ApplyPolygenicScore, a new R package, streamlines polygenic score calculation and visualization to empower broader use of genetic risk models beyond statistical genetics. bit.ly/47C1UQA #GIMO #PolygenicRiskModel #PolygenicRiskScore #Cancer #BodyMassIndex

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer's Disease in European Populations: Development and Validation
Akdeniz, B. C., Amer-Ferrer, G. et al.
Paper
Details
#PolygenicRiskScore #AlzheimersDisease #GeneticEpidemiology

Communication is key. Study highlights the importance of having risk communication strategies that consider the specific emotional needs of individuals. bit.ly/45NG2kJ #Breastcancerscreening #Polygenicriskscore #riskcommunication

Prediction of Cardiovascular and Renal Complications of Diabetes by a multi-Polygenic Risk Score in Different Ethnic Groups
Attaoua, R., haloui, M. et al.
Paper
Details
#DiabetesComplications #PolygenicRiskScore #EthnicHealthDisparities

Interplay of #PolygenicRiskScore, #Smoking Statuses, and #AirPollution on Lung #Adenocarcinoma Risk in a Taiwanese Population

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.

#PolygenicRiskScore for Coronary Heart Disease remains an unfulfilled promise of #PrecisionMedicine.

A study of 46 PRSs revealed that the scores only perform similarly at the population level, individual risk predictions vary significantly.

jamanetwork.com/journals/jam...

This interview covers the impact of disclosure of genetic information particularly as it relates to neurological and neuropsychiatric disorders. #neuroscience #neurogenetics #genetictesting #significance #predisposition #polygenicriskscore #diagnosis

Risk loci (HLA & more) for #GiantCellArteritis

GWAS 3498 case + 15550 Ctrl, 10 cohorts/countries

An 11-SNP #PolygenicRiskScore for GCA

rs704, a missense VTN/vitronectin variant
rs8029053 MFGE8▶️#Vasculitis #Amyloidosis?😁

#LancetRheum 2024
www.sciencedirect.com/science/arti...

#PolygenicRiskScore for Familial or Sporadic #SpontaneousCoronaryArteryDissection #SCAD
7 SNVs
PHACTR1
LRP1
LINC00310
C1orf51
NOX3
NBEAL1
HSD52
www.nature.com/articles/s41...

Why there are no Fibrillar Collagen variants in this PRS??🫠

#JAMACardio 2024
jamanetwork.com/journals/jam...