#CRISPR Cas3 produces variable long deletions upstream of PAM (~80% upstream, ~20% downstream)

Here is an elegant example for Cas3 editing of transthyretin/TTR in 👤cells & 🐭

~9kb mean deletion

8-mo humanized 🐭liver by 1 wk
👉⏬75% serum human TTR

#NatureBiotech 2026
www.nature.com/articles/s41...

PRISM
profiling of RNA in situ through Single-round imaging

#SpatilaOmics

Up to 64 plex
Spectral barcoding

30-gene panels for 3D spatial mapping of human tumors, mouse brain & mouse embryos

Only a conventional confocal microscope needed

#NatureBiotech 2025
www.nature.com/articles/s41...

Monomethyl fumarate α-ketoester enables #OxidativeStress/Peroxide-dependent release at the site of tissue injury

NRF2-activating effects validated in mouse pain models of peripheral nerve injury or osteoarthritis

#NatureBiotech 2024
www.nature.com/articles/s41...

Spotlight on cancer immunotherapies - Nature Biotechnology Advances in cancer immunotherapy have shown promising results for treatment of tumors, yet challenges related to therapeutic efficacy and manufacturing processes need to be overcome.

Spotlight on #CancerImmunotherapy: Promising progress in treating tumors, but challenges remain in boosting efficacy & streamlining manufacturing. #TCSC #Immunotherapy #CancerResearch #Biotech #Oncology #NatureBiotech #PrecisionMedicine

www.nature.com/articles/s41...

Comprehensive genome analysis and variant detection at scale using DRAGEN - Nature Biotechnology DRAGEN rapidly identifies diverse types of genetic variants.

A peer reviewed publication in #NatureBiotech highlights the comprehensiveness, accuracy & scalability of #Illumina #DRAGEN germline algorithms. Get access to the data, truth sets used, & detailed analysis steps. Read the publication to learn more: go.nature.com/48qWp5R

CARD
Conditional AutoRegressive-based cell-type Deconvolution #SpatialTranscriptomics

Work on #Visium ST #SlideseqV2

Gaussian kernel to model #SpatialCorrelation

Impute cell type & gene info at unmeasured locations

#NatureBiotech 2022
www.nature.com/articles/s41...

iSTAR (Inferring Super-resolution Tissue ARchitecture)
Predict spatial gene expression at single-cell & whole-transcriptome level

based on #Xenium (<1000 genes) #Visium (Not single-cell) #SpatialTranscritomics + HE histology

#Superpixel

#NatureBiotech 2024
www.nature.com/articles/s41...

#Baysor

#CellSegmentation for 2D 3D image-based #SpatialTranscriptomics

Based on Transcript composition #MarkovRandomField
-/+Stain image #PriorSegmentationConfidence

Work with #MERFISH #smFISH #STARmap
⏫Detection of vascular cells

#NatureBiotech 2022
www.nature.com/articles/s41...