A 3D molecular structure visual with colorful spheres and lines represents the concept of a pharmacophore, which highlights the spatial and electronic features of a molecule needed to interact with a receptor and exert biological activity.

Welcome to Wednesday Words, where I will define one word used in biotechnology or biopharma each Wednesday morning!

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#wednesdaywords #biotechnology #biopharma #Pharmacophore #DrugDiscovery #Pharmacology #science

Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.

Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH

Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.

Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH

Proposed mechanism of receptor-dependent activity of bitopic ligands. Structures of PTHR1 and A2AR used in this panel were generated using Alphafold2.

Bitopic ligands comprise a #pharmacophore & a linked moiety that bind to separate sites. @rche54.bsky.social &co show that #GPCRs that bind small molecules can be potently activated by #bitopic #nanobody -ligand conjugates to selectively target pairs of GPCRs @plosbiology.org 🧪 plos.io/4p3VOyH