Forecasting Multitrait Resistance Evolution under Antibiotic Stress Abstract. Many bacteria rely on efflux pumps to survive antibiotic stress and exposure to antibiotics often leads to mutations in pump genes or their regul

@suvamroy.bsky.social @elibbyscience.bsky.social & @peteralind.bsky.social modeled gene expression in P. aeruginosa efflux systems, analysing how the complex regulatory networks associated with efflux pumps might evolve under antibiotic treatments.

🔗 doi.org/10.1093/molbev/msag065

#evobio #molbio

Age-dependent Phylodynamics with Application to Single-cell Lineage Trees Abstract. As novel technologies for single-cell lineage tracing emerge, phylogenetic and phylodynamic tools are increasingly being used to study developmen

Mulberry, Pilarski, Dinger, and @tanjastadler.bsky.social present a phylodynamic method that generalizes the traditional birth-death approach to model cellular dynamics to an age-dependent phylodynamic model.

🔗 doi.org/10.1093/molb...

#evobio #molbio

MBE | Soft Selective Sweeps Predominate in the Yellow Fever Mosquito Aedes aegypti

Ketchum, Matute & Schrider investigated positive selection in Aedes aegypti populations from Africa and the Americas, revealing that soft sweeps are more common than hard sweeps, implying this species can respond quickly to environmental stressors.

🔗 doi.org/10.1093/molbev/msag068

#evobio #molbio

MBE | Replicated hybrid zones reveal genomic patterns of local adaptation and introgression in spruce Photo: Sam Yeaman

Nocchi et al. compared hybridization and local adaptation within Canada spruce hybrid zones, discovering a complex pattern of introgression, with strong differences in ancestry maintained even across small spatial scales.

🔗 doi.org/10.1093/molbev/msag074

📷️ Sam Yeaman

#evobio #molbio #PlantSky

MBE Call for Papers on the Major Transitions of Life

MBE is excited to launch our newest Call for Papers on the Major Transitions of Life, covering all aspects of phylogenomic research.

🔗 academic.oup.com/mbe/pages/call-for-papers-on-the-major-transitions-of-life

Guest Editors:
Davide Pisani
Anja Spang

#evobio #molbio #phylogenetics

NF-κB: A Diverse and Multifunctional Transcription Factor in Holozoans Abstract. Transcription factor nuclear factor-kappa B (NF-κB) and many upstream signaling components have been identified in a diversity of holozoan taxa,

@ben-glass.bsky.social @daviesswphd.bsky.social et al. review recent progress in understanding NF-κB transcription factors in unicellular holozoans, Porifera, Placozoa, and Cnidaria, which are involved in multiple biological functions.

🔗 doi.org/10.1093/molbev/msag059

#evobio #molbio

MBE | April 2026 cover

The April issue of Molecular Biology and Evolution features the work of Gu et al., who performed large-scale phylogenomic analyses of the white-bellied pangolin.

🔗 academic.oup.com/mbe/issue/43/4

🖌️ Ting Bai

#evobio #molbio

Ancient genomes uncover dynamic cultural and genetic interplay in the eastern Tianshan Abstract. The eastern Tianshan range in Xinjiang, serving as a crucial link between the East and the West, acts as an important channel for the eastward sp

Yang et al. sequenced ancient individuals from the Bronze Age to historical periods in Xinjiang, revealing divergent genetic profiles of the western and eastern Tianshan, underscoring a complex population-culture interplay.

🔗 doi.org/10.1093/molbev/msag057

#evobio #molbio #humanevolution

Comparing Neanderthal Introgression Maps Reveals Core Agreement But Substantial Heterogeneity Abstract. Statistical methods to identify Neanderthal ancestry in modern human genomes rest on varying assumptions and inputs. Nonetheless, most studies of

@yaenc.bsky.social Velazquez-Arcelay & Capra compared 14 Neanderthal introgression maps, highlighting a core set of regions predicted by nearly all methods, as well as substantial heterogeneity in commonly used introgression maps.

🔗 doi.org/10.1093/molbev/msag064

#evobio #molbio #humanevolution

MBE | Highlight: Ancient oceans, New skeletons—innovations in silicon transport shaped sponge skeletal evolution

This month's article on skeleton evolution in sponges is the focus of a new Highlight by SMBE Fellow Ioanna Kotari @janekay27.bsky.social

Highlight: Ancient oceans, New skeletons—innovations in silicon transport shaped sponge skeletal evolution
🔗 doi.org/10.1093/molbev/msag054

#evobio #molbio

MBE | Evolutionary genomic basis of mimicry diversity of Epicopeiidae moths

Li et al. studied the genomic basis of mimicry in Epicopeiidae moths, finding that TE-driven regulatory innovation rewired developmental gene networks, facilitating the emergence of multiple mimetic forms.

🔗 doi.org/10.1093/molbev/msag060

#evobio #molbio #mimicry

MBE | From Adam's rib: the Siberian moth's female W chromosome is derived from its Z counterpart Dendrolimus laying eggs on the needles of a conifer. Author: V. V. Remorov

Shipova et al. show that the female W chromosome of the Siberian moth pest is derived from the male Z, proposing that this mechanism may be common in lepidopteran evolution to counteract non-recombining chromosome degeneration.

📷 V. V. Remorov

🔗 doi.org/10.1093/molbev/msag055

#evobio #molbio

An enzyme's metal preference evolves through redox modulation driven by the cofactor's secondary coordination sphere Abstract. Changes in protein properties and functions are central to the evolution of life. Metalloproteins can evolve by changing their preference from on

Mackenzie, @waldronlab.bsky.social et al. argue that differing superoxide dismutase metal preferences observed across the tree of life evolved through tuning of their redox properties by the secondary coordination sphere.

🔗 doi.org/10.1093/molbev/msag040

#evobio #molbio

Displacement-Optimized Tanglegrams for Trees and Networks Abstract. Phylogenetic trees and networks play a central role in biology, bioinformatics, and mathematical biology, and producing clear, informative visual

Daniel Huson introduces displacement-optimized tanglegrams (DO-tanglegrams), a new approach that applies equally to trees and rooted phylogenetic networks, performing better than cophylo on trees and then NN-tanglegram on networks.

🔗 doi.org/10.1093/molbev/msag066

#evobio #molbio #compbio

piqtree: a python package for seamless phylogenetic inference with IQ-TREE Abstract. piqtree (pronounced pie-cue-tree) is an easy to use, open-source Python package that provides Python script based control of IQ-TREE’s phylogenet

McArthur et al. present piqtree, an easy to use, open-source Python package that provides Python script based control of IQ-TREE’s phylogenetic inference engine.

🔗 doi.org/10.1093/molbev/msag061

#evobio #molbio #compbio

MBE | Stoichiometry-induced differential selection on codon optimization among ribosomal protein genes in bacterial species

@xuhuaxia.bsky.social shows that codon usage in bacteria is more optimized in long ribosomal protein genes; results demonstrate that translation optimization reflects functional stoichiometry and protein length constraints.

🔗 doi.org/10.1093/molbev/msag062

#evobio #molbio

#quotes #books #booksky #excerpts #citations #howtogrowahuman #ball #gene #genome #genenetwork #complexity #interaction #molbio #genes #blackbox

MBE | Innovations in Silicon Transport Shaped the Rise of Biosilicification and Skeletal Evolution in Sponges

Leria and Maldonado show sponge's skeletons likely arose as an adaptive response in early askeletal sponges to the damaging, silicic acid-rich Precambrian oceans; this adaptation evolved independently four times within Porifera.

🔗 doi.org/10.1093/molbev/msag047

#evobio #molbio #sponge

OrthoGarden: a pipeline for propagating phylogenetic trees for nonmodel organisms from short reads and de novo genome assemblies Abstract. Phylogenomics pipelines are designed to reconstruct evolutionary relationships among groups of organisms. Existing pipelines are dependent upon r

Turner et al. introduce OrthoGarden, an automated and containerized de novo assembly-based phylogenomics pipeline aimed at recovering accurate and reproducible phylogenies from any combination of short reads and assemblies.

🔗 doi.org/10.1093/molbev/msag053

#evobio #molbio #compbio

Escape from X inactivation drives sex differences in gene expression Abstract. X chromosome inactivation (XCI) partially balances gene dosage between sexes; yet, many genes are expressed from the inactive X (Xi) to a variabl

@carriezhu.bsky.social , @xliaoyi.bsky.social & @arbelharpak.bsky.social find that inactive X expression levels are a strong linear predictor of female-male expression differences.

🔗 doi.org/10.1093/molb...

#evobio #molbio

📢 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐂𝐮𝐫𝐫𝐞𝐧𝐭 𝐂𝐞𝐥𝐥 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 🧪

Submit your research, reviews, or letters on significant advances in cell biology and integrative science. 🧬

📌 Editor-in-Chief: Masayoshi Yamaguchi
🔗 Submit here: https://bit.ly/4blRwOR

#CellBiology #MolBio #Bioscience #ScienceSky #AcademicSky

HaploThread: a scalable desktop tool for efficient haplotype network inference and interactive visualization Abstract. This note introduces HaploThread, a user-friendly desktop software with a graphical user interface designed for constructing and visualizing hapl

Xu et al. introduce HaploThread, a user-friendly desktop software with a graphical user interface designed for constructing and visualizing haplotype networks.

🔗 doi.org/10.1093/molb...

#evobio #molbio #compbio

MBE | Holostean genomes reveal evolutionary novelty in the vertebrate immunoproteasome that have implications for MHCI function

Barker et al. investigate the evolution of PSMB8, a core component of the immunoproteasome, suggesting that the unique PSMB8 types in holosteans contribute to a molecular basis of immune surveillance that is unlike that of other vertebrates.

🔗 academic.oup.com/mbe/article/...

#evobio #molbio

The Genetic Architecture of Venom Resistance: A Novel Approach to Target Identification and Coevolutionary Discovery Abstract. All species evolve under selective pressures that emerge from their interactions, often antagonistic, with other species. Phenotypes mediating sp

Ward, @drokyta.bsky.social et al. investigated the genetics of venom resistance using venom of the Florida blue centipede and Drosophila melanogaster as model prey, revealing a stark contrast in the nature of venom resistance between prey sexes.

🔗 doi.org/10.1093/molbev/msag048

#evobio #molbio

MBE | Large-scale genomic phylogeography provides insights into evolutionary history and conservation priorities of the white-bellied pangolin (Phataginus tricuspis)

Gu et al. leveraged hundreds of genomes and mitogenomes of the African white-bellied pangolin, uncovering the evolutionary history of this species and indicating the need for urgent attention and priority conservation action.

🔗 doi.org/10.1093/molbev/msag049

#evobio #molbio

Intraspecific genome size variation is attributed to adaptive silencing of transposable elements in Hordeum species Abstract. A substantial variation in genome size has been observed among individuals of the same species. Theory predicts that increased genome size may co

Potapenko et al. studied two species of barley, finding that TE silencing is central to genome size regulation, with selection maintaining smaller genomes among individuals with higher fitness in favorable habitats.

🔗 doi.org/10.1093/molbev/msag051

#evobio #molbio #TEsky #PlantSky

Molecular Biology and Evolution | March 2026 cover

The March cover of Molecular Biology and Evolution features the work of Leria and Maldonado, who investigated biosilicification and skeletal evolution in sponges.

Follow the link for this month's articles:
🔗 academic.oup.com/mbe/issue/43/3

#evobio #molbio #societyjournal

Molecular clock dating using complex mixture models: applied to ancient symbionts Abstract. Molecular clocks are a fundamental technique in evolutionary biology for establishing the timing and tempo of organismal divergence. However, cur

@sishuowang.bsky.social & Meade introduce phyloHessian, using complex mixture substitution models in molecular dating. Empirical analysis of ancient symbiont lineages leads to a revised understanding of their host association origins.

🔗 doi.org/10.1093/molbev/msag039

#evobio #molbio #compbio

Tiny, 45 base long RNA can make copies of itself Self-copying RNAs may have been a key stop along the pathway to life.

🔄 Tiny, 45 base long RNA can make copies of itself

arstechnica.com/science/2026...

#rna #molecules #replication #molbio

Defective splicing of Y-chromosome-linked gigantic genes contributes to hybrid male sterility in Drosophila Abstract. The Y chromosome evolves rapidly, often differing dramatically even between closely related species. While such divergence has long been suspecte

Fontan et al. show that sequence divergence within introns can disrupt essential gene expression through defective splicing, providing a mechanistic link between rapid Y chr. evolution and hybrid sterility.

🔗 doi.org/10.1093/molbev/msag045

#evobio #molbio #drosophila

@jullienflynn.bsky.social