Scientists developed Cp1 that uniquely blocks C5a–C5aR1 interactions, showing superior plasma stability, potent suppression of #hyperinflammation, improved pathogen clearance, and extended survival in #sepsis models. @fudan-university.bsky.social

#STTT: doi.org/10.1038/s413...

- #CytokineStorm & #Hyperinflammation: Neutrophils are implicated in the cytokine storm observed in severe viral infections, contributing to the release of proinflammatory cytokines & chemokines that exacerbate tissue injury.

Purine nucleoside phosphorylase (#PNP), upon activation by viral PB1-F2, acts as a #HubGene regulating viral replication and #Hyperinflammation via #PurineSalvage, highlighting PNP as a potential #AntiInfluenza target.

#STTT #OpenAccess: doi.org/10.1038/s413...

A novel long-acting C5a-blocking cyclic peptide blocks the C5a–C5aR1 interaction to suppress #Hyperinflammation & maintain #ImmuneHomeostasis while reducing #Sepsis-induced innate immune & organ dysfunction. @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

🚨 It is time for another Infection Case Round!

Join us tomorrow, 4th June at 17:30, for a fantastic session hosted by our colleagues at St George’s.

This round’s focus: #Hyperinflammation!

Don't miss what promises to be a rich and insightful discussion!
#BPAIIGCaseRounds