Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia AbstractPersistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malignan...

JMML stem cells aren’t epigenetically “stuck” in a fetal state.

They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...

#JMML #epigenetics #hematology #cancer

Very happy and proud to see this story finally published! 🎉🥳
#epigenetics #hematology #jmml #leukemia

On the Verge to Malignancy: Cytopenia and Beyond - Ewog Symposium On the Verge to Malignancy: Cytopenia and Beyond International Symposium on bone marrow failure, predisposition, MDS and MPD in the Young Dear colleagues and friends, we are pleased to wel...

Great to meet friends and colleagues at this year’s EWOG-MDS meeting in Berlin. We had great discussions and developed new project ideas and collaborations with the aim of improving risk stratification and patient care for JMML patients.
#jmml #ewogmds #precisionmedicine www.ewogberlin2025.org

Absolutely outstanding presentation by @ellouka.bsky.social at #ASH24 about the role of dendritic cells secreting GAS6 in maintaining LSCs in juvenile myelomonocytic leukemia #jmml #HemeSky

A big thank you to Elliot for organizing this great meeting every year at #ASH! It’s always fun to be there and lots of interesting talks. #JMML #HemeSky

Oncofetal reprogramming in #JMML
Maybe also of interest to the folks on #EpiSci!