Another of my favourite 2024 #NatRevMCB covers highlights our Review on #somitogenesis by Yuchuan Miao and Olivier Pourquie.

We were inspired by the rows of forming somites that resemble rows of seat on a train or plane and their patterning by Hox genes!

🔗 go.nature.com/3Vx3psy

Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...

📢 New @natrevmcb.bsky.social Review!

Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research.

go.nature.com/3ZxZuhS

#NatRevMCB

How proteins sense their cellular environment - Nature Reviews Molecular Cell Biology In this Comment article, Monika Fuxreiter discusses possible roles of dynamic, fuzzy protein interactions and their importance in changing cellular environments.

✨New #NatRevMCB Comment online!✨

Fuxreiter (University of Padova) discusses how proteins decode information from their cellular environment and proposes that "fuzzy" interactions with functional partners provide a readout mechanism.

👉 go.nature.com/3Bf7qLn

NRMCB's February 2024 cover featuring a number of hairy Highland cows that look very cute.

As 2024 is slowly drawing to a close (???), I want to highlight my favourite #NatRevMCB covers of the year 🤩

Here's the first of them: Our February cover with the cutest highland cows - inspired by our Review on the hair follicle stem cell niche by Zhang & Chen.

👉https://go.nature.com/416e5SS

My continued biological education

Fundamentals of Redox regulation in biology

Functions: Metabolism, Epigenetics (SIRT1, MLL), Transcription (NRF2, NFκB, HIF1), Protein translation/folding/degradation, Kinase signaling, Programmed cell death

#NatRevMCB 2024
www.nature.com/articles/s41...

Long non-coding RNAs: definitions, functions, challenges and recommendations

3 categories of non-coding RNAs
1⃣<50 nt
small RNA
2⃣50-500 nt
PolIII/PolV transcripts, PolII small transcripts (snRNA snoRNA [miRNA?])
3⃣>500 nt
#LncRNA

#NatRevMCB 2024
www.nature.com/articles/s41...

My continued biomechanic education

Adherens junctions as molecular regulators of emergent tissue mechanics

1⃣#TissueFluidization

2⃣Tools to measure tissue mechanics

3⃣Cellular unjamming, Collective cell motility, EMT

#NatRevMCB 2024
www.nature.com/articles/s41...

My continued biological education

Patterning of the cell cortex by Rho GTPases

Self-organizing Zonation/Flux😍

RhoGTPase in plasma membrane repair

Live cell imaging for spatiotemporal Rho activities

#NatRevMCB 2024
www.nature.com/articles/s41...

A guide to cell death pathways
#Apoptosis
#Necroptosis
#Pyroptosis
Autophagic/Lysosomal cell death
#Ferroptosis
#Entosis/Cell Cannibalism
#Excitotoxicity/Ion disequilibrium

Archived for learning & writing

Junying Yuan & Dimitry Ofengeim #NatRevMCB 2024
www.nature.com/articles/s41...

CRISPR technologies for genome, epigenome & transcriptome editing

Dazzling ever-expanding Cas-verse😎
#BaseEditing
#PrimeEditing
Large insertions/deletion kb
Transient/Stable transcriptional activation/inhibition
RNA degradation/editing/methylation🤠

#NatRevMCB 2024
www.nature.com/articles/s41...

My continued biological education
The molecular basis for cellular function of intrinsically disordered protein regions

From Sequence to Ensemble
As linker
As binding interface
As cellular sensor
▶️Condensate
alexholehouse.bsky.social & Birthe Kragelund #NatRevMCB 2023
www.nature.com/articles/s41...