Cognitive and Neuropsychiatric Sequelae After SARS-CoV-2 Infection: A Narrative Review and Exploratory Cross-Sectional Study of Neurofilament Light Chain and GFAP — Crystell Guadalupe Guzmán Priego et al "Nearly two years after infection, plasma NfL and GFAP concentrations did not differ between severity groups, indicating no detectable ongoing axonal or astrocytic injury at the group level."

Cognitive and Neuropsychiatric Sequelae After SARS-CoV-2 Infection: A Narrative Review and Exploratory Cross-Sectional Study of Neurofilament Light Chain and GFAP

www.mdpi.com/2076-3425/16...

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#LongCovid #COVIDBrain #NeuroPASC

Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies — Chen et al "We identified 49 articles meeting the inclusion criteria." "We comprehensively summarized COVID-19 associated microstructural and functional alterations, categorized by imaging modality."

Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies

dx.doi.org/10.1093/cerc...

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#LongCovid #COVIDBrain #NeuroPASC

Intravenous immunoglobulin treatment for long COVID: a case report of clinical and immunological findings A previously healthy 39-year-old man developed highly symptomatic post-COVID-19 condition (also known as long COVID) marked by cognitive dysfunction, disabling fatigue, and autonomic symptoms unrespon...

New #LongCovid case report:

“This patient provides exploratory evidence that high-dose intravenous immunoglobulin was associated with sustained clinical recovery from long COVID over 1 year of follow-up, accompanied by immunological changes…”

www.thelancet.com/journals/lan...

#NeuroPASC #IVIG

Autoantibody landscapes in neurological Long COVID and post-COVID cognitive impairment show heterogeneity without a shared disease signature — Debanjana Chakravarty et al "Across tissue-based assays and peptide-level, whole-human-proteome PhIP-Seq profiling, the data consistently reveal a lack of convergent, disease-specific autoantibody signatures."

From the US

Autoantibody landscapes in neurological Long COVID and post-COVID cognitive impairment show heterogeneity without a shared disease signature

www.medrxiv.org/content/10.6...

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#LongCovid #COVIDBrain #NeuroPASC

Frontiers | Severe alcohol use and COVID-19: implications for physical and mental health The COVID-19 pandemic has revealed and intensified the vulnerability of individuals with pre-existing medical and behavioral conditions, notably those relate...

-Cognitive impairment & executive dysfunction
-Depression & anxiety in #neuroPASC ( #longCOVID)
- Anxiety and PTSD symptoms at 6‑month follow‑up
- Persistent inflammation 2 years post‑infection
www.frontiersin.org/journals/psy...

www.sciencedirect.com/science/arti...

Increased incidence of mild cognitive impairment in long COVID patients — Jennifer A. Frontera et al. "Using National Alzheimer’s Coordinating Center (NACC) and National Institute on Aging (NIA) - Alzheimer’s Association criteria we found a significantly increased cumulative incidence and hazard of MCI (and specifically AD subtype of MCI) in Long-COVID patients, compared to recovered-COVID and COVID-negative controls."

From the US

Increased incidence of mild cognitive impairment in long COVID patients

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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#LongCovid #NeuroPASC #COVIDBrain #novid #COVID19 #COVID

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID — Matheus Aranguren et al. "Transfer of LC-associated microbiota into germ-free mice recapitulated features of intestinal barrier dysfunction, systemic inflammation, and neuroinflammation, with effects most pronounced in mice colonized with microbiota from individuals with neurological symptoms."

From Canada

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID

www.biorxiv.org/content/10.6...

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#LongCovid #NeuroPASC

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers — Taizen Nakase et al. "In our study, imbalanced activity of the occipital lobe between the right and left hemispheres was associated with cognitive dysfunction. Reduced activity in the right parietal lobe is correlated with psychological symptoms."

From Japan

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers

www.jns-journal.com/article/S002...

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#LongCovid #PASC #PwLC #postcovid #postcovid19 #COVIDBrain #NeuroPASC

From Norway:

Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation–a controlled study

www.nature.com/articles/s41...

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#LongCovid #NeuroPASC #COVIDBrain #postcovid #postcovid19

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction — Zameer et al. "Our study shows that SARS-CoV-2 infection is associated with widespread, severity-specific epigenetic changes in peripheral blood, with minimal overlap in differentially methylated regions and genes among mild, moderate, and severe cases."

From USA

Genome-wide DNA methylation profiling in COVID-19 positive patients reveals alterations in pathways linked to neurological dysfunction

link.springer.com/article/10.1...

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#LongCovid #NeuroPASC #PASC #PwLC #postcovid #postcovid19

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI — MacIntosh et al. "The findings revealed a pattern of lower rCBV in the PCC group relative to controls in ROIs that have previously been reported in analogous structural and perfusion neuroimaging studies."

From Canada:

Post COVID-19 condition is associated with altered regional cerebral blood volume as revealed by dynamic susceptibility contrast MRI

www.frontiersin.org/journals/neu...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Image of a brain Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study "The changes in lactate in ME/CFS are consistent with the presence of energetic stress and mitochondrial dysfunction. A reduction in total choline in long COVID is of interest in the context of the recently reported association between blood clots and 'brain fog', and earlier animal studies showing that choline might prevent intravascular coagulation. Importantly, differences in findings between ME/CFS and long COVID suggest that the underlying neurobiological mechanisms, while leading to similar clinical presentations, may differ." Read more here>>

UK research study

Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study

www.nature.com/articles/s41...

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#MEcfs #LongCovid #CFS #PwME #COVIDBrain #NeuroPASC

News Release 5-Mar-2026 How viruses mess with our brains A team from the UNIGE and the HUG reviewed 900 scientific articles to better understand the impact of viruses on memory, attention, and concentration. Peer-Reviewed Publication Université de Genève FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail What impact does a viral infection have on our memory, attention, and concentration? The COVID-19 pandemic has reignited interest in this question, which has now been extended to other infections such as HIV, herpes, and hepatitis. A team from the University of Geneva (UNIGE) and Geneva University Hospital (HUG) reviewed over 900 scientific articles exploring the links between the immune system and cognitive functions. This analysis, published in Neuroscience & Biobehavioral Reviews, has identified several biological markers associated with cognitive decline in the context of infection. It also provides a solid foundation for future research.

News Release 5-Mar-2026

"How viruses mess with our brains: A team from the UNIGE and the HUG reviewed 900 scientific articles to better understand the impact of viruses on memory, attention, and concentration"

www.eurekalert.org/news-release...

#COVIDBrain #NeuroPASC #LongCovid #PASC #MEcfs #CFS

Bloomberg How Covid Quietly Rewires the Brain An adapted article based in an upcoming book "After Covid: The Health Impacts That Will Last Generations" by Jason Gale. Avindra Nath talks of his research into Covid and Long Covid. Nath says it has not been surprising to see overlap in symptoms with ME/CFS. Article (Paywalled) l Thread

How Covid Quietly Rewires the Brain

www.bloomberg.com/news/feature...

archive.md/FYsGV

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Northwestern study explores long COVID symptoms across countries An international study led by Northwestern Medicine found that patients with long COVID-19 in countries such as the U.S. and Colombia were more likely to report neurological symptoms, including brain ...

Northwestern study explores long COVID symptoms across countries (Colombia, Nigeria, the US, India)

dailynorthwestern.com/2026/02/26/c...

Not excited by the intensive cognitive rehabilitation programs mentioned at the end. Not likely suitable for those with PEM

#longcovid #NeuroPASC #CovidBrain

Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome — Kutz et al. "PCS patients displayed disturbed intermittency in blood flow regulation as indicated by a more rigid blood flow signal structure particularly during the N-back task, which targets working memory and sustained attention."

Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome

dx.doi.org/10.1093/brai...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

News Release 25-Feb-2026 Tulane study reveals key differences in long-term brain effects of COVID-19 and flu Disruption of serotonin and dopamine signaling pathways could explain why some feel 'brain fog' after being infected by COVID-19 Peer-Reviewed Publication Tulane University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail Even a mild case of COVID-19 or the flu can impact the body long after the fever and cough fade, according to new Tulane University research that may help explain why some people struggle to feel fully recovered weeks or months later. Tulane researchers found that while both viruses can leave lasting lung damage, only SARS-CoV-2 infection caused persistent brain inflammation and small blood vessel injury, even after the virus was no longer detectable. The findings, published in Frontiers in Immunology, help explain why long COVID often includes neurological symptoms such as brain fog, fatigue and mood changes, while influenza is more commonly associated with respiratory complications.

News Release 25-Feb-2026

"Tulane study reveals key differences in long-term brain effects of COVID-19 and flu: Disruption of serotonin & dopamine signaling pathways could explain why some feel 'brain fog' after being infected by COVID-19"

www.eurekalert.org/news-release...

#LongCovid #NeuroPASC

Austria The Long Covid outpatient clinic planned at the psychiatric department of Vienna General Hospital will not be approved, the hospital announced. There has been strong criticism from experts of the proposed treatment concept, which was seen as equating Long Covid too closely with depression.

The Long Covid outpatient clinic planned at the psychiatric department of Vienna General Hospital will not be approved

Google English translation
wien-orf-at.translate.goog/stories/3342...

wien.orf.at/stories/3342...

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#LongCovid #NeuroPASC

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome — Martins et al. "this study demonstrates that PCS is associated with regionally specific alterations in cerebral perfusion and oxygen metabolism. These findings support a dual process model in which hippocampal hypermetabolism seems to reflect compensatory adaptation, while ACC neurovascular uncoupling might derive from neuroimmune disruption." "findings identify the ACC as a metabolically vulnerable hub in PCS"

From 🇬🇧

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome

www.sciencedirect.com/science/arti...

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#LongCovid #NeuroPASC #COVIDBrain #postcovid19

Circulating mitochondrial and cellular damage markers in long COVID: Links to cognitive function, psychological distress, and inflammation - Molecular Psychiatry Molecular Psychiatry - Circulating mitochondrial and cellular damage markers in long COVID: Links to cognitive function, psychological distress, and inflammation

🇩🇪

Circulating mitochondrial and cellular damage markersin long COVID: Links to cognitive function, psychological distress, and inflammation

www.nature.com/articles/s41...

"general cognition correlated positively with the relative [circulating cell-free mitochondrial DNA]"

#longCovid #NeuroPASC

Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis - Scientific Reports Scientific Reports - Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis

Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis

www.nature.com/articles/s41...

"widespread nature of LCov connectivity abnormalities supports a hypothesis #longCOVID derives from brain-wide deficits”

#NeuroPASC #CovidBrain

From the US:

Choroid plexus alterations in long COVID and their associations with Alzheimer's disease risks

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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#LongCovid #PASC #PwLC #postcovid #postcovid19 #COVIDBrain #NeuroPASC

News Release 10-Feb-2026 Long COVID linked to Alzheimer’s disease mechanisms Diseases cause damage in some of the same ways Peer-Reviewed Publication NYU Langone Health / NYU Grossman School of Medicine FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail The increased size of, and lesser blood supply to, a key brain structure in patients with Long COVID tracks with known blood markers of Alzheimer’s disease and greater levels of dementia, a new study finds. Led by NYU Langone Health researchers, the study concerns the choroid plexus (CP), a network of blood vessels lined by cells that produce cerebrospinal fluid, which cushions the brain and forms a protective barrier between the fluid and the bloodstream. The CP regulates immune system responses (inflammation) and waste clearance in the brain. Past studies show that the COVID-19 virus can damage the cells lining CP blood vessels. Published online Feb. 10 in Alzheimer's & Dementia, the new work found that patients reporting Long COVID had a 10% larger CP than those who had fully recovered from an initial infection with SARS-CoV-2, the virus that causes COVID-19 disease. Further, CP size increases tracked with blood levels of proteins that increase as Alzheimer’s disease worsens, such as pTau217, and with blood levels of others that rise in response to brain injury, like glial fibrillary acidic protein.

News Release 10-Feb-2026
"Long COVID linked to Alzheimer’s disease mechanisms: Diseases cause damage in some of the same ways"

www.eurekalert.org/news-release...

New US research.

Full paper:
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#LongCovid #COVIDBrain #NeuroPASC #postcovid

The Stigma of self-report in health research: Time to reconsider what counts as “Objective” — Nisreen A. Alwan "The assumption is that people misremember, exaggerate, or misinterpret their symptoms. But what if the problem lies not in the type of data, but in our unwillingness to trust this mode of reporting without adequate justification for such mistrust?"

The Stigma of self-report in health research: Time to reconsider what counts as “Objective” by Nisreen A. Alwan @nisreenalwan.bsky.social

journals.plos.org/globalpublic...

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#LongCovid #NeuroPASC

Healthcare Consumption and Work Absenteeism of Individuals With and Without Persistent Complaints After COVID-19: The Role of Cognitive-Behavioural Factors, Neuropsychological Functioning and Depressive Symptoms — Verveen et al. "the relationship between reporting persisting symptoms and increased healthcare consumption could not be explained by cognitive-behavioural factors, depressive symptoms or neuropsychological functioning."

"the relationship between reporting persisting symptoms & increased healthcare consumption could not be explained by cognitive-behavioural factors, depressive symptoms or neuropsychological functioning."

link.springer.com/article/10.1...

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#LongCovid #NeuroPASC

A cross-continental comparative analysis of the neurological manifestations of Long COVID — Jimenez et al. "This study found that overall, cognitive and sleep disorders, headache and dizziness were the most frequent neurologic symptoms as well as fatigue." "Neuro-PASC affects young and middle-aged adults in their prime, causing significant detrimental impact on the workforce, productivity and innovation all over the world."

A cross-continental comparative analysis of the neurological manifestations of Long COVID

www.frontiersin.org/journals/hum...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Episodic memory deficits and processes in post-COVID condition — Oliver-Mas et al. "the LASSI-L showed the highest correlation with the subjective cognitive complaints questionnaire." "This is consistent with the fact that LASSI-L is examining learning and recall during the effects of proactive and retroactive interference, and such interference in memory is likely to occur in daily living."

From Spain:

Episodic memory deficits and processes in post-COVID condition

link.springer.com/article/10.1...

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#LongCovid #NeuroPASC #COVIDBrain #PASC #PwLC #postcovid #postcovid19

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone — Otsuka et al. "Although the peak responses were preserved across the axes, we observed consistent patterns of delayed peaks and sustained elevation at 120 min, especially in the responses of gonadotropins, PRL, and TSH." "the peak ACTH and cortisol responses to CRH and their recovery levels at 120 min were nearly normal, failing to detect clear HPA axis abnormalities."

Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone

www.mdpi.com/1422-0067/27...

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#LongCovid #NeuroPASC #PASC #PwLC #postcovid #postcovid19 #COVIDBrain

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome — Martins et al. "this study demonstrates that PCS is associated with regionally specific alterations in cerebral perfusion and oxygen metabolism. These findings support a dual process model in which hippocampal hypermetabolism seems to reflect compensatory adaptation, while ACC neurovascular uncoupling might derive from neuroimmune disruption." "findings identify the ACC as a metabolically vulnerable hub in PCS"

From the UK

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion & oxygen metabolism in Post-COVID-19 Syndrome

www.biorxiv.org/content/10.6...

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#LongCovid #NeuroPASC #COVIDBrain #postcovid #postcovid19

Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy — Weber-Fahr et al. "Our 31P MRSI findings provide robust in vivo evidence for impaired cellular energy metabolism in the brains of patients with PCCo." "lower ATP/PCr ratios in the ACC correlated with poorer performance on neurocognitive tests, suggesting a direct link between metabolic dysfunction in this key brain region and cognitive impairment in PCCo patients."

From Germany:

Reduced ATP-to-phosphocreatine ratios in neuropsychiatric post-COVID condition: Evidence from 31P magnetic resonance spectroscopy

www.sciencedirect.com/science/arti...

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#LongCovid #NeuroPASC #COVIDBrain #postcovid #postcovid19