Free-range chickens roaming across a grassy farm field.

#BirdFlu can already get inside human #cells. So why hasn’t it sparked a #pandemic? A recent study offers important clues. In PNAS Journal Club: https://ow.ly/pVPN50YvX4g

#AvianInfluenza #H5N1 #ZoonoticSpillover #RNAVirus #epidemic

Validate User

A bit less recent work published in @narjournal.bsky.social led by Klein, Das and Bera. Great collaboration with many labs showing that SARS-CoV-2 polymerase must undergo an activation step to enable RNA synthesis.
doi.org/10.1093/nar/...
#SARSCoV2 #polymerase #RNAvirus #singlemolecule

Our discovery of novel viruses in invasive camelids in Australia leads us to propose a simple idea: RNA viruses may repeatedly evolve functional modules at the 5′ end of their genomes.

#Virology #RNAvirus #VirusEvolution
#Picornavirus #VirusDiscovery

doi.org/10.64898/202...

#Medsky🧪 #IDsky #microsky #publichealth Groundbreaking research published has successfully retrieved near-complete #RNAvirus genomes from Adélie penguin mummies in Antarctica, some dating back nearly 2,000 years.

Study reveals over 3,500 uncharacterized RNA viral RdRp sequences in public protein databases, uncovering many novel endogenous viral elements and misclassified viruses.
#VirusEvolution #RNAvirus #Bioinformatics 🧬🧫
📄 https://doi.org/10.1093/ve/veaf074
👤 EVBC members: Andrew Firth, Katherine Brown

#bioinformatics #rnavirus #virology

From tracking SARS-CoV-2 in wastewater to discovering hidden marine RNA viruses, CLAE unlocks read-level viral variant detection and fixes short-read misassemblies.

⚡ Portable, field-ready
🧬 A game-changer for epidemiology & environmental surveillance.

#RNAvirus #metagenomics

Functional annotation of the selected protein QBQ56721.1. The graphical summary represents the conserved domains identified in the query sequence. The aligned sequences represent the conserved domains identified on the query sequence by comparing them with the conserved protein domain family matrix (CDD accession no. pfam00661). The Pfam software predicted a motif at 16–349 (accession no. PF00661) as a viral matrix protein. The SuperFamily program predicted the protein as a member of the matrix superfamily. An * (asterisk) indicates positions with a single, fully conserved residue.

New in silico study sheds light on the Nipah henipavirus matrix protein—an essential structural component linking the viral envelope to its core. With hydrophilic properties and an α-helix-rich structure, this protein plays a vital role in virus assembly.

👉 www.mdpi.com/2673-4583/12...

#RNAvirus

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic The widespread nature of several viruses is greatly credited to their rapidly altering RNA genomes that enable the infection to persist despite challe…

#MedSky🧪#IDSky #Drugdiscovery #Drugdevelopment Overview RNA-dependent RNA polymerase (#RdRp ) inhibitors: The current landscape & #drugrepurposing
that have been launched or are in clinical studies for the treatment of #RNAvirus infections, incl #COVID19.

www.sciencedirect.com/science/arti...