High PLMS frequency was independently associated with accelerated deterioration in executive function, suggesting a link between #PLMS and cognitive aging. In contrast, #RLS symptoms showed no association with changes in cognitive function.

Clinical practice recommendations for treatment of #restlesslegssyndrome ( #RLS) and periodic limb movement disorder ( #PLMD) in adults and pediatric patients.
doi.org/10.5664/jcsm...
#SleepDisorders
#PLMS

Protein language models are revolutinizing protein engineering and design. Our goal is to apply them for #enzyme discovery and design for the degradation of plastic polymers

#PLMs #PlasticDegradation #BIORE2AIRCRAFT #AtracciónTalento

@comunidadmadrid.bsky.social
@icp-csic.bsky.social

Pero ¿𝘀𝗼𝗻 𝘁𝗼𝗱𝗼𝘀 𝗹𝗼𝘀 𝗲𝘅𝘁𝗿𝗲𝗺𝗼́𝗳𝗶𝗹𝗼𝘀 𝗶𝗴𝘂𝗮𝗹𝗲𝘀? La hipótesis es que extremófilos presentan patrones estructurales, funcionales y adaptativos modulados por su #biogeografía, que pueden descifrarse mediante 𝗺𝗼𝗱𝗲𝗹𝗼𝘀 𝗱𝗲 𝗹𝗲𝗻𝗴𝘂𝗮𝗷𝗲 𝗱𝗲 𝗽𝗿𝗼𝘁𝗲𝗶́𝗻𝗮𝘀 #pLMs entrenados a partir de las secuencias de los microbiomas.
5/7

8/ #AllergyResearch #AI #pLMs #DeepLearning #Microbiome #Immunology

Have We Hit the Scaling Wall for Protein Language Models? Beyond Scaling: What Truly Works in Protein Fitness Prediction

Even simple methods leveraging these 2 modalities significantly outperform billion-parameter sequence-only models. So, what's next? Better retrieval, advanced multimodal approaches, & alignment. Read more: pascalnotin.substack.com/p/have-we-hi... #BioTech #AI #pLMs

Trashzymes: Mining Municipal solid waste and alkaliphilic species for brilliant cleaning at Procter & Gamble on FindAPhD.com PhD Project - Trashzymes: Mining Municipal solid waste and alkaliphilic species for brilliant cleaning at Procter & Gamble, listed on FindAPhD.com

Please RT, come do a PhD with me as part of an industrial collaboration with P&G using metagenomes and AI to design new enzymes www.findaphd.com/phds/project... #pLMS #AI #enzymes #Bioinformatics