Figure 1 displays adjusted odds ratios (ORs) and probabilities for seizure response at 6 months. Graph A shows ORs comparing antiseizure meds; graph B shows model-adjusted probabilities for each medication: Cenobamate, Lacosamide, Perampanel, Brivaracetam.

In adults with drug-resistant #FocalEpilepsy, cenobamate was associated with greater seizure reduction and seizure freedom vs brivaracetam, lacosamide, and perampanel, but with more adverse effects.

ja.ma/3ZE7zAN

Figure 1 shows adjusted odds ratios(ORs) and probabilities of 50% or greater response and greater than or equal to 3-month seizure freedom at 6-month follow-up. Graph A displays adjusted ORs in comparisons of antiseizure medications.

In adults with drug-resistant #FocalEpilepsy, cenobamate was associated with greater seizure reduction and seizure freedom vs brivaracetam, lacosamide, and perampanel, but with more adverse effects.

bit.ly/4qIo6il

Sophie Adler, Michael-Preisträgerin 2025 erklärt, welchen Beitrag ihre Forschung zur medizinischen Versorgung von Menschen mit Epilepsie leistet.
#allgemeinegesundheitsversorgung #stiftungmichael #epilepsietherapie #epilepsy #brain #epilepsie #focalepilepsy #healthcoverage #LoveUCL

This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel

A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures.

We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory

What to Know About Focal Epilepsy — Verywell Focal epilepsy is when people have recurrent seizures that may cause symptoms affecting only one side of the body. Seizures in epilepsy can be focal or generalized.

"Focal epilepsy seizures can begin at any age—from infancy to adulthood—and usually are controlled with medication or other interventions."

#Epilepsy #Seizures #FocalSeizures #FocalEpilepsy
#EpilepsyAwarenessMonth

apple.news/AOltSv8cwRd-...

A multivariate measure for mapping deviations in brain microstructure was developed to characterize limbic pathology in patients with temporal lobe epilepsy.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #diffusionMRI #drugresistant #focalepilepsy #MRI #NODDI #normativemodeling

We report the impact of climatic variables on hyponatremia-related hospitalizations in a well-phenotyped cohort of people with focal #epilepsy exposed to #carbamazepine or its derivatives.
doi.org/10.1111/epi....

#epilepsia #ILAE #antiseizuremedication #climatechange #focalepilepsy #hyponatremia

The CSMD genes are associated with epilepsies: CSMD2 with focal epilepsy/FCD and CSMD3 with a phenotype spectrum including focal epilepsy, febrile seizures, and DEE.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #CSMD2 #CSMD3 #febrileseizures #focalepilepsy #infantilespasms

Key point: We scanned 31 patients with parallel transmit and conventional 7T magnetic resonance imaging (MRI), finding previously-unreported structural lesions in nine patients (29% of cases).
doi.org/10.1111/epi.... Open Access

#epilepsy #ilae #epilepsia #7TMRI #epilepsysurgery #focalepilepsy

Key point: Several newer antiseizure medications, including the most recent, cenobamate, are now available for the treatment of focal epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #Cenobamate #SKlifescience #antiseizuremedications #drugresistantepilepsy #focalepilepsy

Key point: Seizure freedom has been a goal of epilepsy treatment for >25 years, but rates of seizure freedom have changed little during this time.
doi.org/10.1111/epi....

#epilepsy #ILAE # Cenobamate #SKlifescience #focalepilepsy #seizurefreedom

Sleep-related hypermotor epilepsy—No longer controversial
doi.org/10.1111/epi....

#epilepsy #ilae #SHE #focalepilepsy #hypermotorseizures #sleep #parasomnias

Key point: As memory dysfunction is common in people with temporal lobe epilepsy, we explored spindle–slow wave coupling in this patient group compared to healthy controls.
doi.org/10.1111/epi....

#epilepsy #ILAE #cognition #coupling #focalepilepsy #highdensityEEG #sleep

Key point: We calculated polygenic risk scores for genetic generalized epilepsy and for focal epilepsy in individuals from 257 multiplex epilepsy families.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #familialepilepsy #focalepilepsy #geneticgeneralizedepilepsy #polygenicriskscores

Key point: A low dose of antiseizure medications may be started in adults with a new diagnosis of focal epilepsy of unknown etiology and low seizure frequency.
doi.org/10.1002/epi4...

#epilepsy #ILAE #efficacy #focalepilepsy #lowdose #monotherapy #newlydiagnosedepilepsy #randomizedtrial

Key point: The study analyzed the prescribing behaviors of epileptologists and their consequences in WOCP already using VPA during 2014–2019.
doi.org/10.1111/epi....

#epilepsy #ILAE #focalepilepsy #tonicclonicseizures #Valproate

Key point: LEV is the best choice when combined with antiepileptic clinical guidelines on the basis of its efficacy in decreasing seizure frequency.
doi.org/10.1111/epi....

#epilepsy #ILAE #antiseizuremedication #costeffectiveness #lacosamide #monotherapy #focalepilepsy