Hitoshi Uchida @urochestersmd.bsky.social & colleagues found that Ascl3+ #ionocytes in murine #salivary gland ducts are innervated sensory cells that display unique calcium signalling characteristics & contribute to the composition of saliva 🔎 🔬
🔗 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Immunofluorescence confocal micrographs (IF) from control (ctrl.) and foxi1 morphants (foxi1 MO; 3 or 0.5 pmol) at st. 32 stained for Acetylated-α-tubulin (Ac.-α-tub., cilia, gray), F-actin (Actin, cell borders and morphology, gray). Targeted cells were identified by membrane RFP expression (memRFP, magenta) and are outlined in blue. Strongly targeted areas targeted by 3 pmol of foxi1 MO fail to generate intercalating cell types. Location of insets is indicated by dashed yellow box in upper panels.
The TF Foxi1 regulates #ionocytes and is associated with several human diseases. @walenteklab.bsky.social &co show that low concentrations of Foxi1 in progenitor cells maintain #epidermal identity via the #NotchPathway, affecting #mucociliary cell fates in Xenopus @plosbiology.org 🧪 plos.io/3YLOhcp
Immunofluorescence confocal micrographs (IF) from control (ctrl.) and foxi1 morphants (foxi1 MO; 3 or 0.5 pmol) at st. 32 stained for Acetylated-α-tubulin (Ac.-α-tub., cilia, gray), F-actin (Actin, cell borders and morphology, gray). Targeted cells were identified by membrane RFP expression (memRFP, magenta) and are outlined in blue. Strongly targeted areas targeted by 3 pmol of foxi1 MO fail to generate intercalating cell types. Location of insets is indicated by dashed yellow box in upper panels.
The TF Foxi1 regulates #ionocytes and is associated with several human diseases. @walenteklab.bsky.social &co show that low concentrations of Foxi1 in progenitor cells maintain #epidermal identity via the #NotchPathway, affecting #mucociliary cell fates in Xenopus @plosbiology.org 🧪 plos.io/3YLOhcp
Immunofluorescence confocal micrographs (IF) from control (ctrl.) and foxi1 morphants (foxi1 MO; 3 or 0.5 pmol) at st. 32 stained for Acetylated-α-tubulin (Ac.-α-tub., cilia, gray), F-actin (Actin, cell borders and morphology, gray). Targeted cells were identified by membrane RFP expression (memRFP, magenta) and are outlined in blue. Strongly targeted areas targeted by 3 pmol of foxi1 MO fail to generate intercalating cell types. Location of insets is indicated by dashed yellow box in upper panels.
The TF Foxi1 regulates #ionocytes and is associated with several human diseases. @walenteklab.bsky.social &co show that low concentrations of Foxi1 in progenitor cells maintain #epidermal identity via the #NotchPathway, affecting #mucociliary cell fates in Xenopus @plosbiology.org 🧪 plos.io/3YLOhcp
Recent publications from DRN members, Aug–Sept 2025
#Heterochromatin, #Drosophila #olfaction, #pluripotency extinction, #anatomy #education, #zebrafish olfactory #ionocytes, #hearing loss, #machine #learning and more!
See thread for details ⬇️
#Ionocytes are another rare basal derivative and we find their signatures in sclc.
Prior work shows adenoa go thru a basal-like state on their way to NE.
Our new single cell lineage tracing in organoid models support basal plasticity to all of these states.
Finally, early stage SCLC
