What are the different types of Targeted Therapies?

Now presenting Dr. Sonam Puri.

#LungCancer #TargetedTherapies #KinaseInhibitors #BispecificAntibodies

Design, Synthesis, and Structure–Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors @acs.org pubs.acs.org/doi/10.1021/...

#KellyChibale #CancerResearch #Leukaemia #TargetedTherapy #KinaseInhibitors #MedicinalChemistry #DrugDiscovery

Nanotechnology revolutionizing osteosarcoma treatment: Advances in targeted kinase inhibitors Osteosarcoma (OS) is the most frequent primary malignant bone tumor in adolescents and young adults. Despite the advances in therapy, OS remains an ominous problem because of its high metastatic…

This review highlights how #nanotechnology enhances the delivery and efficacy of #kinaseinhibitors in #Osteosarcoma, tackling challenges like #DrugResistance and paving the way for safer, more effective, and personalized therapies.

#OpenAccess in Nanotechnology Reviews:

Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode - PubMed Protein kinases are key regulators of numerous biological processes and aberrant kinase activity can cause various diseases, particularly cancer. Herein, we report the identification of new series of ...

🚀 🔬 Excited to share the work on Thieno[3,2-b]pyridine as a versatile scaffold for designing highly selective inhibitors of underexplored protein kinases.

#DrugDiscovery #MedicinalChemistry #KinaseInhibitors #ChemicalBiology #CancerResearch

Find out more: pubmed.ncbi.nlm.nih.gov/39503260/

Application of a macrocyclization strategy in kinase inhibitor development Explore how macrocyclization enhances kinase inhibitors, improving selectivity, overcoming resistance, and optimizing drug-like properties.

Explore how #macrocyclization enhances #kinaseinhibitors, improving selectivity, overcoming resistance, and optimizing #druglikeproperties.

Read More: amm-journal.org/index.php/20...

#Macrocyclizationstrategy #Drugdesign #Bindingaffinity #Kinaseselectivity @scienceopen.bsky.social

Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example The human kinome has tremendous medical potential. In the past decade, mixed-lineage protein kinase 3 (MLK3) has emerged as an interesting and druggable target in oncogenic signaling. The important ro...

Great to contribute to this study. We report on a target-hopping approach for the discovery of novel MLK3 inhibitors

pubs.acs.org/doi/10.1021/...

#KinaseInhibitors #DrugDiscovery #TargetedTherapies