ME/CFS and Long COVID: New Severity Biomarkers Found

Study: Proteomic signatures in cerebrospinal fluid and their clinical associations in patients with ME/CFS

#MECFS #LongCovid #PostCovidSyndrome

www.nature.com/articles/s41...

Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19 — Azhir et al "We applied multivariable logistic regression with inverse probability weights to infer causal effects" "Overall, Paxlovid did not significantly reduce the risk of PASC across all age groups and organ systems."

Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19

www.nature.com/articles/s43...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Heart Rate vs Quality of Life: New Data Challenge the Standard Approach to Long COVID POTS | Pharmacy Times The RECOVER-AUTONOMIC trial underscores the necessity of better clinical end points to assess interventions in the long COVID population.

CLINICAL TRIAL: Treatment of PoTS (Postural orthostatic tachycardia syndrome) in Long Covid with ivabradine.

www.pharmacytimes.com/view/heart-rate-vs-quali...

#MECFS #pwME #POTS #LongCovid #PostCovidSyndrome

“It felt like a life-or-death choice”: Pregnancy with Long COVID has many unknowns - The Sick Times Little is known so far about how people with Long COVID experience pregnancy, but some insights can be gleaned from myalgic encephalomyelitis (ME) as well as several ongoing studies in this area.

**Trigger Warning - contains upsetting content**

The Sick Times: “It felt like a life-or-death choice”: Pregnancy with Long COVID has many unknowns

https://tinyurl.com/mwxrm24v 

#LongCovid #PostCovidSyndrome #Pregnancy #Fertility #MECFS

Bradford man says long Covid sufferers have been 'abandoned' Darren Parkinson from Bradford got Covid in 2021 and five years later struggles to leave the house.

BBC News: 'Long Covid sufferers have been abandoned and forgotten about' 

Read more: https://www.bbc.co.uk/news/articles/cvg3lmxm04po 

#LongCovid #PostCovid #PostCovidSyndrome

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL — Kanecia O Zimmerman et al "The RECOVER Viral Persistence and Reactivation, and Immune Dysregulation (RECOVER-VITAL) protocol was the first to be developed, and the workgroup was tasked in August 2022 with creating a platform protocol for evaluation of interventions that might target the proposed underlying etiologies of Long COVID, including viral persistence, immune dysregulation, and altered coagulation."

Developing a platform protocol for clinical trials evaluating interventions that target proposed mechanisms of Long COVID: RECOVER-VITAL

journals.sagepub.com/doi/abs/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID — Michael J. Peluso et al "no significant differences in physical health, quality of life, objective measures of physical function or cognition, or bloodbased biomarkers were demonstrated between the treatment and control arms."

From the US:

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID

www.medrxiv.org/content/10.6...

Screenshot from Science for ME weekly update

#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis — Eiron John Lugtu et al "Although the overall prevalence of post-COVID-19 condition was higher among pre-Omicron infections, the condition continues to exert a sustained burden across variant lineages." "Fatigue consistently emerged as the most long-lasting post-COVID symptom, while distinct symptom patterns were noted"

Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis

www.ijidonline.com/article/S120...

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#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients — Wick et al "we performed live confocal fluorescence microscopy of native, i.e., unfixed, blood samples to detect free-floating cellular aggregates under unperturbed conditions." "we were surprised to find primarily floating globular aggregates that were covered by thrombocytes around a so far undefined core of glyco-rich amorphic material."

From Austria

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients

www.nature.com/articles/s41...

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#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19 — Ray et al "both pro-inflammatory cytokines […] and the anti-inflammatory cytokine IL-10 were reduced in LTCS" "This suggests a dampened cytokine signaling state, rather than the persistent hyperinflammation often assumed" "these stratified comparisons support a model in which LTCS is characterized […] by selective failures in innate–adaptive immune coordination and immune recovery."

From Germany

Dysregulated NK-cell gene expression defines the enduring symptoms of long COVID-19

www.frontiersin.org/journals/imm...

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#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis — Park et al "The key function of the subnetwork we identified was the regulation of Ca2+ at the [mitochondria-associated membranes], with particular emphasis on VDAC1, a voltage-dependent anion channel protein that directly participates in mitochondrial Ca2+ transport."

Advancing understanding of long COVID pathophysiology through quantum walk-based network analysis

dx.doi.org/10.1093/bioa...

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#LongCovid #PASC #postcovid #postcovid19 #PostCovidSyndrome

Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID — Man Wang et al "findings support a model in which spike disrupts VLCFA metabolism by binding key lipid metabolic regulators and sequestering [linoleic acid], thereby suppressing PPAR-peroxisome signaling, impairing [enterocyte] differentiation and epithelial regeneration, and contributing to persistent GI symptoms."

From China

Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID

www.cell.com/developmenta...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

#COVID #LongCovid #PostCovidSyndrome

England Closes Several Long COVID Clinics, Deserting Patients  | Think Global Health The closures mark a funding reversal by the National Health Service and come even as Long COVID's prevalence remains steady

Think Global Health: England Closes Several Long COVID Clinics, Deserting Patients 

The MEA helped provide a lot of background information for this article, and would like to thank the journalist, Emma Smith.

Read more: https://tinyurl.com/2pd37259

#LongCovid #PostCovidSyndrome

Teenager calls for better support for young people suffering with Long Covid A TEENAGER from Weymouth is calling on MPs to take more action over supporting children and young people with Long Covid as a new campaign gathers…

Dorset Echo: New Long Covid Kids campaign calls on MPs to take action

Read more: www.dorsetecho.co.uk/news/25933330.new-long-c...

#LongCovid #PostCovidSyndrome #LongCovidKids

The study investigated the potential persistence of #SARSCoV2 nucleocapsid (N) protein & characterized the local immune activity within the gut-associated lymphoid tissue (GALT) of patients with #postCOVIDsyndrome (PCS)/LC & the potential role of the gut-immune axis in the pathogenesis of LC.

Our Annual General Meeting took place yesterday. Thank you to everyone who joined us as we reflected on the past year and shared our core activities and achievements.

#LongCovid #LongCovidAwareness #LongCovidSupport #LongCovidRecovery #LongCovidCommunity #PostCovidSyndrome

Our online community, ME Connected, has over 1,400 members supporting each other and discussing topics ranging from tips and tricks on managing ME/CFS, to our popular book club!

Join today:  https://meassociation.org.uk/discord

#pwME #MECFS #LongCovid #PostCovidSyndrome #Discord #OnlineCommunity

News Medical: Study identifies antiviral protein IFN-γ as a potential biomarker for Long COVID fatigue - The ME Association A study, led by The University of Cambridge, has identified […]

News Medical: Study identifies antiviral protein IFN-γ as a potential biomarker for Long COVID fatigue 

Read more: https://meassociation.org.uk/vpow

#LongCovid #LongCovidResearch #PostCovidSyndrome

Widespread ncaas Imprints in the Serum Proteome of COVID-19 Convalescents Uncovering Immune System Sequelae — Kun Liu et al. "Consistently, the dysregulated and sustained [non-coded amino acids] in COVID-19 convalescents were functionally correlated with the pathways relevant to immune responses, complement activation, and coagulation, suggesting the biological impacts of the molecular imprints."

From China

Widespread ncaas Imprints in the Serum Proteome of COVID-19 Convalescents Uncovering Immune System Sequelae

www.mcponline.org/article/S153...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

NET Biomarkers in COVID-19 and Post-COVID Syndrome: a Comprehensive Analysis — Monsalve et al. "Our findings revealed a significant increase in NET biomarkers during acute COVID-19 that persisted in PCS. This pattern was consistent with the in vitro study, where sera from PCS patients induced NET release."

From Colombia

NET Biomarkers in COVID-19 and Post-COVID Syndrome: a Comprehensive Analysis

link.springer.com/article/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

Diminished EBV-Specific Humoral Immunity is Associated with Neuropsychiatric Long COVID Development up to 12 Months Post-COVID-19 Symptom Onset — Philip Samaan et al. "our study highlights that neuropsychiatric long COVID symptoms may not be attributable to alterations in SARS-CoV-2-specific cellular or humoral immunity. However, diminished EBV-specific humoral immunity emerged as a potential risk factor for neuropsychiatric long COVID development"

Diminished EBV-Specific Humoral Immunity is Associated with Neuropsychiatric Long COVID Development up to 12 Months
#PostCOVID19 Symptom Onset

www.biorxiv.org/content/10.6...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #LC #PostCovidSyndrome

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID — Samuel B. K. Keat et al. "We found that plasma concentrations of MASP-2/C1Inh were significantly increased in patients with long COVID relative to healthy convalescent individuals with no persistent symptoms after contemporaneous infection with SARS- CoV-2 (p = 0.0003)."

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID

onlinelibrary.wiley.com/doi/10.1111/...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

Video still with Dr Nancy Klimas Groundbreaking Long COVID Clinical Trial at NSU | Researchers Explore New Treatment Nova Southeastern University 4.49K subscribers Subscribe From an accredited US healthcare educator Learn how experts define health sources in a journal of the National Academy of Medicine 348 views Jan 28, 2026 #NSU #NSUFlorida #NovaSoutheasternUniversity Millions continue to struggle with the lasting effects of Long COVID years after the pandemic began. Researchers at Nova Southeastern University’s Institute for Neuro-Immune Medicine (INIM), led by Dr. Nancy Klimas, are conducting one of the few clinical trials focused on finding a cure for Long COVID. In this study, a monoclonal antibody treatment approved for COVID prevention is being tested as a possible treatment for the complex, chronic Long COVID condition. Over six months, researchers track patient responses, collect biological samples, and evaluate whether this treatment eases chronic symptoms and clears any lingering spike in protein from the initial infection. Funding for the study comes from the Florida Department of Health and the Schmidt Initiative for Long Covid (SILC). Long COVID patients can experience a range of debilitating symptoms that affect the brain, heart, and lungs, including fatigue and cognitive dysfunction, and one hundred patients are participating in this groundbreaking clinical trial to search for a cure. Learn more about Dr. Klimas’s groundbreaking work, the Long COVID clinical trial, and how NSU is shaping the future of neuroimmune medicine.

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Sympathetic 2-minute video piece on drug trial that is recruiting in Florida, USA

"Groundbreaking Long COVID Clinical Trial at NSU | Researchers Explore New Treatment"

www.youtube.com/watch?v=BcS1...

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

This trial in Florida (USA) led by sympathetic researcher Dr Nancy Klimas is now recruiting.

Here is an extract from the latest Institute for Neuro-Immune Medicine newsletter.

Link: redcap.nova.edu/redcap/surve...

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #PostCovidSyndrome

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IMAGE DESCRIPTION: Photo of the dark blue ME Association pin badge on a wooden background. Wording reads: Show your support with an ME Association pin badge. Only £3.80 with free shipping. MEA logo.

Show your support with an ME Association pin badge - only £3.80 with free shipping from our online shop: meassociation.org.uk/product/mea-round-pin-ba...

#MECFS #pwME #MyalgicEncephalomyelitis #MyalgicE #MyalgicEncephalopathy #MEAssociation #pwLongCovid #LongCovid #PostCovidSyndrome

The Sick Times "Severe people may hold answers to Long COVID. They must be included in research." This article argues that research studies which include severe cases "may reveal what drives the disease at its core, mechanisms that remain invisible in milder cases." It also lists examples of research studies that have included severe cases to demonstrate that it is possible.

The Sick Times @thesicktimes.org : "Severe people may hold answers to #LongCOVID. They must be included in research" by @neurologistmom.bsky.social

thesicktimes.org/2026/01/13/s...

Screenshot from Science for ME update

#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

Excess primary healthcare consultations in Norway in 2024 compared to pre-COVID-19-pandemic baseline trends — White et al. "Substantial increases were observed in primary healthcare consultations in 2024 compared to prepandemic levels. Many of the conditions with the greatest excess are associated with post-acute COVID-19 sequelae"

Excess primary healthcare consultations in Norway in 2024 compared to pre-COVID-19-pandemic baseline trends

link.springer.com/article/10.1...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome

Economic Burden of Long COVID: Lost Labor Costs in US Adults — Rachel Liu-Galvin et al. "In the study population, the weighted prevalence of LC was 7.8%" "The present results indicate the real-world cost of LC on lost labor far exceeds this, amounting to more than $12 billion in 2022 alone based on the population-level estimate."

Economic Burden of Long COVID: Lost Labor Costs in US Adults

www.jabfm.org/content/38/5...

"In the study population, the weighted prevalence of LC was 7.8%"

Screenshot from Science for ME weekly update

#novid #CovidIsNotOver #postcovid #postcovid19 #PostCovidSyndrome #COVIDBrain #NeuroPASC

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From: "Assessment of Post-Exertional Malaise (PEM) in Patients with ME and CFS: A Patient-Driven Survey" (2019) by a Leonard A. Jason team pmc.ncbi.nlm.nih.gov/articles/PMC...

#MyalgicE #PwME #MEeps #CFSME #CFIDS #PwLC
#PostCovidSyndrome #postcovid