Leukocyte stalling in 🐭Retinal microvasculature
2PM

In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls

87% stalls occur at vessel junctions, where 71% occupied with #Pericyte

⏫RBC flow irregularity

#JCBFM 2025
journals.sagepub.com/doi/10.1177/...

"Plug"
Microglia (~20%) physically contract with #EndothelialCell & #Pericyte through gaps b/w adjacent #Astrocyte endfeet

A meticulous analysis of #MICrONS volumetric EM data
1 mm3 🐭visual cortex🤩

@gazz4science.bsky.social @sorengrubb.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...

2DG CESL MRI in rat brain after stroke.

🔬🧪🧠⚡ I am extremely happy to announce that our paper on imaging #brain glucose #metabolism using metabolic #MRI in a 🐀 rat model of ischemic stroke is now published in #JCBFM (journals.sagepub.com/doi/10.1177/...). #OpenAccess #OpenData Check the🧵 🤓 #NeuroSky ⏬⏬

Our very own Dr Clare Howarth from @sheffielduni.bsky.social speaking at a satellite meeting on day 1.. alongside Ravi Rungta, Anna Devor, Andy Shih, Barbara Linde, Mohamad El Amki - what a session!

Thanks to @blacoste.bsky.social for the photos!

#science #JCBFM #neuroscience #glia #brainbloodflow

Association between cerebral oxygenation and usual parameters of cerebral perfusion in critically ill patients with acute brain injury In patients with acute brain injury (ABI), optimizing cerebral perfusion parameters relies on multimodal monitoring. This include data from systemic monitoring–mean arterial pressure (MAP), arterial c...

A good start to the year with the publication of this work in #JCBFM

pmc.ncbi.nlm.nih.gov/articles/PMC...

#neurocrit

Inhibition of Na+/K+ ATPase-mediated Src activation with pNaKtide in🐭 #Migraine Atp1a2 G301R/+
⏫🧠arteriolar diameter
⏬🧠 hypoperfusion
⏫#NeuroVascularCoupling

Look at this mind-blowing #LaserSpeckleImaging of🐭🧠microvasculature🤩

@chrstaehr.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...

I am very excited to share our new paper in #JCBFM (journals.sagepub.com/doi/10.1177/...)! We show that targeting Na,K-ATPase-dependent #Src kinase activation can prevent cerebral hypoperfusion and ⬆️ (video) #neurovascular coupling in a 🐭model of familial hemiplegic #migraine.

Here is a summary 🧵

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

Defining Brain #Pericyte Nomenclature, Must-read🤓

Similar A-C-V hierarchy of pericytes in other organs?😁

Dr. Andy Shih Lab #JCBFM 2017
journals.sagepub.com/doi/10.1177/...