Graphic abstract

#Medsky🧪 #oncosky #pharmasky #publichealth #Immunecheckpointinhibitors improve cancer survival but can trigger immune related adverse events. Among these, #fulminantmyocarditis is an often fatal complication with limited therapies. This study makes a very important discovery

This review summarizes the molecular mechanisms and key #signalingpathways driving #CytokineStorm, highlights its role in severe inflammatory diseases like #FulminantMyocarditis, #ARDS, HLH, and CRS, and discusses emerging therapeutic strategies.

#STTT: doi.org/10.1038/s413...

Single-nucleus and #SpatialTranscriptomics reveal how #mesothelial and immune cell interactions drive #CVB3-induced #FulminantMyocarditis, identifying the IFN-γ/Spi1 axis as a key therapeutic target and demonstrating IVIG’s efficacy.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Spatiotemporal transcriptomic analysis of coxsackievirus B3 (CVB3)-induced #FulminantMyocarditis (FM) in A/J mice provides insights into the #pathogenesis of FM and highlights actionable #TherapeuticTargets. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...