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Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 week ago
Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19 — Azhir et al "We applied multivariable logistic regression with inverse probability weights to infer causal effects" "Overall, Paxlovid did not significantly reduce the risk of PASC across all age groups and organ systems."

Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19 — Azhir et al "We applied multivariable logistic regression with inverse probability weights to infer causal effects" "Overall, Paxlovid did not significantly reduce the risk of PASC across all age groups and organ systems."

Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19

www.nature.com/articles/s43...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

17 4 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL — Kanecia O Zimmerman et al "The RECOVER Viral Persistence and Reactivation, and Immune Dysregulation (RECOVER-VITAL) protocol was the first to be developed, and the workgroup was tasked in August 2022 with creating a platform protocol for evaluation of interventions that might target the proposed underlying etiologies of Long COVID, including viral persistence, immune dysregulation, and altered coagulation."

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL — Kanecia O Zimmerman et al "The RECOVER Viral Persistence and Reactivation, and Immune Dysregulation (RECOVER-VITAL) protocol was the first to be developed, and the workgroup was tasked in August 2022 with creating a platform protocol for evaluation of interventions that might target the proposed underlying etiologies of Long COVID, including viral persistence, immune dysregulation, and altered coagulation."

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL

journals.sagepub.com/doi/abs/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

1 2 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID — Michael J. Peluso et al "no significant differences in physical health, quality of life, objective measures of physical function or cognition, or bloodbased biomarkers were demonstrated between the treatment and control arms."

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID — Michael J. Peluso et al "no significant differences in physical health, quality of life, objective measures of physical function or cognition, or bloodbased biomarkers were demonstrated between the treatment and control arms."

From the US:

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID

www.medrxiv.org/content/10.6...

Screenshot from Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

17 6 4 1
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis — Eiron John Lugtu et al "Although the overall prevalence of post-COVID-19 condition was higher among pre-Omicron infections, the condition continues to exert a sustained burden across variant lineages." "Fatigue consistently emerged as the most long-lasting post-COVID symptom, while distinct symptom patterns were noted"

Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis — Eiron John Lugtu et al "Although the overall prevalence of post-COVID-19 condition was higher among pre-Omicron infections, the condition continues to exert a sustained burden across variant lineages." "Fatigue consistently emerged as the most long-lasting post-COVID symptom, while distinct symptom patterns were noted"

Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis

www.ijidonline.com/article/S120...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

9 3 1 2
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients — Wick et al "we performed live confocal fluorescence microscopy of native, i.e., unfixed, blood samples to detect free-floating cellular aggregates under unperturbed conditions." "we were surprised to find primarily floating globular aggregates that were covered by thrombocytes around a so far undefined core of glyco-rich amorphic material."

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients — Wick et al "we performed live confocal fluorescence microscopy of native, i.e., unfixed, blood samples to detect free-floating cellular aggregates under unperturbed conditions." "we were surprised to find primarily floating globular aggregates that were covered by thrombocytes around a so far undefined core of glyco-rich amorphic material."

From Austria

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients

www.nature.com/articles/s41...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

18 8 1 1
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 — Ray et al "both pro-inflammatory cytokines […] and the anti-inflammatory cytokine IL-10 were reduced in LTCS" "This suggests a dampened cytokine signaling state, rather than the persistent hyperinflammation often assumed" "these stratified comparisons support a model in which LTCS is characterized […] by selective failures in innate–adaptive immune coordination and immune recovery."

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 — Ray et al "both pro-inflammatory cytokines […] and the anti-inflammatory cytokine IL-10 were reduced in LTCS" "This suggests a dampened cytokine signaling state, rather than the persistent hyperinflammation often assumed" "these stratified comparisons support a model in which LTCS is characterized […] by selective failures in innate–adaptive immune coordination and immune recovery."

From Germany

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19

www.frontiersin.org/journals/imm...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

16 10 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis — Park et al "The key function of the subnetwork we identified was the regulation of Ca2+ at the [mitochondria-associated membranes], with particular emphasis on VDAC1, a voltage-dependent anion channel protein that directly participates in mitochondrial Ca2+ transport."

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis — Park et al "The key function of the subnetwork we identified was the regulation of Ca2+ at the [mitochondria-associated membranes], with particular emphasis on VDAC1, a voltage-dependent anion channel protein that directly participates in mitochondrial Ca2+ transport."

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis

dx.doi.org/10.1093/bioa...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

2 1 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
2 weeks ago
News Release 17-Mar-2026 Discovery of a bacterium that protects against long Covid Peer-Reviewed Publication Université catholique de Louvain FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail According to WHO, approximately 6% of the worldwide population who contract Covid-19 – some 400 million people – go on to develop a long-lasting form of the disease. These figures demonstrate that the persistent form of the disease remains a problem and is a major public health challenge. In 2021, in the midst of the Covid-19 pandemic, University of Louvain (UCLouvain, Belgium) and its hospital, the Cliniques universitaires Saint-Luc, launched a large-scale study to determine whether it is possible to predict, during the acute phase of infection, the development of long-term symptoms. The ultimate goal is to better understand the underlying mechanisms and, potentially, develop a preventive therapeutic solution. After five years of research, scientists have discovered the key role played by a bacterium, Dolosigranulum pigrum, that is naturally present in the respiratory microbiome. When present in greater numbers, these bacteria are associated with a reduction in the persistence of symptoms characteristic of long Covid.

News Release 17-Mar-2026 Discovery of a bacterium that protects against long Covid Peer-Reviewed Publication Université catholique de Louvain FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail According to WHO, approximately 6% of the worldwide population who contract Covid-19 – some 400 million people – go on to develop a long-lasting form of the disease. These figures demonstrate that the persistent form of the disease remains a problem and is a major public health challenge. In 2021, in the midst of the Covid-19 pandemic, University of Louvain (UCLouvain, Belgium) and its hospital, the Cliniques universitaires Saint-Luc, launched a large-scale study to determine whether it is possible to predict, during the acute phase of infection, the development of long-term symptoms. The ultimate goal is to better understand the underlying mechanisms and, potentially, develop a preventive therapeutic solution. After five years of research, scientists have discovered the key role played by a bacterium, Dolosigranulum pigrum, that is naturally present in the respiratory microbiome. When present in greater numbers, these bacteria are associated with a reduction in the persistence of symptoms characteristic of long Covid.

News Release 17-Mar-2026

Discovery of a bacterium that protects against long Covid

www.eurekalert.org/news-release...

Full paper (open access)
journals.asm.org/doi/10.1128/...

#COVID19 #LongCovid #COVID #PASC #PwLC #postcovid #postcovid19

37 15 1 2
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID — Man Wang et al "findings support a model in which spike disrupts VLCFA metabolism by binding key lipid metabolic regulators and sequestering [linoleic acid], thereby suppressing PPAR-peroxisome signaling, impairing [enterocyte] differentiation and epithelial regeneration, and contributing to persistent GI symptoms."

Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID — Man Wang et al "findings support a model in which spike disrupts VLCFA metabolism by binding key lipid metabolic regulators and sequestering [linoleic acid], thereby suppressing PPAR-peroxisome signaling, impairing [enterocyte] differentiation and epithelial regeneration, and contributing to persistent GI symptoms."

From China

Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID

www.cell.com/developmenta...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

6 2 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies — Salim Abraham Soria et al "We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested." "comparison of Spike-positive regions in LC versus healthy control colon tissues revealed a differential, symptomatic state-associated signature, with 57 differentially expressed genes"

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies — Salim Abraham Soria et al "We confirmed the persistence of SARS-CoV-2 Spike transcript and protein in the gut tissue of all LC cases and controls tested." "comparison of Spike-positive regions in LC versus healthy control colon tissues revealed a differential, symptomatic state-associated signature, with 57 differentially expressed genes"

From the US

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies

www.biorxiv.org/content/10.6...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

9 2 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
USA - RECOVER Initiative (NIH) Honoring the many lived experiences with Long COVID The article starts with a mention of International Long COVID Awareness Day, March 15. It then lists some of the ways that Long Covid patients have "contributed their time, perspectives, and health information" to the RECOVER initiative research.

USA - RECOVER Initiative (NIH) Honoring the many lived experiences with Long COVID The article starts with a mention of International Long COVID Awareness Day, March 15. It then lists some of the ways that Long Covid patients have "contributed their time, perspectives, and health information" to the RECOVER initiative research.

RECOVER Initiative (NIH): Honoring the many lived experiences with Long COVID

recovercovid.org/news/honorin...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

15 4 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers — Taizen Nakase et al. "In our study, imbalanced activity of the occipital lobe between the right and left hemispheres was associated with cognitive dysfunction. Reduced activity in the right parietal lobe is correlated with psychological symptoms."

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers — Taizen Nakase et al. "In our study, imbalanced activity of the occipital lobe between the right and left hemispheres was associated with cognitive dysfunction. Reduced activity in the right parietal lobe is correlated with psychological symptoms."

From Japan

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers

www.jns-journal.com/article/S002...

Screenshot from Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #COVIDBrain #NeuroPASC

6 3 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago

From Norway:

Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study

www.nature.com/articles/s41...

Screenshot from Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #postcovid #postcovid19

9 1 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
‘What Do People With Long Covid Want From Healthcare Services?’ A Qualitative Exploration From Lived Experience — Clare Rayner et al. "Patients emphasised the importance of being heard and the value of receiving timely care that reflects the latest scientific understanding and recognises their condition as real, treatable and deserving of ongoing clinical attention."

‘What Do People With Long Covid Want From Healthcare Services?’ A Qualitative Exploration From Lived Experience — Clare Rayner et al. "Patients emphasised the importance of being heard and the value of receiving timely care that reflects the latest scientific understanding and recognises their condition as real, treatable and deserving of ongoing clinical attention."

From the UK

‘What Do People With Long Covid Want From Healthcare Services?’ A Qualitative Exploration From Lived Experience

onlinelibrary.wiley.com/doi/10.1111/...

Screenshot from Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

15 2 2 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
News Release 12-Mar-2026 Trial finds vitamin D supplements don’t reduce covid severity but could reduce long COVID risk Peer-Reviewed Publication Mass General Brigham FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Mass General Brigham study results signal a call to do further research into the connection between vitamin D supplementation and long COVID In a large, randomized trial, researchers at Mass General Brigham have found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Results of the study are published in The Journal of Nutrition. “There’s been tremendous interest in whether vitamin D supplements can be of benefit in COVID, and this is one of the largest and most rigorous randomized trials on the subject,” said senior author JoAnn Manson, MD, DrPH, of the Mass General Brigham Department of Medicine. “While we didn’t find that high-dose vitamin D reduced COVID severity or hospitalizations, we observed a promising signal for long COVID that merits additional research.”

News Release 12-Mar-2026 Trial finds vitamin D supplements don’t reduce covid severity but could reduce long COVID risk Peer-Reviewed Publication Mass General Brigham FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Mass General Brigham study results signal a call to do further research into the connection between vitamin D supplementation and long COVID In a large, randomized trial, researchers at Mass General Brigham have found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Results of the study are published in The Journal of Nutrition. “There’s been tremendous interest in whether vitamin D supplements can be of benefit in COVID, and this is one of the largest and most rigorous randomized trials on the subject,” said senior author JoAnn Manson, MD, DrPH, of the Mass General Brigham Department of Medicine. “While we didn’t find that high-dose vitamin D reduced COVID severity or hospitalizations, we observed a promising signal for long COVID that merits additional research.”

News Release 12-Mar-2026

Trial finds vitamin D supplements don’t reduce covid severity but could reduce long COVID risk

www.eurekalert.org/news-release...

Paper:
jn.nutrition.org/article/S002...

#LongCovid #PASC #COVID19 #COVID #novid #postcovid #postcovid19

12 5 2 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
3 weeks ago
March is Long COVID Awareness Month Long COVID Awareness Month logo Long COVID Awareness Month is a time for everyone impacted by Long COVID to come together globally in coordinated awareness and action. This effort will highlight the urgent need for prevention, research, funding, and long-term care for people suffering with Long COVID. Hundreds of millions worldwide continue to be infected with SARS-CoV-2, and many are still developing Long COVID. The World Health Organization estimates 10–20% of those infected experience prolonged symptoms. COVID-19 Longhauler Advocacy Project (C19LAP) has created a calendar of events to particpate, with many activities you can do from home.

March is Long COVID Awareness Month Long COVID Awareness Month logo Long COVID Awareness Month is a time for everyone impacted by Long COVID to come together globally in coordinated awareness and action. This effort will highlight the urgent need for prevention, research, funding, and long-term care for people suffering with Long COVID. Hundreds of millions worldwide continue to be infected with SARS-CoV-2, and many are still developing Long COVID. The World Health Organization estimates 10–20% of those infected experience prolonged symptoms. COVID-19 Longhauler Advocacy Project (C19LAP) has created a calendar of events to particpate, with many activities you can do from home.

March is Long COVID Awareness Month

Links:
www.longhauler-advocacy.org
www.longhauler-advocacy.org/lcamonth2026

Screenshot from Massachusetts ME/CFS & FM Association March 2026 Newsletter
massmecfs.org/resources/ne...

#LongCovid #PASC #PwLC #postcovid #postcovid19 @c19lap.bsky.social

17 9 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
4 weeks ago
Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction — Zameer et al. "Our study shows that SARS-CoV-2 infection is associated with widespread, severity-specific epigenetic changes in peripheral blood, with minimal overlap in differentially methylated regions and genes among mild, moderate, and severe cases."

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction — Zameer et al. "Our study shows that SARS-CoV-2 infection is associated with widespread, severity-specific epigenetic changes in peripheral blood, with minimal overlap in differentially methylated regions and genes among mild, moderate, and severe cases."

From USA

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction

link.springer.com/article/10.1...

Screenshot from Science for ME weekly update

#LongCovid #NeuroPASC #PASC #PwLC #postcovid #postcovid19

5 6 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
4 weeks ago
10 March 2026 Chronic fatigue over chronic fatigue reform 4 minute read Chronic Disease Political By Euan Kielly A parliament hearing has heard from ME/CFS advocates on where and how healthcare needs to step up to address the under-recognised field. Long covid was the focus for lawmakers, clinicians, researchers and people with lived experience at today’s annual parliamentary friends of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) gathering.

10 March 2026 Chronic fatigue over chronic fatigue reform 4 minute read Chronic Disease Political By Euan Kielly A parliament hearing has heard from ME/CFS advocates on where and how healthcare needs to step up to address the under-recognised field. Long covid was the focus for lawmakers, clinicians, researchers and people with lived experience at today’s annual parliamentary friends of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) gathering.

(Australia)
"Long covid was the focus for lawmakers, clinicians, researchers and people with lived experience at today’s annual parliamentary friends of ME/CFS gathering."

www.medicalrepublic.com.au/chronic-fati...

Sympathetic article

#LongCovid #PASC #PwLC #postcovid #postcovid19 #auscovid19

8 2 0 2
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
4 weeks ago
Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection — Fineschi et al. "our extended proteomic analysis shows that key proinflammatory cytokines characterizing the acute phase of SARS-CoV-2 infection remain dysregulated in individuals with PASC, even long after the initial infection." "This persistent immune perturbation suggests a failure of proper immune resolution that may not require detectable viral persistence in plasma"

Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection — Fineschi et al. "our extended proteomic analysis shows that key proinflammatory cytokines characterizing the acute phase of SARS-CoV-2 infection remain dysregulated in individuals with PASC, even long after the initial infection." "This persistent immune perturbation suggests a failure of proper immune resolution that may not require detectable viral persistence in plasma"

From Sweden

Plasma proteomic profile reveals persistent immune activation in post-acute sequelae of SARS-CoV-2 infection

www.frontiersin.org/journals/imm...

Screenshot from Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

16 6 1 1
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
4 weeks ago
Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI — MacIntosh et al. "The findings revealed a pattern of lower rCBV in the PCC group relative to controls in ROIs that have previously been reported in analogous structural and perfusion neuroimaging studies."

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI — MacIntosh et al. "The findings revealed a pattern of lower rCBV in the PCC group relative to controls in ROIs that have previously been reported in analogous structural and perfusion neuroimaging studies."

From Canada:

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI

www.frontiersin.org/journals/neu...

Screenshot from Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

15 6 0 0
TRAstonDrs
TRAstonDrs
@castltrastondrs.bsky.social
4 weeks ago

#Medsky🧪 #IDsky #pedsky #publichealth In the #postCOVID19 era, respiratory co-infections in patients with #influenza-like illness (ILI) are characterized by a high prevalence of multi pathogen interactions,

3 1 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago

Oops, I used the wrong screenshot with this.
Here is the correct one for "Progressively Widening Healthcare Costs in Long COVID Over Five Years"

www.medrxiv.org/content/10.6...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

6 2 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago

Symptom Patterns, Recovery, and Impact of Long COVID: Findings From a Longitudinal Survey

dx.doi.org/10.1093/ofid...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

11 4 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID— Felix S. Seibert et al. "Although certain autoantibodies were associated with parameters of vasoregulation, the present data do not provide evidence for a causal, pathogenic, or etiologically relevant role of these autoantibodies in Post-COVID."

Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID— Felix S. Seibert et al. "Although certain autoantibodies were associated with parameters of vasoregulation, the present data do not provide evidence for a causal, pathogenic, or etiologically relevant role of these autoantibodies in Post-COVID."

From Germany

Association of G-Protein-Coupled Receptors autoantibodies with vasoregulation in Post-COVID

journals.plos.org/plosone/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

3 1 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
Exploratory analyses of Immunologic Features in a Randomized, Placebo-Controlled Trial of Nirmatrelvir/Ritonavir for Long COVID — Bornali Bhattacharjee et al. "no virological or immunological evidence supports [Paxlovid] as a treatment for Long COVID." "Decreased RANTES levels were associated with symptom improvement, independent of treatment, age, sex, or vaccine status"

Exploratory analyses of Immunologic Features in a Randomized, Placebo-Controlled Trial of Nirmatrelvir/Ritonavir for Long COVID — Bornali Bhattacharjee et al. "no virological or immunological evidence supports [Paxlovid] as a treatment for Long COVID." "Decreased RANTES levels were associated with symptom improvement, independent of treatment, age, sex, or vaccine status"

From a randomised, placebo-controlled trial of Nirmatrelvir/Ritonavir:
"no virological or immunological evidence supports [Paxlovid] as a treatment for Long COVID."

www.medrxiv.org/content/10.6...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

21 4 1 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
News Release 2-Mar-2026 Study identifies molecular cause of taste loss after COVID Research links persistent loss of sweet, bitter and umami taste to reduced levels of key taste-cell protein Peer-Reviewed Publication University of Colorado Anschutz FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail AURORA, Colo. (Jan. 29, 2026) – Scientists have identified molecular and structural changes in taste buds that may explain why a small subset of people experience long-term taste loss after COVID-19 infection. The study, published last month in Chemical Senses, provides the first direct evidence linking patients’ reported taste changes to measurable biological abnormalities inside taste cells. What causes long-term taste loss after COVID-19? Researchers from the University of Colorado Anschutz and two Swedish universities studied 28 non-hospitalized patients who reported persistent taste disturbances more than one year after contracting COVID-19.

News Release 2-Mar-2026 Study identifies molecular cause of taste loss after COVID Research links persistent loss of sweet, bitter and umami taste to reduced levels of key taste-cell protein Peer-Reviewed Publication University of Colorado Anschutz FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail AURORA, Colo. (Jan. 29, 2026) – Scientists have identified molecular and structural changes in taste buds that may explain why a small subset of people experience long-term taste loss after COVID-19 infection. The study, published last month in Chemical Senses, provides the first direct evidence linking patients’ reported taste changes to measurable biological abnormalities inside taste cells. What causes long-term taste loss after COVID-19? Researchers from the University of Colorado Anschutz and two Swedish universities studied 28 non-hospitalized patients who reported persistent taste disturbances more than one year after contracting COVID-19.

News Release 2-Mar-2026
"Study identifies molecular cause of taste loss after COVID"

"Research links persistent loss of sweet, bitter and umami taste to reduced levels of key taste-cell protein"

www.eurekalert.org/news-release...

#LongCovid #PASC #PwLC #postcovid #postcovid19

20 9 0 3
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
Med Sci (Paris) "Covid long : une longue histoire" This French article by Ilana Löwy in medicine/science argues that Long Covid patients are confronted with an "epistemological injustice": a lack of recognition of their suffering. Because of an absence of objective signs of a recognized disease some health professionals incorrectly consider it to be a psychosomatic condition.

Med Sci (Paris) "Covid long : une longue histoire" This French article by Ilana Löwy in medicine/science argues that Long Covid patients are confronted with an "epistemological injustice": a lack of recognition of their suffering. Because of an absence of objective signs of a recognized disease some health professionals incorrectly consider it to be a psychosomatic condition.

Med Sci (Paris) "Covid long : une longue histoire"

French version:
www.medecinesciences.org/fr/articles/...

Google English translation
www-medecinesciences-org.translate.goog/fr/articles/...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #MEcfs #postcovid #postcovid19

8 2 0 0
Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
Bloomberg How Covid Quietly Rewires the Brain An adapted article based in an upcoming book "After Covid: The Health Impacts That Will Last Generations" by Jason Gale. Avindra Nath talks of his research into Covid and Long Covid. Nath says it has not been surprising to see overlap in symptoms with ME/CFS. Article (Paywalled) l Thread

Bloomberg How Covid Quietly Rewires the Brain An adapted article based in an upcoming book "After Covid: The Health Impacts That Will Last Generations" by Jason Gale. Avindra Nath talks of his research into Covid and Long Covid. Nath says it has not been surprising to see overlap in symptoms with ME/CFS. Article (Paywalled) l Thread

How Covid Quietly Rewires the Brain

www.bloomberg.com/news/feature...

archive.md/FYsGV

Screenshot from latest Science for ME weekly update

#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

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Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago

R3 Seminar Recap: Long COVID trajectories in adults

5-minutes text summary plus also link to video on paper by members of the research team

recovercovid.org/r3-seminar-s...

#LongCovid #PASC #COVID19 #COVID #PASC #PwLC #postcovid #postcovid19

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Tom Kindlon
Tom Kindlon
@tomkindlon.bsky.social
1 month ago
Early administration of neutralizing monoclonal antibodies and post-acute sequelae of COVID-19 — Jinghao Nicholas Ngiam et al. "In our cohort, we found that early treatment with mAbs did not significantly alter the overall risk of PASC." "We observed that patients who received mAbs had a higher risk of developing post-acute autoimmune sequelae (adjusted HR [aHR] = 2.20 [1.22, 3.97])"

Early administration of neutralizing monoclonal antibodies and post-acute sequelae of COVID-19 — Jinghao Nicholas Ngiam et al. "In our cohort, we found that early treatment with mAbs did not significantly alter the overall risk of PASC." "We observed that patients who received mAbs had a higher risk of developing post-acute autoimmune sequelae (adjusted HR [aHR] = 2.20 [1.22, 3.97])"

From Singapore

Early administration of neutralizing monoclonal antibodies and post-acute sequelae of COVID-19

www.ijidonline.com/article/S120...

Screenshot from latest Science for ME weekly update

#LongCovid #Covid #PASC #PwLC #postcovid #postcovid19

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