TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...

Please check out our latest publication showing that activated #muscle stem cells depend on a niche-restricted, autoregulatory #fibronectin splice variant that is strongly affected by #aging.

🔗 www.nature.com/articles/s41...

#StemCells #SkeletalMuscle #MuSCs #ExtracellularMatrix #Splicing

Xingchen Li, Christoph Ballestrem, et al. @mcrcellmatrix.bsky.social show that multidomain interactions between talin and tensin3 regulate #integrin activity, fibrillar #adhesion formation, #fibronectin assembly, and mechanosensitive tensin3 phase separation. rupress.org/jcb/article/...

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

#ECM deposition is also a key feature of niche priming. We found that deposition of #fibronectin in the metastatic lung was reduced in the absence of #UPP1 & that #uracil (derived from UPP1-expressing neutrophils) can directly influence the ECM deposited by #fibroblasts (8/14)

What a great week at the #Fibronectin, #Integrins & related molecules #GRC. Inspiring and interesting talks, and the opportunity to speak to so many amazing people in the field. Really hope to be able to join you all again in 2027

What a view for science! ☀️⛰️
#GRC on #Fibronectin, #Integrins and Related Molecules is going strong in Renaissance Tuscany Il Ciocco with a beautiful backdrop. I am happy to share my work on focal adhesion mechanics in my first-time Gordon conference with the brightest minds in the field. 🔬

Go to the #GRS stay for the #GRC. some of my favourite discussions have happened at this meeting, I dunno if I can go but I highly encourage anyone interested in #fibronectin #integrins and all #RelatedMolecules, go see cool science, chat to great scientists and all in a not to shabby region of 🇮🇹

www.independent.co.uk/news/science...

#fibronectin
#APOEe4 gene
#Alzheimers

Real-time visualization of bacterial-vascular interactions in blood vessels of live mice reveals distinct interaction properties mediated by #fibronectin and GAG-binding sequences of the bacterial vascular adhesin BBK32. ...

#Bacteria recruit & polymerize plasma #fibronectin to stabilize interactions with endothelial cells lining blood vessels under vascular shear stress.

http://www.pnas.org/content/early/2017/04/05/1615007114

Real-time visualization of bacterial-vascular interactions in blood vessels of live mice reveals distinct interaction properties mediated by #fibronectin and GAG-binding sequences of the bacterial vascular adhesin BBK32. ...

Plasma #fibronectin -stabilized catch bonds mediate bacterial-endothelial interactions under vascular shear stress.

http://www.pnas.org/content/early/2017/04/05/1615007114

Vascular Interactions of #Lymedisease #bacteria in a Living Host Mediated by #fibronectin #glycosaminoglycans and the vascular adhesin BBK32

http://dx.plos.org/10.1371/journal.ppat.1000169

Real-time visualization of bacterial-vascular interactions in blood vessels of live mice reveals distinct interaction properties mediated by #fibronectin and GAG-binding sequences of the bacterial vascular adhesin BBK32. ...

Real-time visualization of bacterial-vascular interactions in blood vessels of live mice reveals distinct interaction properties mediated by #fibronectin and GAG-binding sequences of the bacterial vascular adhesin BBK32. ...

Intravital microscopy visualization of bacterial-vascular interactions in blood vessels reveals distinct interaction properties mediated by #fibronectin and GAG-binding sequences of bacterial vascular adhesin BBK32. ...

#Bacteria recruit & polymerize plasma #fibronectin to stabilize interactions with endothelial cells lining blood vessels under vascular shear stress.

http://www.pnas.org/content/early/2017/04/05/1615007114

#Bacteria recruit & polymerize plasma #fibronectin to stabilize interactions with endothelial cells lining blood vessels under vascular shear stress.

http://www.pnas.org/content/early/2017/04/05/1615007114

Molecular Mechanisms Involved in Vascular Interactions of... Author Summary Many bacterial pathogens can cause systemi...

#Fibronectin, #Glycosaminoglycan and BBK32-dependent Bacterial-Vascular Interactions in a Living Host.

http://dx.plos.org/10.1371/journal.ppat.1000169

Plasma #fibronectin stabilizes bacterial–endothelial interactions under vascular shear stress by a catch-bond mechanism.

http://www.pnas.org/content/early/2017/04/05/1615007114

Plasma #fibronectin stabilizes bacterial–endothelial interactions under vascular shear stress by a catch-bond mechanism.

http://www.pnas.org/content/early/2017/04/05/1615007114

Our recent OA paper describing how the #LymeDisease pathogen recruits plasma #fibronectin to interact with blood vessels

Plasma fibronectin stabilizes Borrelia burgdorferi–endothelial interactions under vascular shear stress by a catch-bond...