#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut– #Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut– #Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reveal that tryptophan (Trp) metabolism is regulated by distinct cellular “checkpoints” along the gut–brain axis, finely modulated by sex differences, circadian rhythms, and microbiome composition. However, current interventions tackle single levers in isolation, leaving a key gap in the precision control of Trp’s fate. To address this, we drew upon an extensive body of the primary literature and databases, mapping enzyme expression across tissues at single-cell resolution and linking these profiles to clinical trials investigating dual indoleamine 2,3-dioxygenase 1 (IDO1)/tryptophan 2,3-dioxygenase (TDO) inhibitors, engineered probiotics, and chrono-modulated dosing strategies. We then developed decision-tree algorithms that rank therapeutic combinations against biomarker feedback loops derived from real-time saliva, plasma, and stool metabolomics. This synthesis pinpoints microglial and endothelial KYN hotspots, quantifies sex-specific chronotherapeutic windows, and identifies engineered Bifidobacterium consortia and dual inhibitors as synergistic nodes capable of reducing immunosuppressive KYN while preserving neuroprotective kynurenic acid. Here, we highlight a framework that couples lifestyle levers, bio-engineered microbes, and adaptive pharmaco-regimens into closed-loop “smart protocols.” By charting these intersections, this study offers a roadmap for biomarker-guided, multidisciplinary interventions that could recalibrate KYN metabolic activity across cancer, mood, neurodegeneration, and metabolic disorders, appealing to clinicians, bioengineers, and systems biologists alike.

#Tryptophan’s fate 🔥 decides between #Mood 🧠, #Cancer ⚖️, or #Neurodegeneration!🧬Our study exposes #KYN checkpoints⚡ shaping the #Gut– #Brain axis!
#NeuroImmunity #Kynurenine @mdpiopenaccess.bsky.social
👉 www.mdpi.com/2227-9059/13...

JCI - Immune cells promote paralytic disease in mice infected with enterovirus D68

New JCI paper led by postdoc Mikal Woods Acevedo shows immune cell infiltration—not viral load—drives paralysis in mice infected with enterovirus D68. Points to new targets for AFM treatment.
🔗 doi.org/10.1172/JCI1...
#Virology #NeuroImmunity #PostdocSpotlight #AFM

2025 Neuroimmune Communication in Health and Disease Conference GRC The 2025 Gordon Research Conference on Neuroimmune Communication in Health and Disease will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

Another exciting conference! I am attending this week the #GRC of #Neuroimmunity in Lucca representing @plosbiology.org

Really cool talks and people in a beautiful place!

Looking forward to it!

www.grc.org/neuroimmune-...

Meet Eduardo Oliveira, a bioinformatician supporting the Neuroimmune Interactions Lab.

Meet Eduardo Oliveira, a bioinformatician supporting the Neuroimmune Interactions Lab. umassmed.edu/neurology/re... #neurology #research #neuroimmunity

7/12. For the #immunology enthusiasts @LukensJohnR - Dr. John Lukens shares the latest breakthroughs in immune cell biology, #neuroimmunity and the #GutMicrobiome, especially in the context of neurological diseases