RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal #necroptosis in TNF-treated mice, say Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang and colleagues rupress.org/jem/article/...

📘 In our #InnateImmunity collection: rupress.org/jem/collecti...

#KSInnateImmune26

RIPK1-driven #necroptosis in both tumor and stromal compartments found to be essential for effective immunogenic cell death-based therapy and immune checkpoint @meierlabicr.bsky.social doi.org/10.1038/s414...

#Research by Zhou Wu, Lukas Henning, Christian Steinhäuser and Peter Bedner from @unibonn.bsky.social finds that targeting #necroptosis protects against #astrocyte death and hippocampal sclerosis in experimental temporal lobe #epilepsy 🧠 🔬

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Researchers map the interplay of #ProgrammedCellDeath after #IschemicStroke, showing early #ferroptosis and #necroptosis followed by #apoptosis, with iron driving both—highlighting the potential of concurrently targeting multiple death mechanisms.

Read: doi.org/10.1016/j.ge...

Discovery based on SPR drug chip that corilagin alleviates acute lung injury in mice by inhibiting necroptosis through targeting RIPK1/RIPK3/MLKL pathway Necroptosis, a necrotic form of regulated cell death, plays a crucial role in various tissues and disorders, including sepsis. This process occurs pri…

🌿 Corilagin & Acute Lung Injury

A new #CJNM study shows that corilagin reduces lung inflammation by inhibiting RIPK1/RIPK3/MLKL-mediated necroptosis and restoring mitochondrial integrity in mouse models.

🔗 Read full article on ScienceDirect

#AcuteLungInjury #Necroptosis #NaturalMedicine #CJNM

P. gingivalis in #Atherosclerotic plaques exacerbates plaque instability by disrupting the FOXO3-HDAC2 axis, driving #OxidativeStress-mediated macrophage #Necroptosis, thus establishing a causative link between periodontal health and #ASCVD.

#OpenAccess: doi.org/10.1038/s413...

Client Challenge

This week #JournalClub @labsoap.bsky.social @nature.com #celldeath #plasmamembrane #rupture #MLKL #necroptosis www.nature.com/articles/s41...

A caspase 8 deletion #SCLC mouse model promotes a neuronal progenitor-like cell state and pre-tumoral immunosuppression triggered by #necroptosis that promotes metastasis @vonkarstedtlab.bsky.social
@unicologne.bsky.social
@dtg-cologne.bsky.social
@cecad.bsky.social
doi.org/10.1038/s414...

Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression - Nature Communications Caspase 8 protein expression is largely absent in small cell lung cancer (SCLC) patients. Here, the authors generate a caspase 8 deletion SCLC mouse model and show that it promotes a neuronal progenit...

What a nice way to end 2025: absence of caspase 8 in #sclc leads to neuronal-like reprogramming and promotes #metastasis via #necroptosis driven #inflammatory response. Congratulations to Ariadne and collaborateurs @unicologne.bsky.social @dtg-cologne.bsky.social !
www.nature.com/articles/s41...

Porphyromonas gingivalis infection exacerbates #Atherosclerotic plaque destabilization by promoting #OxidativeStress-mediated #necroptosis in lipid-laden macrophages via upregulating MSR1 expression. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

A new study highlights a non-canonical role of the S6K1–SGK1 pathway in #Necroptosis during #TBI, identifying it as a promising therapeutic target for TBI and other necroptosis-related conditions. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal #necroptosis in TNF-treated mice, say Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang and colleagues rupress.org/jem/article/...

#InnateImmunity #Inflammation

Porphyromonas gingivalis infection exacerbates #Atherosclerotic plaque destabilization by promoting #OxidativeStress-mediated #necroptosis in lipid-laden macrophages via upregulating MSR1 expression. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy - Nature Cell Biology Yang, Li, Huang, Ji, Luo, Jiang and colleagues report that chemotherapy induces MLKL PARylation and necroptosis in tumour endothelial cells, which in turn affects tumour-associated macrophages and CD8⁺ T cells, promoting immunosuppression and tumorigenesis.

💫NEW: Yang, Li, Huang, Ji, Luo, Jiang et al report that chemotherapy induces MLKL PARylation and #necroptosis in tumor endothelial cells, which in turn affects tumor-associated #macrophages and CD8⁺ T cells, promoting #immunosuppression and tumorigenesis.
👉https://rdcu.be/eHUob
bit.ly/4njRM4p

👋Our September issue's out!
Cover: Oncofusion condensates

👉🏼Review on #hematopoietic #aging
🔬 #StemCells #trophectoderm #immunotherapy #fibrosis #cancer #necroptosis #chromatin #mitosis #mitophagy #ProteinFolding #BiomolecularCondensates #organelles & more!
www.nature.com/ncb/volumes/...

STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD

STING drives #necroptosis, and here’s how it does it!
Congratulations to @gianmaria-liccardi.bsky.social and his amazing team!

www.nature.com/articles/s41...

MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction Necroptosis drives inflammation through membrane rupture-mediated DAMPs release. Independently of membrane damage, Ding et al. revealed phosphorylated MLKL permeabilizes mitochondrial membranes and in...

#WeekendRead! #NoTimeToDie! #InterferonPower! Wang &co show @cp-molcell.bsky.social that MLKL not only drives #necroptosis but also directly triggers IFNb production by releasing mitochondrial DNA & activating cGAS-#STING, which exacerbates #colitis! www.cell.com/molecular-ce...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

Outstanding paper where scientists discover Mlkl isoforms that differently regulate necroptosis and a drugable target against the necroptotic activity of Mlkl. Congratulations Uris Ros, Ana Garcia Sáez and everyone involved
#necroptosis

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

#Medsky🧪 #immunosky #oncosky understanding the roles & underlying mechanisms of p53-mediated non-apoptotic cell death pathways, incl #ferroptosis, #necroptosis, #pyroptosis, #autophagy , entotic cell death, parthanatos , #paraptosis & may regulate #PANoptosis, #cuproptosis & #disulfidptosis .

Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke

Mechanistic insights on how iron-mediated #RedoxImbalance potentiates #Necroptosis via the RIPK1-RIPK3-MLKL pathway & increases susceptibility to #Ferroptosis in the early stages of #IschemicStroke (IS). #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Deubiquitination of #RIPK3 by OTUB2 potentiates neuronal #necroptosis after #IschemicStroke 🧠

By Fuqi Mei, Xu Wang & colleagues at Wenzhou Medical University

➡️ doi.org/10.1038/s443...

Top: Alignment of RHIM sequences from human RIPK3 (hRIPK3) and mouse RIPK3 (mRIPK3). Several variable residues between hRIPK3 and mRIPK3 were highlighted. Right: Structural comparison between mZBP1-mRIPK3 and hZBP1-hRIPK3 complexes. mZBP1 was colored in yellow, mRIPK3 in light green, hZBP1 in orange, and hRIPK3 in dark green. Hydrogen bonds were indicated by gray dotted lines. Left: Multiple sequence alignment of RIPK3 protein sequences from Primate and Rodent species. The conservative RHIM core amino acids were highlighted with a star (*). The variable residues between human and mouse were highlighted with a red box. Bottom: Schematic model of the proposed ZBP1-driven necroptosis in both human and mouse cells during HSV-1 (ICP6mut) infection (created with BioRender.com).

ZBP1 initiates RIPK3-mediated #necroptosis during #viral infection in mouse cells, but what about human cells? This study shows that in humans RIPK1 is required for HSV-induced ZBP1-dependent necroptosis; RIPK1's RHIM motif dictates this species difference 🧪 @plosbiology.org plos.io/3QxqHfe

Top: Alignment of RHIM sequences from human RIPK3 (hRIPK3) and mouse RIPK3 (mRIPK3). Several variable residues between hRIPK3 and mRIPK3 were highlighted. Right: Structural comparison between mZBP1-mRIPK3 and hZBP1-hRIPK3 complexes. mZBP1 was colored in yellow, mRIPK3 in light green, hZBP1 in orange, and hRIPK3 in dark green. Hydrogen bonds were indicated by gray dotted lines. Left: Multiple sequence alignment of RIPK3 protein sequences from Primate and Rodent species. The conservative RHIM core amino acids were highlighted with a star (*). The variable residues between human and mouse were highlighted with a red box. Bottom: Schematic model of the proposed ZBP1-driven necroptosis in both human and mouse cells during HSV-1 (ICP6mut) infection (created with BioRender.com).

ZBP1 initiates RIPK3-mediated #necroptosis during #viral infection in mouse cells, but what about human cells? This study shows that in humans RIPK1 is required for HSV-induced ZBP1-dependent necroptosis; RIPK1's RHIM motif dictates this species difference 🧪 @plosbiology.org plos.io/3QxqHfe

Top: Alignment of RHIM sequences from human RIPK3 (hRIPK3) and mouse RIPK3 (mRIPK3). Several variable residues between hRIPK3 and mRIPK3 were highlighted. Right: Structural comparison between mZBP1-mRIPK3 and hZBP1-hRIPK3 complexes. mZBP1 was colored in yellow, mRIPK3 in light green, hZBP1 in orange, and hRIPK3 in dark green. Hydrogen bonds were indicated by gray dotted lines. Left: Multiple sequence alignment of RIPK3 protein sequences from Primate and Rodent species. The conservative RHIM core amino acids were highlighted with a star (*). The variable residues between human and mouse were highlighted with a red box. Bottom: Schematic model of the proposed ZBP1-driven necroptosis in both human and mouse cells during HSV-1 (ICP6mut) infection (created with BioRender.com).

ZBP1 initiates RIPK3-mediated #necroptosis during #viral infection in mouse cells, but what about human cells? This study shows that in humans RIPK1 is required for HSV-induced ZBP1-dependent necroptosis; RIPK1's RHIM motif dictates this species difference 🧪 @plosbiology.org plos.io/3QxqHfe

https://www.sciencedirect.com/science/article/pii/S235230422400059X

Iron impairs the redox balance to activate #Necroptosis via the RIPK1-RIPK3-MLKL pathway & increases susceptibility to #Ferroptosis during the early stages of reperfusion post-cerebral #IschemicStroke.

#OpenAccess: https://buff.ly/4huyztc

Mitochondria and cell death - Nature Cell Biology Several processes of regulated cell death engage or use mitochondria, which are thus central hubs that not only coordinate cell death but also elicit non-lethal signalling mediated by mitochondrial ou...

☕This year, in our #CellDeath focus:
Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis
👉https://rdcu.be/d46gt
www.nature.com/articles/s41...

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction–associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease ma...

Hi bluesky, just wanted to share our most recent paper from the
@katelawlorlab.bsky.social showing distinct roles for #necroptosis effectors RIPK3 (+ Caspase-8) that drives inflammation, and MLKL which regulates lipid handling in obesity-induced #MAFLD. www.life-science-alliance.org/content/8/1/...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

An intracellular bacterial pathogen triggers RIG-I/MDA5-dependent necroptosis.

Edwardsiella tarda induced a RIPK3-dependent #necroptosis in RAW264.7 cells. Infection activated the RIG-I/MDA5 pathway.

www.sciencedirect.com/science/arti... #OpenAccess

Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium Z-RNA/ZBP1–induced necroptosis is an initiating cell death event that occurs markedly more with Delta than Omicron infection.

#MesSky🧪#IDSky #Necroptosis is the primary type of cell death affecting human lung cells at the start of #SARSCoV2 infection, Understanding how #SARSCoV2 causes #celldeath is essential to understand the pathogenic processes underlying severe #COVID19.

www.science.org/doi/10.1126/...