An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons This work introduces an open-source all-optical platform for functional phenotyping of human stem cell-derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and...

Publication alert! We built an #opensource platform for functional phenotyping of hiPSC-derived #neurons, combining calcium #imaging, #optogenetic stimulation, #automated acquisition and analysis into an accessible workflow. @fedegasparoli.bsky.social @sahinm.bsky.social @sciwhye23.bsky.social

#optogenetic #neuroskyence
#science

OUTLOOK: Rewiring gene circuits to dissect oscillatory signaling dynamics
By Marek van Oostrom and Katharina Sonnen
➡️ https://genesdev.cshlp.org/content/40/1-2/1.full

Read the full story:
➡️ https://genesdev.cshlp.org/content/40/1-2/124.full

Ina Sonnen Hubrecht Institute
#optogenetic #segmentation

RESOURCE/METHODOLOGY: Synchronization of the segmentation clock using synthetic cell–cell signaling
By Akihiro Isomura, Daisuke Asanuma, and Ryoichiro Kageyama
➡️ https://genesdev.cshlp.org/content/40/1-2/124.full

#optogenetic #signaling #segmentation #notch

Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression:
doi.org/10.1002/btm2...

#myoblue

James Briscoe on #morphogen #gradients and #optogenetic modifications in development #insdb2025 @insdb.bsky.social

Development of blue light activated, kinetically balanced ChR variants optimized for high-frequency #optogenetic stimulation of SGNs at low light intensities
#cochlearimplants

By L. Roos, T. Moser, T. Mager & colleagues at University Medical Center Göttingen

🗞️ doi.org/10.1038/s44321-025-00350-z

2DNEURO is now offering an 8-channel TTL wireless optogenetic system! You can stimulate up to 8 animals simultaneously — perfect for operant conditioning setups. I currently have 4 systems available. If you're interested, please get in touch! #neurskyence #optogenetic #brain

I received a lot of emails lately for orders at 2DNEURO. No worries I saw them, and will reply ASAP. New products coming regularly... But soon I will do a major update on the website #neuroskyence #neuroscience #optogenetic

I am asked very often if other wireless optogenetic device are good, this is my reply. #Neuroskyence #Neuroscience #optogenetic

2DNEURO wireless optogenetic device start at 750$ +tax. This is for one coil system. Cheapest than a laser for optogenetic and no patch cord or rotary joint to buy!! #optogenetic #neuroskyence

2D Neuro Personalized approach for behavioral and electrophysiology experiments in preclinical studies.

With funding increasingly difficult to obtain, and projects that need to move forward, using wireless multi-animal optogenetics is the way to go. 2DNEURO.com offers up to 3 months trials for our various products, and our prices are the lowest. Contact for demo!! #neuroscience #optogenetic #DBS

GitHub - rly/ndx-optogenetics: NWB extension for optogenetics metadata NWB extension for optogenetics metadata. Contribute to rly/ndx-optogenetics development by creating an account on GitHub.

15/
Why I’m proud ❤️
Along the way, we realized that the neural data standard (NWB) format couldn’t log the #optogenetic metadata we needed.

So, with Ryan Ly (LBNL), we built a brand-new opto-NWB extension. Available for public use here:
👉 github.com/rly/ndx-opto...

@ryanly.bsky.social

Drs. @dbenzinger.bsky.social‬ and @jamesbriscoe.bsky.social at the @crick.ac.uk established an #optogenetic system for the precise spatiotemporal control in vitro of Sonic hedgehog morphogen production. 🦔

📄 - https://bit.ly/3Vxf0rf
🎙️ - https://bit.ly/3JWWpT9

New perspectives on #optogenetic #VisionRestoration
In my letter in @moltherapy.bsky.social‬, I comment on recent clinical data on vMCO-010 and highlight the need for mechanistic insight & objective efficacy measures.
Many open questions remain - exciting times ahead! @unimarburg.bsky.social #Retina

This review provides a comprehensive overview of #Optogenetic applications across brain regions to investigate the mechanisms underlying #Depression. It also highlights current challenges and future directions in the field. #medsky #MentalDisorder

Read: link.springer.com/article/10.1...

#neuroscience #science #neuroskyence #optogenetic

Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩

We replicated the behavioral effects using #optogenetic inhibition of IPN projections to the LDTg. This validates the IPN's role as a regulatory brake on the nicotine reward circuit.

New day, new order for 2DNEURO this one is going to China for stimulation of the spinal cord! Remember we are the only one with wireless and battery less optogenetic stimulation and we provide the lowest priced product. #neuroscience #neuroskyence #biology #optogenetic

4/ We establish #optogenetic and pharmacological tools to experimentally engineer pluripotent tissues to undergo material phase transitions using different combinations of the control parameters. How does each parameter contribute to tissue rheology?

Researcher Subcellular Optogenetics at the Neurosciences Research Center DM.65.25 part-time | 28.03.2025 | Campus Charité Mitte

🚨We have an open position in the lab for the engineering of new #optogenetic tools for light control of #subcellular biology!💡🧠🔬 Interested? Get in touch or apply 👍

karriere.charite.de/en/job-vacan...

Diagram of Optogenetic methods to stimulate gamma motor neuron axons ex vivo

💡Karekal et al. used #optogenetic stimulation with a blue LED and an ex vivo setup, integrating an #AuroraScientific dual-mode lever system and stimulator to study gamma motor neuron function and the fusimotor system’s role in motor control and disease.

doi.org/10.1113/ep09...

🐭🧠 We study communication in brain networks, combining #MRI with #ephys, #brainstimulation (electrical and #optogenetic) and behavioral experiments. We are interested in #memory updating and psychiatric conditions, taking a translational approach.
#addiction
#alcohol
#neuromodulation

#Introduction

2DNEURO is on BlueSky. Interested in wireless optogenetic stimulation, feel free to contact us 2DNEURO.com Implant available for in cage stimulation cortical subcortical and periphery (stomach, spinal cord, in utero) #optogenetic
#neuroscience

#LITOS: A versatile #OpenSource #LED #illumination tool for #optogenetic stimulation:

-32 × 64 LED matrix
-#ESP32-controlled via #WLAN
-usable with different formats of multi-well plates, petri dishes & flasks.

doi.org/10.1038/s415...
#DIYbio #lab #instruments #optogenetics

#OptoPi: An #OpenSource #3Dprinted flexible platform for the analysis of small #animal #behaviour:

-customisable #VIS/#IR #illumination, allows for #optogenetic stimulation
-#imaging by #RaspberryPi #camera
-#Arduino control

doi.org/10.1016/j.oh...
#DIYbio #lab #instruments

This is cool & has neat implications:

They engineered Lactococcus lactis to produce GABA, GCSF, or GLP1 when exposed to light (#Optogenetic activation) and tested functional #probiotic effects in vivo.

Thanks for sharing, Henry Darch!...