1126/...
@jbuenrostro.bsky.social @eboyden3.bsky.social + al @broadinstitute.org @harvard.edu
#ExIGS #Chromatin #Lamin #Progeria #Aging #ExpansionMicroscopy

#ExIGS: Combining #expansion #microscopy (#ExM) & in situ #genome #sequencing (#IGS) enables sequencing of #genomic #DNA & #superresolution localization of #nuclear #proteins in single #cells:

Preprint: doi.org/10.1101/2024...
#DIYbio #lab #instruments #NGS #fluorescence #imaging