Differential AXL expression and Arf1 regulation control stiffness-dependent Golgi organization in breast cancer cells Highlighted Article: An AXL-Arf1-Golgi signaling axis is a key mechanosensitive pathway that regulates Golgi organization and function, potentially linking matrix stiffness to tumor progression in bre...

Great to see this study from the lab now in print. The differential expression of AXL, and its regulation of Arf1 expression and activation, controls Golgi organization in breast cancer cells in a stiffness-dependent manner.

#matrix #mechanosensing #Golgi

journals.biologists.com/jcs/article/...

Working together, cells extend their senses Researchers at Washington University in St. Louis have found new rules for how groups of cells can sense beyond their surrounding environment, which can help in tracking how cancer moves and how wound...

And some #Mechanosensing research where I compare cancer cells to the Princess and the Pea. #ScienceSky 🧪🔬 ⚗️ #MechanoBiology source.washu.edu/2025/09/work...

Cell Collectives Extend Mechanical Sensing Far Beyond Their Environment

Cell clusters can deform collagen and sense mechanical cues up to 100 µm deep, far beyond the ~10 µm depth sensed by single cells, researchers report. Read more: getnews.me/cell-collectives-extend-... #mechanosensing #cellbiology #cancercells

💡 Join us in shaping the next frontier of #mechanobiology with Renaissance Philanthropy & @aria-research.bsky.social
If your work spans #tissuemechanics #cellmechanics #mechanomics #immunemechanics #mechanosensing, let’s connect - DM me!🔥

These discoveries highlight that Piezo-based mechanochemical signaling operates not as a simple ON/OFF switch, but rather as a rheostat, or dimmer switch. The regulatory logic behind this mode of Piezo action is an exciting direction for future research!
#mechanosensing #polyploidy #cellsize

LinkedIn This link will take you to a page that’s not on LinkedIn

Advertising a research fellow position in #Mechanosensing on a #BBSRC research project. An opportunity to join a fantastic team as part of the Comparative Biomechanics research group based in Leeds.

More details about the role from s.m.walker@leeds.ac.uk.

lnkd.in/emb6eEas

conference #eors2025 in Davos with an invited presentation of our postdoc Carlos Peniche Silva on #miRNA in #tendon in conjunction with #mechanosensing. Thanks to Roberto di Gesu and @ricgottardi.bsky.social for the invite and organization. @merln-um.bsky.social

In this seminar on #mechanomicrobiology, we learned how bacteria sense and respond to forces, and how understanding this can lead to alternative strategies to combat #AntibioticResistance. Thank you again Prof Alex Persat for visiting us at CIC biomaGUNE!
#mechanosensing #biofilms

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.

Cholinergic enteric neurons expressing Piezo1 sense mechanical forces to regulate gut motility and modulate intestinal inflammation.

#MechanoSensing

www.cell.com/cell/abstrac...

My next @prelights.bsky.social post is out. I saw this first preprint from @storerlab.bsky.social a while back and took some time over writing it but I think it was worth it! (1/2)

#preprint #regeneration #mechanosensing #ECM

Very happy to see the review I wrote on mechanosensing by the endoplasmic reticulum (ER) published @jcellsci.bsky.social! I’ve really enjoyed studying the ER and hope to contribute some research articles soon.

#EndoplasmicReticulum #review #mechanosensing

journals.biologists.com/jcs/article/...

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis - Nature Communications Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...

🔔🧪 Super interesting paper from the Sanz-Moreno group showing that the #ECMatrix influences #tumour #dissemination, with distinct #structure in different tumour regions that then affect #invasion patterns.

#cancer #metastasis #mechanosensing
#mechanoregulation

www.nature.com/articles/s41...

Check out our latest review in Current Opinion in Biomedical Engineering highlighting the critical role of dynamic cell #mechanosensing in fibrosis and cancer using #hydrogels 🧫

🚨Elegant study! @science.org 🆕🔥
✳️ #PIEZO-dependent #mechanosensing is essential for intestinal #stem cell fate decision and maintenance‼️
👉 www.science.org/doi/10.1126/...
#GutScience #GISky #GastroSky

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity - Nature Communications The crosstalk between cell-cell and cell-matrix adhesions regulates stem cell fate. Here, the authors reveal a critical role for matrix viscosity in controlling this crosstalk, which they explain via ...

Interested in how #stemcells sense their environment? Check out our work showing how #ECMatrix viscosity regulates #mechanosensing and #differentiation 🧪 Led by @theglasgowcemi.bsky.social @uofglasgow.bsky.social in collaboration with IBEC @natureportfolio.bsky.social
www.nature.com/articles/s41...

How do cells perceive mechanical cues? A three-year grant will allow @Vikram_Alva, @TBharat_lab, and @_Alex_Bisson_ to study #mechanosensing in #archaea and bridge the gap between eukaryotic and prokaryotic perception. Read more here:...