Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling?

A PEARL w/ @astar-idlabs.bsky.social PhD student Xiangyu Sui #IDsky #microsky #immunsky "Animal models of Mycobacterium abscessus pulmonary infection phenotypes: What are we modeling?" We propose Mabs infection is more than one disease and requires more than one model 1/3
doi.org/10.1371/jour...

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage Author summary Mammalian infection with schistosome worms results in the deposition of parasite eggs in the liver, where they secrete organ damaging toxins. In response, the liver generates a cellular...

Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪

dx.plos.org/10.1371/jour...

#PsychSciSky #ImmunSky #Immunology #Psychiatry

Sustained IFN Signature Suppression with Anifrolumab in a SAVI patient Refractory to JAK Inhibitor and Dazukibart Therapy Objective To report the efficacy and safety of interferon-β (IFNβ) neutralizing monoclonal antibody (dazukibart), followed by treatment with anti-IFNAR1 antibody (anifrolumab), in a patient with STI...

In Arthritis & Rheumatology
acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...
#Medsky #Immunsky

Trends in human parainfluenza virus in Scotland before and after the peak of the COVID-19 pandemic, January 2017 to October 2023 Background Human parainfluenza viruses (HPIV) commonly cause upper respiratory tract infections, with potential for severe lower respiratory complications. Understanding seasonal increases informs str...

#Medsky🧪 #idsky #pedsky #immunsky #episky #publichealth
@cdc Clinical Overview of #HumanParainfluenzaViruses (HPIVs)
www.cdc.gov/parainfluenz...
The Impact of HPIVs on Child Health: A Clinical
Study
dergipark.org.tr/en/download/...

www.eurosurveillance.org/content/10.2...

HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling Diverse viruses ensure their replication by blocking the activation of NF-κB signaling by STING.

#MedSky🧪#idsky #Immunsky #publichealth How do viruses disarm cellular antiviral responses?
Examining a range of both DNA & RNA 🦠 incl HIV-1 & #SARSCoV2 The study find they support replication by suppressing the STING pathway & preventing it from activating NF-kB.

www.science.org/doi/10.1126/...

#MedSky🧪 #IDSky #Immunsky #neurosky Ubiquitination as the major route for targeting proteins for degradation by the 26S proteasome but ubiquitin also serves non-degradative roles in many cellular processes incl cell signalling, chromatin regulation, & protein trafficking in #Neurologicaldisorders

Welcome! You are invited to join a meeting: Prevention of respiratory virus transmission by resident memory CD8+ T cells. After registering, you will receive a confirmation email about joining the me... The ATS Journal club sponsored by the Assembly on Allergy, Immunology, and Inflammation (AII) will feature the article: “Prevention of respiratory virus transmission by resident memory CD8+ T cells” ...

@ats-rcmb.bsky.social #Lungsky #IDsky #Immunsky Excited to be participating in ATS journal club this Thursday -"Prevention of Respiratory Virus Transmission by Resident Memory CD8+ T Cells." thoracic.zoom.us/meeting/regi...

Several factors modulate Long Covid progression. Increased acute disease severity, elevated BMI, female sex, and concomitant comorbidities increase the risk of Long Covid, whereas vaccination before infection decreases the risk. Treatments in the acute phase and age may also influence risk.CREDIT: A. MASTIN/SCIENCE TRANSLATIONAL MEDICINE

#MedSky🧪 #IDsky #immunsky #SkyRx #pharmaSky Translating insights into #Drugdevelopment for #LongCovid & Risk factors Factors modulating the development of LC/ #NeuroCovid
🦠 Persistent viral reservoirs
🦠Dysregulated immune responses
🦠 Autoimmunity
🦠 Inflammation & plasma inflammatory biomarkers

Hi everyone! I'm an immunologist interested in lung diseases, a cyclist, a railfan, and a photographer of space and weather events.

Starter packs
Immunology #Immunsky: bsky.app/starter-pack...

Meteorologists/Weather #Wx bsky.app/profile/ianl...

Bicycling/Urban transit bsky.app/starter-pack...

Second Postdoc position now live, closing date 29th September. This one is more for the sequencing/omics- interested and driven! #ImmunSky #Immunology #helminths

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...