eggs can embolize to other organs or become entrapped in tissues while en route to bladder or intestine
-Once deposited, eggs secrete proteolytic enzymes➡️granulomatous reactions&fibrosis in tissues➡️portal/pulmonary HTN. host immune response to #schistosome eggs➡️clinical dz
Delighted to share our paper on the role of SOX9 in liver #fibrosis and #granuloma formation during #schistosome infection - a really great collaboration over the past few years with the Piper Hanley lab! #ImmunSky 🪱🧪
dx.plos.org/10.1371/jour...
Our 2025 January issue bit.ly/2N9R8Es reviews #type2 #immunity in #gut #homeostasis & #Plasmodium transmission, #malaria elimination in Thailand, male & female #schistosome interactions, #placental malaria & #circumsporozoite protein-specific immunity, #community #ecology of #invasive #ticks, & more
Distribution of the #schistosome intermediate #snail host #Biomphalaria pfeifferi in East #Africa's river systems and the p…... published in Transactions of The Royal Society of Tropical Medicine and Hygiene using @gbif.org mediated data:
#CiteTheDOI: ❌
https://doi.org/10.1093/trstmh/trae115
Last chance to apply for this unique competition-funded NERC GW4+ PhD - joint with Natural History Museum of London www.exeter.ac.uk/study/fundin... (entry sept 2025)!!
Interdisciplinary project hosted @lsiexeter.bsky.social
#cilia #parasite #snails #biophysics #schistosome
Population genetic structure of Schistosoma bovis and S. curassoni collected from cattle in Mali Abstract Schistosomiasis is of medical and veterinary importance. Despite the critical situation of schistosomiasis in sub-Saharan Africa, few molecular epidemiological studies have been carried out to determine the role of animals in its transmission. In Mali, it has been over three decades since the last molecular study of animal schistosomes was carried out. It is now urgent to identify circulating strains of the parasite because of potential interactions with other schistosome species, which could complicate disease control. The aim of our work was to study the composition and genetic structure of schistosome populations collected from cattle. The prevalence of schistosome was 23.9%, with the prevalences of Schistosoma bovis (Sb) and S. curassoni (Sc) estimated at 12.6% and 9.8%, respectively. No hybrid strains or S. haematobium were found. The parasites displayed distinct geographical distribution with Sb dominant in Bamako (78.8% and 98% in Central Bamako Slaughterhouse and Sabalibougou Slaughterhouses, respectively) and Sc dominant in Kayes (95.3%). Of the 476 parasites with a complete genetic profile, 60.4% were pure Sc, and were mainly from Kayes. We identified two clusters at the site level (Fst of 0.057 and 0.042 for Sb and Sc, respectively). Cluster 1 was predominantly composed of pure Sb parasites and cluster 2 was mainly composed of pure Sc parasites, from Bamako and Kayes, respectively. Our study shows that cattle schistosomiasis remains endemic in Mali with S. bovis and S. curassoni. A robust genetic structure between the different schistosome populations was identified, which included two clusters based on the geographical distribution of the parasites. Figure: Principal component analysis (PCA) of schistosome worm parasite recovered from three slaughterhouses in Mali.
Illustration image: Schistosoma mansoni. SEM photograph from Wikimedia, public domain.
Schistosomiasis is of medical and veterinary importance.
In this paper, #schistosome populations collected from cattle in Mali were studied. Schistosoma bovis and S. curassoni were collected; no hybrid strains or S. haematobium were found. 🧪
doi.org/10.1051/para...
Prospective PhD students...
Please check out this exciting opportunity in Prof. Matt Berriman's lab in Glasgow to investigate how #schistosome eggs interact with tissues of their host to cause #granulomas, co-supervised by yours truly 😊 🪱 🧪 #ImmunoSky
www.gla.ac.uk/postgraduate...
Time for an #introduction!
I'm a Staff Scientist at #TxBiomed working on:
• #schistosome blood fluke (drug resistance, host specificity, etc.) using #genetics and #genomics
• #microbiome 🦠 of snail 🐌 vectors of schistosomes
I do #bioinformatics 💻 using #bash, #R, and #python.
See y'all around!
On my way to @uofglasgow.bsky.social to visit the School of #Infection and #Immunity and talk about our work on #mucosal responses during #schistosome infection - looking forward to it! #ImmunoSky 🪱 🧪
A lemon and blackberry sponge cake, decorated with a fondant dendritic cell, snail, mouse and graphene.
A slice of lemon and blackberry sponge cake, with a fondant snail.
Leaving drinks @lydiabeckeriii.bsky.social today - so many great friends and colleagues that I’ll miss massively! But I’ve made them all promise to come visit in Edinburgh. And check the #cake, complete with #dendritic cell, #graphene, #schistosome infected snail & lab mouse, made by Helen Parker!
I'm looking for 2 Postdocs & a Technician to join my team in Edinburgh, investigating #mucosal #immunity & #inflammation during #schistosome #infection. If this sounds exciting to you, pls apply! (by 19th Sep)🪱🔬🏴
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
If you're looking for a PhD, & passionate about #helminths & #mucosal #immunity, please apply! This project in Edinburgh will investigate intestinal/lung #inflammation, tissue damage & repair during murine #schistosome infection (deadline 10th August) 🪱🤓 www.findaphd.com/phds/project...
