Clinical characteristics and host factors associated with drug-induced liver injury in 264 pulmonary tuberculosis patients from Hainan province, China

Molecular diagnostics cut #Tuberculosis diagnosis time in Hainan, while male sex and older age were linked to stronger #inflammation and higher #hepatotoxicity risk, underscoring the need for rapid testing and personalized monitoring in TB care.
#OpenAccess: doi.org/10.1016/j.dc...

Toxicological effects of green tea catechin extract on rat liver: Delineating safe and harmful doses

This Open Chemistry study analysed the #Phytochemistry of #GreenTea #Catechin extract, and its influence on biochemical parameters, #Antioxidant status, & histological aberrations in rat liver, revealing that high doses of GTCE induce #Hepatotoxicity.
#OpenAccess: doi.org/10.1515/chem...

Meet Peter & Teresa this week at the #GRC on Cellular & Molecular Mechanisms of Toxicity in Andover! 🎤Today 10:55AM – Peter presents our immunocompetent #OrganOnChip models for #SafetyAssessment 📊Today & tomorrow 4–6PM – Teresa showcases the #LiverChip for #OpticalSensing in #Hepatotoxicity studies.

Takeaway #1: The Liver-Chip S1 demonstrated differential toxicity profiles of four cannabinoids that traditional animal models could not clearly distinguish.

Takeaway #2: The Liver-Chip S1 identified parenchymal cell-specific mechanisms of cannabinoid toxicity--effects that would have been missed by standard monoculture assays.

Takeaway #3: The Liver-Chip S1 revealed early inflammatory and functional markers of cannabinoid toxicity, offering insight into potential mechanisms and early warning signs.

Takeaway #4: The Liver-Chip S1 modeled dose- and compound-specific hepatotoxicity using clinically relevant exposures of cannabinoids.

🧪 We’re excited to share the results of a recent collaboration with @herbalifeglobal.bsky.social, now published in Science Reports!

Using Emulate’s #organonchip Quad-Culture Liver-Chip S1, this study explored the #hepatotoxicity potential of four common #cannabinoids — CBD, CBG, CBN, and CBC.

In a study published April 29, 2025, in Environmental Science and Ecotechnology, researchers detailed how tire-derived compounds interfere with liver and neurological functions in zebrafish.
#Hepatotoxicity #zebrafish
Details: doi.org/10.1016/j.ese.2025.100567

Amoxicillin-Clavulanate: Risks of Drug-Induced Liver Injury Clinical and Research Insights on Drug-Induced Liver Injury from Amoxicillin-Clavulanate Amoxicillin and clavulanate, a powerful combination of antibiotics, hold a vital place in modern medicine, especially for the treatment of mild to moderate bacterial infections. Commonly prescribed for conditions such as sinusitis, bronchitis, otitis media, cellulitis, and community-acquired pneumonia, this duo represents one of the most frequently utilized antibiotic regimens today.

Amoxicillin-Clavulanate: Risks of Drug-Induced Liver Injury - #ClinicalResearch #LiverHealth #Amoxicillin #Clavulanate #Antibiotics #DrugInducedLiverInjury #PatientSafety #HealthcareAwareness #Hepatotoxicity #Pharmacology #AntibioticResistance #MedicalEducation #PatientCare #PublicHealth

Hepatitis asociada al uso de tirzepatida (agonista GLP1) para pérdida de peso en mujer de 30 años; causalidad probable; mecanismo desconocido

tinyurl.com/284kowaa @annalsofim.bsky.social

#Farmacovigilancia #RAM #Hepatotoxicidad #RAM #Pharmacovigilance #AdverseDrugReaction #Hepatotoxicity #ADR

Welcome! You are invited to join a meeting: Using human biomimetic liver microphysiology system and quantitative systems toxicology models to study MASLD and DILI . After registering, you will receive... Join us for two insightful presentations on using human biomimetic liver microphysiology system and quantitative systems toxicology models to study MASLD and DILI. The first presentation, led by Lawr...

Join us this Thursday Jan 9th 11am EST/8amPST
@aasld-heptoxsig.bsky.social #Hepatotoxicity seminar " Using human biomimetic liver microphysiology system & quantitative systems toxicology models to study MASLD & DILI" presented by Drs. Vernetti & Miedel register 👇 aasld.zoom.us/meeting/regi...