Frontiers | MYC at the tumor–immune interface: mechanisms of immune escape and immunotherapy resistance Immunotherapies have transformed cancer treatment by harnessing the immune system to recognize and eliminate malignant cells, offering durable clinical benef...

New review just out in Frontiers in Immunology! 🎉

We dive into how #MYC reshapes the tumor–immune interface to drive #immuneescape and resistance to #immunotherapy.
Open access here 👉 www.frontiersin.org/journals/imm...
@vhio.bsky.social @icreacommunity.bsky.social #peptomyc

Frontiers | MYC at the tumor–immune interface: mechanisms of immune escape and immunotherapy resistance Immunotherapies have transformed cancer treatment by harnessing the immune system to recognize and eliminate malignant cells, offering durable clinical benef...

New review just out in Frontiers in Immunology! 🎉

We dive into how #MYC reshapes the tumor–immune interface to drive #immuneescape and resistance to #immunotherapy.
Open access here 👉 www.frontiersin.org/journals/imm...
@vhio.bsky.social @icreacommunity.bsky.social @lsouceklab.bsky.social #peptomyc

to mitigate the emergence of new variants & ensure effective long term epidemic control .
Viral traits & socio-economic context jointly shaped #SARSCoV2 variant fitness. #Immuneescape was more influential for lineage growth in low-resource settings,

Scientists uncover how SARS-CoV-2 variants outsmart the immune system – BioNews Central Researchers analyzed over a thousand 3D structures of antibodies bound to the SARS-CoV-2 spike protein, creating a structural atlas that reveals how the immune system targets the virus and how SARS-CoV-2 evolves to evade it. ...

Researchers analyzed over a thousand 3D structures of #antibodies bound to the #SARSCoV2 #SpikeProtein, creating a structural atlas that reveals how the #ImmuneSystem targets the #virus and how SARS-CoV-2 evolves to evade it.
#COVID19 #ViralMutations #SARSCoV2Variants #ImmuneEscape 

Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, espec...

Age and viral evolution reduce CD4⁺ T cell reactivity to the conserved iCope epitope, while humoral cross reactivity remains mutation sensitive only. 
#ImmuneEscape #TCellImmunity #PanCoronavirus

👤EVBC: Andreas Nitsche
📄

Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer!

First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape.

t.co/1YUzihcY2H

#nonanimal #alternative #methods #cancer #immunotherapy

Immune escape of Omicron lineages BA.1, BA.2, BA.5.1, BQ.1, XBB.1.5, EG.5.1 and JN.1.1 after vaccination, infection and hybrid immunity bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Immune escape of Omicron lineages BA.1, BA.2, BA.5.1, BQ.1, XBB.1.5, EG.5.1 and JN.1.1 after vaccination, infection and hybrid immunity | bioRxiv
www.biorxiv.org/content/10.1...

#Covid #ImmuneEscape

OP: twitter.com/EckerleIsabe...