Looking to work with a #postdoc in @dublincityuni.bsky.social on a @researchireland.ie FFP-P funded 4-year position #compchem #DrugDesign #pharmacophore across the pocketome. Please repost. Job advert here: tinyurl.com/3vx6ux2y. @dcu-lsi.bsky.social #ML #cheminformatics #CompChem #ChemJobs #chemsky
A 3D molecular structure visual with colorful spheres and lines represents the concept of a pharmacophore, which highlights the spatial and electronic features of a molecule needed to interact with a receptor and exert biological activity.
Welcome to Wednesday Words, where I will define one word used in biotechnology or biopharma each Wednesday morning!
If you want to learn more, check out: sbee.link/ytqu89bjne
#wednesdaywords #biotechnology #biopharma #Pharmacophore #DrugDiscovery #Pharmacology #science
Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.
Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH
Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.
Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH
Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.
Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH
